Nur77 modulator 4
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications .
For research use only. We do not sell to patients.
- Formula: C26H28ClN5O2
- Molecular Weight:477.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
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Nur77/NR4A1 0.477 μM (Kd) |
Chemical Information
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Molecular Weight 477.99
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Formula C26H28ClN5O2
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SMILES
O=C(NNC(NC1=CC=CC=C1Cl)=O)NC2=CC3=C(NC(C45CC6CC(C5)CC(C6)C4)=C3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nur77 modulator 4 Related Classifications
HY-170849 Related Classifications
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