ATF3 - activating transcription factor 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 467

About ATF3

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,565,407-212,620,777 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 8 paralogues. Ubiquitous expression in gall bladder (RPKM 38.3), liver (RPKM 37.5) and 23 other tissues.

Summary

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by Cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

ATF3 Products (6)

mRNA	Protein	Name
NM_001030287.4	NP_001025458.1	cyclic AMP-dependent transcription factor ATF-3 isoform 1
NM_001040619.3	NP_001035709.1	cyclic AMP-dependent transcription factor ATF-3 isoform 2
NM_001206484.3	NP_001193413.2	cyclic AMP-dependent transcription factor ATF-3 isoform 3
NM_001206486.2	NP_001193415.1	cyclic AMP-dependent transcription factor ATF-3 isoform 5
NM_001206488.3	NP_001193417.2	cyclic AMP-dependent transcription factor ATF-3 isoform 3
NM_001674.4	NP_001665.1	cyclic AMP-dependent transcription factor ATF-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16300731	GOA
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	24939851	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8622660	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2516827	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18255255	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10327051	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8622660	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8622660	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24939851	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7515060	GOA
involved in positive regulation of TRAIL-activated apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	24939851	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16300731	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8622660	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	24939851	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-ATF3 complex	IDA IDA: Inferred from direct assay	8622660	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7515060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF3 Protein Structure

bZIP_1

0
100
181 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-3	cAMP-dependent transcription factor ATF-3

ATF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATF3	P18847	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	ATF3	P18847	BATF3	Homo sapiens	Q9NR55	Y2H Array	20211142
Intra	ATF3	P18847	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	ATF3	P18847	ATF2	Homo sapiens	P15336	Y2H Array	20211142
Intra	ATF3	P18847	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ATF3	P18847	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ATF3	P18847	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ATF3	P18847	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	ATF3	P18847	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	ATF3	P18847	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	ATF3	P18847	JUND	Homo sapiens	P17535	Pull Down	30833792
Intra	ATF3	P18847	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	ATF3	P18847	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	ATF3	P18847	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	ATF3	P18847	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	ATF3	P18847	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ATF3	P18847	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ATF3	P18847	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ATF3	P18847	NFATC1	Homo sapiens	O95644	TAP	25609649
Intra	ATF3	P18847	FHL2	Homo sapiens	Q14192	Y2H	18255255
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	MAPPIT	31467278
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	BRET	37398436
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	BRET	29997244
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Y2H Array	20211142
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	SLC	31467278
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Complementation	31467278
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Lumier	29997244
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	BFG-2H	27107012
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Lumier	37398436
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Y2H Array	31467278
Intra	ATF3	P18847	DDIT3	Homo sapiens	P35638	Lumier	32814053
Intra	ATF3	P18847	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	ATF3	P18847	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	ATF3	P18847	CEBPG	Homo sapiens	P53567	Y2H Array	20211142
Intra	ATF3	P18847	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	ATF3	P18847	JUNB	Homo sapiens	P17275	Pull Down	30833792
Intra	ATF3	P18847	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	ATF3	P18847	ATF7	Homo sapiens	P17544	Pull Down	30833792
Intra	ATF3	P18847	JUN	Homo sapiens	P05412	FRET	23661758
Intra	ATF3	P18847	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	ATF3	P18847	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ATF3	P18847	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ATF3	P18847	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	ATF3	P18847	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	ATF3	P18847	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

ATF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84147	ATF3 Antibody (YA3844)	ICC/IF, FC, ELISA	Human
HY-P84147A	ATF3 Antibody (YA3844)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hypospadias	Hypospadias Familial Familial Hypospadias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Pelvic Organ Prolapse	Rectal Prolapse Pelvic Organ Prolapse, Susceptibility To, 1 Pelvic Organ Prolapse, Susceptibility To Prolapse Of Vagina And Rectum Vaginal Prolapse Pelvic Organ Prolapse 1 Procidentia, Rectum Prolapse Of Rectal Mucosa Procidentia Of Rectum Rectal Mucosa Prolapse Rectum Prolapse Procidentia Rectum Rp - [Rectal Prolapse] Male Proctocele Male Rectocele Proctoptosis Female Genital Prolapse Female Prolapse Incompetence Of Pelvic Fundus Relaxation Of Perineum Deficiency Of Perineum
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Plantar Fascial Fibromatosis	Dupuytren'S Contracture Of Foot Ledderhose'S Disease Fibromatosis, Plantar Ledderhose Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151923	ATF3 inducer 1	Inhibitor	99.61%	Unkown
HY-153347	JY-2		99.75%	Unkown
HY-W011927	4,4'-Sulfonyldiphenol		99.81%	Unkown
HY-12756	E6446		98.78%	Unkown
HY-12756A	E6446 dihydrochloride		99.29%	Unkown
HY-175032	ATF3-IN-1		96.30%	Unkown
HY-N0660	Jujuboside B		99.92%	Unkown
HY-W011927S	4,4'-Sulfonyldiphenol-d8		99.21%	Unkown
HY-RS01129	ATF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162384	EPIC-0628	Inhibitor	98.66%	Unkown
HY-163319	NCA029		98.24%	Unkown
HY-178154	FB231		99.45%	Unkown
HY-155158	Anticancer agent 147	Inducer	/	Unkown
HY-181982	HJ03		/	Unkown
HY-N0660R	Jujuboside B (Standard)		/	Unkown
HY-RS16909	Atf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23351	Atf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATF3	MGD	MGI:109384
Bos taurus	ATF3	VGNC	VGNC:26241
Macaca mulatta	ATF3	VGNC	VGNC:70170
Rattus norvegicus	ATF3	RGD	RGD:2165
Felis catus	ATF3	VGNC	VGNC:68503
Canis familiaris	ATF3	VGNC	VGNC:38209
Others	ATF3	NCBI