2. Apoptosis Epigenetics Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Epigenetic Reader Domain Reactive Oxygen Species (ROS) Glutathione Peroxidase
  4. ATF3-IN-1

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke.

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ATF3-IN-1

ATF3-IN-1 Chemical Structure

CAS No. : 2952703-90-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

ATF3-IN-1 Related Antibodies

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GPX1 GPX4

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Description

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].

IC50 & Target

GPX4

 

In Vitro

ATF3-IN-1 (Compound 1c) (0.1-2 μM) eases I/R injury by inhibiting oxidative stress and ferroptosis in primary cortical neurons oxygen-glucose deprivation (OGD) models[1].

ATF3-IN-1 (0.1-2 μM) has no cytotoxicity in rat cortical neurons without OGD[1].

ATF3-IN-1 attenuates ferroptosis and reduces I/R injury through the ATF3/SLC7A11/GPX4 axis in primary cortical neurons OGD models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATF3-IN-1 Related Antibodies
In Vivo

ATF3-IN-1 (Compound 1c) (2 mg/kg, ICV, single dose) reduces infarct volume and promotes neurological recovery after cerebral I/R injury by regulating the ATF3/SLC7A11/GPX4 axis, oxidative stress, and ferroptosis in the rat middle cerebral artery occlusion (MCAO) model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (250 g, Six-week-old) MCAO model[1]
Dosage: 2 mg/kg
Administration: ICV, once
Result: Inhibited ATF3 expression and reduces ROS production, Upregulated SLC7A11 and GPX4 expression.
Molecular Weight

451.55

Formula

C24H37NO7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (221.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2146 mL 11.0730 mL 22.1459 mL
5 mM 0.4429 mL 2.2146 mL 4.4292 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2146 mL 11.0730 mL 22.1459 mL 55.3649 mL
5 mM 0.4429 mL 2.2146 mL 4.4292 mL 11.0730 mL
10 mM 0.2215 mL 1.1073 mL 2.2146 mL 5.5365 mL
15 mM 0.1476 mL 0.7382 mL 1.4764 mL 3.6910 mL
20 mM 0.1107 mL 0.5536 mL 1.1073 mL 2.7682 mL
25 mM 0.0886 mL 0.4429 mL 0.8858 mL 2.2146 mL
30 mM 0.0738 mL 0.3691 mL 0.7382 mL 1.8455 mL
40 mM 0.0554 mL 0.2768 mL 0.5536 mL 1.3841 mL
50 mM 0.0443 mL 0.2215 mL 0.4429 mL 1.1073 mL
60 mM 0.0369 mL 0.1845 mL 0.3691 mL 0.9227 mL
80 mM 0.0277 mL 0.1384 mL 0.2768 mL 0.6921 mL
100 mM 0.0221 mL 0.1107 mL 0.2215 mL 0.5536 mL
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ATF3-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATF3-IN-12952703-90-9FerroptosisEpigenetic Reader DomainReactive Oxygen Species (ROS)Glutathione PeroxidaseInhibitorIschemic strokeOGD modelsMCAO modelinhibitorinhibit

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