ATF3-IN-1
Based on 1 Customer Validation
ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.30%
- CAS 番号: 2952703-90-9
- 分子式: C24H37NO7
- 分子量:451.55
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GPX4 |
ATF3-IN-1 (Compound 1c) (0.1-2 μM) eases I/R injury by inhibiting oxidative stress and ferroptosis in primary cortical neurons oxygen-glucose deprivation (OGD) models[1].
ATF3-IN-1 (0.1-2 μM) has no cytotoxicity in rat cortical neurons without OGD[1].
ATF3-IN-1 attenuates ferroptosis and reduces I/R injury through the ATF3/SLC7A11/GPX4 axis in primary cortical neurons OGD models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat (250 g, Six-week-old) MCAO model[1]
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Dosage:2 mg/kg
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Administration:ICV, once
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Result:Inhibited ATF3 expression and reduces ROS production, Upregulated SLC7A11 and GPX4 expression.
化学情報
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CAS 番号 2952703-90-9
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性状 Solid
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分子量 451.55
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分子式 C24H37NO7
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Color Light yellow to yellow
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SMILES
O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (221.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2146 mL | 11.0730 mL | 22.1459 mL | 55.3649 mL |
| 5 mM | 0.4429 mL | 2.2146 mL | 4.4292 mL | 11.0730 mL | |
| 10 mM | 0.2215 mL | 1.1073 mL | 2.2146 mL | 5.5365 mL | |
| 15 mM | 0.1476 mL | 0.7382 mL | 1.4764 mL | 3.6910 mL | |
| 20 mM | 0.1107 mL | 0.5536 mL | 1.1073 mL | 2.7682 mL | |
| 25 mM | 0.0886 mL | 0.4429 mL | 0.8858 mL | 2.2146 mL | |
| 30 mM | 0.0738 mL | 0.3691 mL | 0.7382 mL | 1.8455 mL | |
| 40 mM | 0.0554 mL | 0.2768 mL | 0.5536 mL | 1.3841 mL | |
| 50 mM | 0.0443 mL | 0.2215 mL | 0.4429 mL | 1.1073 mL | |
| 60 mM | 0.0369 mL | 0.1845 mL | 0.3691 mL | 0.9227 mL | |
| 80 mM | 0.0277 mL | 0.1384 mL | 0.2768 mL | 0.6921 mL | |
| 100 mM | 0.0221 mL | 0.1107 mL | 0.2215 mL | 0.5536 mL |
ATF3-IN-1 関連分類
HY-175032 関連分類
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