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BATF3 - basic leucine zipper ATF-like transcription factor 3 Gene

Also Known as JDP1; SNFT; JUNDM1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55509

About BATF3

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,686,417-212,699,840 (from NCBI)

This gene has 3 transcripts (splice variants), 173 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.9), appendix (RPKM 1.9) and 20 other tissues.

Summary

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

BATF3 Products (1)

mRNA	Protein	Name
NM_018664.3	NP_061134.1	basic leucine zipper transcriptional factor ATF-like 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15467742	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15467742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15467742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF3 Protein Structure

bZIP_1

0
100
127 a.a.

Protein Preferred Names	Protein Names
basic leucine zipper transcriptional factor ATF-like 3	21 kDa small nuclear factor isolated from T-cells

BATF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BATF3	Q9NR55	DDIT3	Homo sapiens	P35638-2	Y2H Array	25416956
Intra	BATF3	Q9NR55	CREB5	Homo sapiens	Q02930-3	Y2H Prey Pooling	32296183
Intra	BATF3	Q9NR55	CREB5	Homo sapiens	Q02930-3	Y2H Array	32296183
Intra	BATF3	Q9NR55	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	BATF3	Q9NR55	ATF2	Homo sapiens	P15336	Anti Tag CoIP	28514442
Intra	BATF3	Q9NR55	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	BATF3	Q9NR55	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	BATF3	Q9NR55	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	BATF3	Q9NR55	BACH2	Homo sapiens	Q9BYV9	FRET	23661758
Intra	BATF3	Q9NR55	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	33961781
Intra	BATF3	Q9NR55	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	BATF3	Q9NR55	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	28514442
Intra	BATF3	Q9NR55	JUND	Homo sapiens	P17535	Anti Tag CoIP	33961781
Intra	BATF3	Q9NR55	JUND	Homo sapiens	P17535	Anti Tag CoIP	28514442
Intra	BATF3	Q9NR55	JUND	Homo sapiens	P17535	Peptide Array	20102225
Intra	BATF3	Q9NR55	DBP	Homo sapiens	Q10586	FRET	23661758
Intra	BATF3	Q9NR55	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	BATF3	Q9NR55	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	BATF3	Q9NR55	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	BATF3	Q9NR55	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	BATF3	Q9NR55	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	BATF3	Q9NR55	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	BATF3	Q9NR55	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	BATF3	Q9NR55	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	BATF3	Q9NR55	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
Intra	BATF3	Q9NR55	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	BATF3	Q9NR55	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
Intra	BATF3	Q9NR55	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	BATF3	Q9NR55	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	BATF3	Q9NR55	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	BATF3	Q9NR55	JUNB	Homo sapiens	P17275	Anti Tag CoIP	28514442
Intra	BATF3	Q9NR55	JUNB	Homo sapiens	P17275	Peptide Array	20102225
Intra	BATF3	Q9NR55	JUN	Homo sapiens	P05412	Peptide Array	20102225
Intra	BATF3	Q9NR55	JUN	Homo sapiens	P05412	FRET	23661758
Intra	BATF3	Q9NR55	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	BATF3	Q9NR55	JUN	Homo sapiens	P05412	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dendritic Cell Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01373	BATF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21496	Batf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28014	Batf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BATF3	VGNC	VGNC:38387
Bos taurus	BATF3	VGNC	VGNC:26427
Mus musculus	BATF3	MGD	MGI:1925491
Felis catus	BATF3	VGNC	VGNC:107843
Macaca mulatta	BATF3	VGNC	VGNC:70143
Rattus norvegicus	BATF3	RGD	RGD:620501
Others	BATF3	NCBI