BACH2 - BTB domain and CNC homolog 2 Gene

Also Known as IMD60; BTBD25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60468

About BACH2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,926,528-90,296,843 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues, 54 paralogues and is associated with 1 phenotype. Biased expression in lymph node (RPKM 7.1), appendix (RPKM 2.5) and 10 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Implicated in immunodeficiency 60. [provided by Alliance of Genome Resources, Apr 2022]

BACH2 Products (2)

mRNA Protein Name
NM_001170794.2 NP_001164265.1 transcription regulator protein BACH2
NM_021813.4 NP_068585.1 transcription regulator protein BACH2

BACH2 Protein Structure

BTB

BTB: BTB/POZ domain (27 - 132)

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (618 - 695)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 841 a.a.
Protein Preferred Names Protein Names

transcription regulator protein BACH2

  • BTB and CNC homolog 2

BACH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BACH2 Q9BYV9 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 BATF3 Homo sapiens Q9NR55
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 TSHZ2 Homo sapiens Q9NRE2
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 MAFK Homo sapiens O60675
Anti Tag CoIP
33961781
Intra
BACH2 Q9BYV9 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 MAFG Homo sapiens O15525
FRET
23661758
Intra
BACH2 Q9BYV9 MAFG Homo sapiens O15525
Anti Tag CoIP
33961781
Intra
BACH2 Q9BYV9 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra
BACH2 Q9BYV9 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 CTSZ Homo sapiens Q9UBR2
Validated Y2H
32296183
Intra
BACH2 Q9BYV9 MLX Homo sapiens Q9UH92-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 60 And Autoimmunity

  • Immunodeficiency And Autoimmunity, Bach2-Related

  • IMD60

  • Brida

  • Immunodeficiency 60
Immunodeficiency 60

  • Bach2-Related Immunodeficiency And Autoimmunity

  • Brida

  • Imd60
Immunodeficiency 58

  • IMD58

  • Severe Combined Immunodeficiency Due To Carmil2 Deficiency

  • Combined Immunodeficiency Due To Carmil2 Deficiency

  • Combined Immunodeficiency Due To Rltpr Deficiency
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19986 Bach2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01340 BACH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26490 Bach2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BACH2 MGD MGI:894679
Bos taurus BACH2 VGNC VGNC:26403
Macaca mulatta BACH2 VGNC VGNC:70069
Canis familiaris BACH2 VGNC VGNC:38361
Rattus norvegicus BACH2 RGD RGD:1562865
Felis catus BACH2 VGNC VGNC:60068
Others BACH2 NCBI