MAFG - MAF bZIP transcription factor G Gene

Homo sapiens

Also known as hMAF

Gene ID: 4097 | Gene type: protein coding

About MAFG

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,918,270-81,931,244 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues.

Summary

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

MAFG Products(2)

mRNA	Protein	Name
NM_002359.4	NP_002350.1	transcription factor MafG
NM_032711.4	NP_116100.2	transcription factor MafG

MAFG Protein Structure

bZIP_Maf

0
100
162 a.a.

Protein Preferred Names

Protein Names

transcription factor MafG

basic leucine zipper transcription factor MafG

Related Diseases

Diseases

Alias

Homocystinuria-Megaloblastic Anemia Cble Type

Functional Methionine Synthase Deficiency Type Cble	Hmae
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cble Complementation Type	Methylcobalamin Deficiency, Cble Type
Vitamin B12-Responsive Homocystinuria, Cble Type

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Clear Cell Acanthoma

Acanthoma	Pale Acanthoma
Acanthoma, Clear Cell

Ayme-Gripp Syndrome

AYGRP	Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation
Aymé-Gripp Syndrome	Fine-Lubinsky Syndrome
Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome	Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07961	MAFG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAFG	VGNC	VGNC:42921
Bos taurus	MAFG	VGNC	VGNC:31141
Felis catus	MAFG	VGNC	VGNC:99208
Mus musculus	MAFG	MGD	MGI:96911
Rattus norvegicus	MAFG	RGD	RGD:619953
Macaca mulatta	MAFG	VGNC	VGNC:74474
Macaca fascicularis	MAFG	NCBI
Others	MAFG	NCBI