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BACH1 - BTB domain and CNC homolog 1 Gene

Also Known as BACH-1; BTBD24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 571

About BACH1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,298,922-29,361,894 (from NCBI)

This gene has 13 transcripts (splice variants), 257 orthologues and 54 paralogues. Ubiquitous expression in bone marrow (RPKM 19.7), placenta (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

BACH1 Products (2)

mRNA	Protein	Name
NM_001186.4	NP_001177.1	transcription regulator protein BACH1
NM_206866.3	NP_996749.1	transcription regulator protein BACH1

BACH1 Protein Structure

BTB

bZIP_Maf

0
200
400
600
736 a.a.

Protein Preferred Names	Protein Names
transcription regulator protein BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1

BACH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BACH1	O14867	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	BACH1	O14867	VHL	Homo sapiens	P40337-2	Y2H Pooling	32814053
Intra	BACH1	O14867	VHL	Homo sapiens	P40337-2	Validated Y2H	32814053
Intra	BACH1	O14867	VHL	Homo sapiens	P40337-2	Y2H Array	32814053
Intra	BACH1	O14867	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	BACH1	O14867	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	BACH1	O14867	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	BACH1	O14867	DYNLL1	Homo sapiens	P63167	Y2H Fragment Pooling	35914814
Intra	BACH1	O14867	MAFB	Homo sapiens	Q9Y5Q3	Peptide Array	20102225
Intra	BACH1	O14867	MAFB	Homo sapiens	Q9Y5Q3	Anti Tag CoIP	33961781
Intra	BACH1	O14867	MAFG	Homo sapiens	O15525	Peptide Array	20102225
Intra	BACH1	O14867	MAFG	Homo sapiens	O15525	Anti Tag CoIP	33961781
Intra	BACH1	O14867	MAFG	Homo sapiens	O15525	Anti Tag CoIP	26496610
Intra	BACH1	O14867	MAFG	Homo sapiens	O15525	Anti Tag CoIP	28514442
Intra	BACH1	O14867	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	BACH1	O14867	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	BACH1	O14867	MAFF	Homo sapiens	Q9ULX9	Anti Tag CoIP	26496610
Intra	BACH1	O14867	MAFF	Homo sapiens	Q9ULX9	Anti Tag CoIP	33961781
Intra	BACH1	O14867	MAFF	Homo sapiens	Q9ULX9	Anti Tag CoIP	28514442
Intra	BACH1	O14867	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-167874	ASP-8731	Inhibitor	98.42%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153040	HPPE	Inhibitor	99.71%	Unkown
HY-111827	S-1-Propenyl-L-cysteine		99.91%	Unkown
HY-RS01339	BACH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-17655	TBE56	Inhibitor	/	Unkown
HY-RS01623	BRIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17026	Bach1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20866	Brip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23469	Bach1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BACH1	MGD	MGI:894680
Felis catus	BACH1	VGNC	VGNC:69035
Macaca mulatta	BACH1	VGNC	VGNC:70217
Rattus norvegicus	BACH1	RGD	RGD:1306693
Bos taurus	BACH1	VGNC	VGNC:26402
Canis familiaris	BACH1	VGNC	VGNC:38360
Others	BACH1	NCBI