MAFB - MAF bZIP transcription factor B Gene

Homo sapiens

Also known as KRML; MCTO; DURS3

Gene ID: 9935 | Gene type: protein coding

About MAFB

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:40,685,848-40,689,236 (from NCBI)

This gene has 1 transcript (splice variant), 245 orthologues, 6 paralogues and is associated with 52 phenotypes.

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]

MAFB Products(1)

mRNA	Protein	Name
NM_005461.5	NP_005452.2	transcription factor MafB

MAFB Protein Structure

Maf_N

bZIP_Maf

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

transcription factor MafB

Kreisler maf-related leucine zipper homolog

Related Diseases

Diseases

Alias

Multicentric Carpotarsal Osteolysis Syndrome

Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy	MCTO
Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy	Idiopathic Multicentric Osteolysis With Or Without Nephropathy
Autosomal Dominant Multicentric Osteolysis	Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy
Multicentric Osteolysis, Autosomal Dominant	Multicentric Osteolysis Nephropathy
Osteolysis, Carpotarsal, Multicentric Syndrome	Lytic Lesion

Duane Retraction Syndrome 3 With Or Without Deafness

DURS3	Duane Retraction Syndrome 3
Duane Retraction Syndrome With Congenital Deafness	Drs With Deafness
Drs With Hearing Loss	Durs With Deafness
Durs With Hearing Loss	Duane Retraction Syndrome With Congenital Hearing Loss

Duane Retraction Syndrome 2

DURS2

Duane Retraction Syndrome, Type 2

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Amblyopia

Lazy Eye

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance	Mgus
Mgus - [Monoclonal Gammopathy Of Undetermined Significance]	Monoclonal Gammopathy Nos
Iga Gammopathy	Monoclonal Gammoglobulinopathy

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Smoldering Myeloma

Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Plasma Cell Leukemia

Plasma Cell Leukaemia	Leukemia, Plasma Cell
Plasmacytic Leukaemia	Plasmacytic Leukemia
Pcl	Plasma Cell Leukaemia, Nos
Leukemic Plasma Cell	Plasma Cell Leukaemia Without Mention Of Remission

Theileriasis

Theileriosis

Infection By Theileria

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Orofacial Cleft

Cleft, Orofacial

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07959	MAFB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAFB	VGNC	VGNC:67982
Canis familiaris	MAFB	VGNC	VGNC:54653
Macaca mulatta	MAFB	VGNC	VGNC:74419
Bos taurus	MAFB	VGNC	VGNC:31139
Rattus norvegicus	MAFB	RGD	RGD:2982
Mus musculus	MAFB	MGD	MGI:104555