IRF3 - interferon regulatory factor 3 Gene

Also Known as IIAE7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3661

About IRF3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,659,572-49,665,857 (from NCBI)

This gene has 31 transcripts (splice variants), 200 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 23.8), lymph node (RPKM 21.2) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as Other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]

IRF3 Products (8)

mRNA	Protein	Name
NM_001197122.2	NP_001184051.1	interferon regulatory factor 3 isoform 2
NM_001197123.2	NP_001184052.1	interferon regulatory factor 3 isoform 3
NM_001197124.2	NP_001184053.1	interferon regulatory factor 3 isoform 4
NM_001197125.2	NP_001184054.1	interferon regulatory factor 3 isoform 5
NM_001197126.2	NP_001184055.1	interferon regulatory factor 3 isoform 5
NM_001197127.2	NP_001184056.1	interferon regulatory factor 3 isoform 6
NM_001197128.2	NP_001184057.1	interferon regulatory factor 3 isoform 6
NM_001571.6	NP_001562.1	interferon regulatory factor 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	8524823	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17560375	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8524823	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8524823	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8524823	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	17560375	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15841462	GOA
enables protein binding	IDA IDA: Inferred from direct assay	10920266	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15841462	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11583620	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22394562	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12062447	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17574024	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in TRIF-dependent toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	25636800	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	9891032	GOA
involved in cellular response to virus	IDA IDA: Inferred from direct assay	25609812	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	8524823	GOA
involved in mRNA transcription	IDA IDA: Inferred from direct assay	9891032	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8524823	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17560375	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	18636090	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	25609812	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	25636800	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	8524823	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	9566918	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17079289	GOA
located in cytoplasm	IGI IGI: Inferred from genetic interaction	23729669	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25609812	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	10805757	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17079289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF3 Protein Structure

IRF

IRF-3

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 3

IRF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRF3	Q14653	RIOK3	Homo sapiens	O14730	Anti Bait CoIP	24807708
Intra	IRF3	Q14653	IRF1	Homo sapiens	P10914	Anti Tag CoIP	32878885
Cross	IRF3	Q14653	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Anti Tag CoIP	17761676
Cross	IRF3	Q14653	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	CoIP	17761676
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	GMS	23746807
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	20581830
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comigration in Gel	21102435
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	BN-PAGE	19454348
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	Ion Exchange Chrom	16154084
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Anti Bait CoIP	32726803
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	X-Ray Diffraction	16154084
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	34084167
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	16154084
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	Pull Down	16154084
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Solution Sedimentation	23746807
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	20403326
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	19416887
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	18725644
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	BN-PAGE	15841462
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	TAP	25609649
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	22000020
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	20581830
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	BN-PAGE	16301520
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	21782231
Intra	IRF3	Q14653	IRF3	Homo sapiens	Q14653	Comig Non-Denat Gel	22728658
Intra	IRF3	Q14653	SGTA	Homo sapiens	O43765	Y2H	21988832
Intra	IRF3	Q14653	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	34950606
Intra	IRF3	Q14653	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	24807708
Intra	IRF3	Q14653	TBK1	Homo sapiens	Q9UHD2	Protein Kinase Assay	18583960
Intra	IRF3	Q14653	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	IRF3	Q14653	KPNA6	Homo sapiens	O60684	Anti Bait CoIP	34950606
Intra	IRF3	Q14653	KPNA6	Homo sapiens	O60684	Anti Tag CoIP	34950606
Intra	IRF3	Q14653	MAFB	Homo sapiens	Q9Y5Q3	IF	20581830
Intra	IRF3	Q14653	MAFB	Homo sapiens	Q9Y5Q3	Anti Tag CoIP	20581830
Intra	IRF3	Q14653	RB1	Homo sapiens	P06400	Anti Tag CoIP	21903422
Intra	IRF3	Q14653	GRIP1	Homo sapiens	Q9Y3R0	Y2H	16362036
Intra	IRF3	Q14653	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	32878885
Intra	IRF3	Q14653	ISG15	Homo sapiens	P05161	Anti Bait CoIP	32726803
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	Anti Tag CoIP	21903422
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	CoIP	17761676
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	GMS	23746807
Intra	IRF3	Q14653	CREBBP	Homo sapiens	Q92793	Solution Sedimentation	16154084
Intra	IRF3	Q14653	RBL1	Homo sapiens	P28749	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80504	IRF3 Antibody (YA334)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P81022A	Phospho-IRF3 (Ser386) Antibody (YA7192)	WB, ICC/IF	Human
HY-P81022AA	Phospho-IRF3 (Ser386) Antibody (YA7192)(PBS only)	WB, ICC/IF	Human
HY-P84572	IRF3 Antibody (YA4269)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84572A	IRF3 Antibody (YA4269)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P85698	IRF3 Antibody (YA5390)	IHC-P, WB	Human, Mouse, Rat
HY-P86486	IRF3 Antibody (YA6178)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Encephalopathy, Acute, Infection-Induced 7	IIAE7 Herpes Simplex Encephalitis, Susceptibility To, 5 Encephalopathy, Acute, Infection-Induced , Susceptibility To, 7 Herpes Simplex Encephalitis 5 Encephalopathy, Acute, Infection-Induced, 7, Herpes-Specific Encephalopathy, Acute, Infection-Induced, 7 Herpes Simplex Encephalitis 7 Hse7 Infection-Induced Acute Encephalopathy 7 Encephalitis, Herpes Simplex, Susceptibility To, Type 5
Encephalopathy, Acute, Infection-Induced 10	Herpes Simplex Encephalitis, Susceptibility To, 7 IIAE10 Encephalopathy, Acute, Infection-Induced , Susceptibility To, 10 Herpes Simplex Encephalitis 7 Encephalitis, Herpes Simplex, Susceptibility To, Type 7
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Vaccinia
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Rabies	Lyssa Hydrophobia St Hubert Disease
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Mouth Disease	Mouth Diseases Mouth Disorders
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Bronchiolitis
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Oropouche Fever	Oropouche Virus Disease Oropouche Mosquito-Borne Viral Fever
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Phlebotomus Fever	Pappataci Fever Sandfly Fever Sandfly-Borne Phleboviral Disease Sandfly-Borne Arboviral Fever Sandfly-Borne Bunyavirus Fever Three Day Fever Chitral Fever Italy Summer Grippe Italy Summer Grippe Influenza
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Argentine Hemorrhagic Fever	Argentinian Hemorrhagic Fever Junin Hemorrhagic Fever Hemorrhagic Fever, Argentinian Ahf - [Argentinian Haemorrhagic Fever] Argentine Haemorrhagic Fever Junin Haemorrhagic Fever
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Monkeypox	Monkeypox Virus Infections
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Herpes Simplex Virus Keratitis	Dendritic Keratitis Keratitis, Dendritic Keratitis, Herpetic
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
West Nile Fever
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Listeriosis	Listeria Infection Infection By Listeria Monocytogenes Listeria Monocytogenes Infection Listeria Infections Listerial Foodborne Infection Circling Disease Infection Due To Listeria Monocytogenes Listerellosis
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Coronavirus Infectious Disease
Poliomyelitis	Polio Infantile Paralysis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-176426	Subquinocin		99.83%	Phase 4
HY-10249	GSK-690693		99.03%	Phase 1

Pre-clinical Phase

Bioactive Molecules (71)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12326A	c-di-AMP disodium	Agonist	99.14%	Unkown
HY-160225	ISD sodium		98.02%	Unkown
HY-113469	Cyclic GMP		99.77%	Unkown
HY-P1680	Astin C	Inhibitor	99.47%	Unkown
HY-P1934	Cyclo(Phe-Pro)	Inhibitor	99.22%	Unkown
HY-101950	KIN1148	Inhibitor	98.0%	Unkown
HY-P11072	IRF5-CPP5	Inhibitor	99.23%	Unkown
HY-113469A	Cyclic GMP sodium		99.89%	Unkown
HY-139056	SU0268	Inhibitor	99.96%	Unkown
HY-12326B	c-di-AMP diammonium	Agonist	99.01%	Unkown
HY-152956	STING agonist-23	Agonist	99.33%	Unkown
HY-W140974	SN-001	Inhibitor	99.22%	Unkown
HY-156449	STING-IN-7	Inhibitor	98.29%	Unkown
HY-112951	ChX710		99.91%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-D0162	Malachite green hemioxalate		98.0%	Unkown
HY-124652	TBK1/IKKε-IN-4	Inhibitor	99.42%	Unkown
HY-173425	STING-IN-15	Inhibitor	99.04%	Unkown
HY-17663	KMR-206		98.86%	Unkown
HY-164278	diABZI-V/C-Mal		99.28%	Unkown
HY-12326	c-di-AMP	Agonist	99.29%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-126113	KIN101		99.44%	Unkown
HY-168034	diABZI-4		98.33%	Unkown
HY-177338	STING agonist-45	Agonist	99.10%	Unkown
HY-181526	Sim-9	Inhibitor	/	Unkown
HY-113469B	Cyclic GMP TBAOH		/	Unkown
HY-W654000	Cyclic GMP-13C,15N2		98.81%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium		/	Unkown
HY-160222	HSV-60mer sodium		98.11%	Unkown
HY-160225F	Biotin-labeled ISD sodium		/	Unkown
HY-162133	MSA-2-Pt		/	Unkown
HY-173462	TBK1-IN-2	Inhibitor	98.19%	Unkown
HY-175714	STING agonist-46	Agonist	98.63%	Unkown
HY-176192	SMU-14a	Inhibitor	/	Unkown
HY-178049	UM-259	Inhibitor	/	Unkown
HY-W767865	Cyclic GMP sodium-13C5		99.03%	Unkown
HY-148606	STING modulator-3	Inhibitor	/	Unkown
HY-148645	STING modulator-4	Modulator	/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-158036	PROTAC STING Degrader-2		/	Unkown
HY-162844	CDN-3	Activator	/	Unkown
HY-162963	DN203316		/	Unkown
HY-162966	MS7829	Activator	/	Unkown
HY-162967	MS8588	Degrader	/	Unkown
HY-173399	hSTING activator-1		/	Unkown
HY-174136	STING Degrader-2		/	Unkown
HY-174308	ZSA-215	Agonist	/	Unkown
HY-178047	UM-242	Inhibitor	/	Unkown
HY-178690	MyD88-IN-4	Inhibitor	/	Unkown
HY-178915	ITA-5	Inhibitor	/	Unkown
HY-178916	ITA-9	Inhibitor	/	Unkown
HY-178951	STING-IN-17	Inhibitor	/	Unkown
HY-180120	UM-203		/	Unkown
HY-180674	LA24	Agonist	/	Unkown
HY-181484	STING agonist-50		/	Unkown
HY-182923	UM-200	Inhibitor	/	Unkown
HY-183537	KSI-028	Inhibitor	/	Unkown
HY-183607	SMU-3k		/	Unkown
HY-184200	Enpp-1-IN-32		/	Unkown
HY-N18197	Norkurarinol		/	Unkown
HY-RS06907	IRF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149724	Anti-inflammatory agent 65	Inhibitor	/	Unkown
HY-N10175	Berkeleyacetal C		/	Unkown
HY-N3548	Catalpalactone	Inhibitor	/	Unkown
HY-N8107	Matairesinol monoglucoside		99.42%	Unkown
HY-RS16587	Irf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23022	Irf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W682115	Poly(C)	Activator	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991989	MRG004A Antibody		95.44%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IRF3	VGNC	VGNC:67824
Canis familiaris	IRF3	VGNC	VGNC:54848
Macaca mulatta	IRF3	VGNC	VGNC:73761
Bos taurus	IRF3	VGNC	VGNC:30274
Rattus norvegicus	IRF3	RGD	RGD:1549774
Mus musculus	IRF3	MGD	MGI:1859179
Others	IRF3	NCBI