diABZI-V/C-Mal
Based on 1 Customer Validation
diABZI-V/C-Mal is a STING agonist (with a STING EC50 of 314 nM in TH1 dual reporter cells) and a Cathepsin B substrate. diABZI-V/C-Mal activates STING, thereby triggering the IRF3 signaling pathway. diABZI-V/C-Mal is cleaved by Cathepsin B to regenerate diABZI-NH2.
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- Reinheit: 99.28%
- CAS. Nr.: 3035557-55-9
- Formel: C67H83N19O14
- Molecular Weight:1378.49
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cathepsin B |
diABZI-V/C-Mal (50 μM; 48 h) undergoes cleavage by activated cathepsin B in a cell-free system, as evidenced by a shift in molecular weight matching the liberated diABZI-NH2 fragment[1].
diABZI-V/C-Ma activates STING-mediated IRF3 signaling in THP-1 dual reporter cells with potency comparable to diABZI-NH2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3035557-55-9
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Appearance Solid
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Molecular Weight 1378.49
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Formel C67H83N19O14
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Color White to off-white
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SMILES
O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OC)=C3N2C/C=C/CN4C5=C(OCCCNC(OCC6=CC=C(C=C6)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)=O)C=C(C(N)=O)C=C5N=C4NC(C8=CC(C)=NN8CC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (72.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7254 mL | 3.6272 mL | 7.2543 mL | 18.1358 mL |
| 5 mM | 0.1451 mL | 0.7254 mL | 1.4509 mL | 3.6272 mL | |
| 10 mM | 0.0725 mL | 0.3627 mL | 0.7254 mL | 1.8136 mL | |
| 15 mM | 0.0484 mL | 0.2418 mL | 0.4836 mL | 1.2091 mL | |
| 20 mM | 0.0363 mL | 0.1814 mL | 0.3627 mL | 0.9068 mL | |
| 25 mM | 0.0290 mL | 0.1451 mL | 0.2902 mL | 0.7254 mL | |
| 30 mM | 0.0242 mL | 0.1209 mL | 0.2418 mL | 0.6045 mL | |
| 40 mM | 0.0181 mL | 0.0907 mL | 0.1814 mL | 0.4534 mL | |
| 50 mM | 0.0145 mL | 0.0725 mL | 0.1451 mL | 0.3627 mL | |
| 60 mM | 0.0121 mL | 0.0605 mL | 0.1209 mL | 0.3023 mL |
diABZI-V/C-Mal Related Classifications
HY-164278 Related Classifications
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