2. PROTAC Immunology/Inflammation
  3. PROTACs Cyclic GMP-AMP Synthase STING
  4. MS8588

MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity.

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MS8588

MS8588 Chemical Structure

CAS No. : 3060519-94-7

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Description

MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity[1].

In Vitro

MS8588 (0-10 μM; 0-24 h) stabilizes cGAS and activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in a concentration-, time-, cGAS- and OTUB1-dependent manner, without altering the expression level of cGAS mRNA; its stabilizing effect on cGAS reaches a peak when acting at 5 μM for 24 h[1].
MS8588 (5 μM; 2-14 days) effectively inhibits the proliferation and colony-forming ability of HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS8588 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa cells
Concentration: 5 μM
Incubation Time: 2 days (proliferation assay); 2 weeks (clonogenicity assay)
Result: Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.
Molecular Weight

924.98

Formula

C45H59Cl2N9O6S
CAS No.
SMILES

ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CCNC(CCCCCCCCCC(NCCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS8588 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS85883060519-94-7MS 8588MS-8588PROTACsCyclic GMP-AMP SynthaseSTINGcGASStimulator of Interferon GenesTMEM173MITAERISMPYSOTUB1 deubiquitinaseHeLa cellsinnate immune signaling pathwayIRF3HT-DNAInhibitorinhibitorinhibit

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