MS8588
MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3060519-94-7
- Formula: C45H59Cl2N9O6S
- Molecular Weight:924.98
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MS8588 (0-10 μM; 0-24 h) stabilizes cGAS and activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in a concentration-, time-, cGAS- and OTUB1-dependent manner, without altering the expression level of cGAS mRNA; its stabilizing effect on cGAS reaches a peak when acting at 5 μM for 24 h[1].
MS8588 (5 μM; 2-14 days) effectively inhibits the proliferation and colony-forming ability of HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa cells
-
Concentration:5 μM
-
Incubation Time:2 days (proliferation assay); 2 weeks (clonogenicity assay)
-
Result:Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.
Chemical Information
-
CAS No. 3060519-94-7
-
Molecular Weight 924.98
-
Formula C45H59Cl2N9O6S
-
SMILES
ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CCNC(CCCCCCCCCC(NCCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz