1. Immunology/Inflammation
    Anti-infection
    Metabolic Enzyme/Protease
  2. STING
    Bacterial
    Endogenous Metabolite
  3. c-di-AMP sodium

c-di-AMP sodium (Synonyms: Cyclic diadenylate sodium; Cyclic-di-AMP sodium)

Cat. No.: HY-12326A
Handling Instructions

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.

For research use only. We do not sell to patients.

c-di-AMP sodium Chemical Structure

c-di-AMP sodium Chemical Structure

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Description

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]

In Vitro

c-di-AMP (Cyclic diadenylate) sodium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP sodium is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP sodium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C₂₀H₂₄N₁₀O₁₂P₂.xNa

SMILES

O[[email protected]]([[email protected]@](OP(O)(OC[[email protected]](O[[email protected]@H](N1C2=NC=NC(N)=C2N=C1)[[email protected]@H]3O)([H])[[email protected]@]3([H])O4)=O)([H])[[email protected]](COP4(O)=O)([H])O5)[[email protected]@H]5N6C7=NC=NC(N)=C7N=C6.[x].[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

c-di-AMPCyclic diadenylateCyclic-di-AMPSTINGBacterialEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSendogenousGram-Positivebacteriacell growthsurvivalvirulenceInhibitorinhibitorinhibit

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c-di-AMP sodium
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HY-12326A
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