2. Immunology/Inflammation Anti-infection Metabolic Enzyme/Protease
  3. STING Bacterial Endogenous Metabolite
  4. c-di-AMP disodium

c-di-AMP disodium  (Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium)

Cat. No.: HY-12326A Purity: 99.53%
COA Handling Instructions

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.

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c-di-AMP disodium Chemical Structure

c-di-AMP disodium Chemical Structure

CAS No. : 2734909-87-4

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500 μg USD 120 In-stock
1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 920 In-stock
25 mg USD 1800 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of c-di-AMP disodium:

c-di-AMP disodium Related Antibodies

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Description

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]
In Vitro

c-di-AMP (Cyclic diadenylate) sodium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP sodium is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP sodium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

c-di-AMP disodium Related Antibodies
Molecular Weight

702.38

Appearance

Solid

Formula

C20H22N10Na2O12P2
CAS No.
SMILES

O[C@H]([C@@](OP(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)(O[Na])=O)([H])[C@](COP4(O[Na])=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 270 mg/mL (384.41 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (71.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4237 mL 7.1187 mL 14.2373 mL
5 mM 0.2847 mL 1.4237 mL 2.8475 mL
10 mM 0.1424 mL 0.7119 mL 1.4237 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 6.75 mg/mL (9.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 6.75 mg/mL (9.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 6.75 mg/mL (9.61 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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c-di-AMP disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

c-di-AMP disodium2734909-87-4Cyclic diadenylate disodiumCyclic-di-AMP disodiumSTINGBacterialEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSendogenousGram-Positivebacteriacell growthsurvivalvirulenceInhibitorinhibitorinhibit

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