1. Immunology/Inflammation
  2. STING
  3. c-di-AMP

c-di-AMP (Synonyms: Cyclic diadenylate; Cyclic-di-AMP)

Cat. No.: HY-12326 Purity: 99.29%
Handling Instructions

c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.

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c-di-AMP Chemical Structure

c-di-AMP Chemical Structure

CAS No. : 54447-84-6

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10 mM * 1 mL in DMSO USD 1304 In-stock
Estimated Time of Arrival: December 31
500 μg USD 120 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]

In Vitro

c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

Molecular Weight

658.41

Formula

C₂₀H₂₄N₁₀O₁₂P₂

CAS No.

54447-84-6

SMILES

O[[email protected]]([[email protected]@](OP(O)(OC[[email protected]](O[[email protected]@H](N1C2=NC=NC(N)=C2N=C1)[[email protected]@H]3O)([H])[[email protected]@]3([H])O4)=O)([H])[[email protected]](COP4(O)=O)([H])O5)[[email protected]@H]5N6C7=NC=NC(N)=C7N=C6

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 99.29%

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c-di-AMP
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