1. Immunology/Inflammation
    Anti-infection
    Metabolic Enzyme/Protease
  2. STING
    Bacterial
    Endogenous Metabolite
  3. c-di-AMP diammonium

c-di-AMP diammonium (Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium)

Cat. No.: HY-12326B Purity: 98.55%
Handling Instructions

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.

For research use only. We do not sell to patients.

c-di-AMP diammonium Chemical Structure

c-di-AMP diammonium Chemical Structure

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500 μg USD 120 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]

In Vitro

c-di-AMP diammonium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP diammonium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

692.47

Formula

C₂₀H₃₀N₁₂O₁₂P₂

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References
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Product Name:
c-di-AMP diammonium
Cat. No.:
HY-12326B
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