RIOK3 - RIO kinase 3 Gene

Also Known as SUDD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8780

About RIOK3

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:23,453,287-23,483,140 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 81.4), esophagus (RPKM 38.1) and 24 other tissues.

Summary

This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

RIOK3 Products (2)

mRNA	Protein	Name
NM_001348193.2	NP_001335122.1	serine/threonine-protein kinase RIO3 isoform 2
NM_003831.5	NP_003822.2	serine/threonine-protein kinase RIO3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables caspase binding	IDA IDA: Inferred from direct assay	19557502	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19557502	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	25865883	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to dsDNA	IMP IMP: Inferred from mutant phenotype	24807708	GOA
involved in cellular response to dsRNA	IMP IMP: Inferred from mutant phenotype	24807708	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	24807708	GOA
involved in maturation of SSU-rRNA	IMP IMP: Inferred from mutant phenotype	22418843	GOA
involved in negative regulation of MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	25865883	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19557502	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	25865883	GOA
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	24807708	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	24807708	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of preribosome, small subunit precursor	IDA IDA: Inferred from direct assay	22072790	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOK3 Protein Structure

RIO1

0
100
200
300
400
519 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase RIO3	homolog of the Aspergillus nidulans sudD gene product

RIOK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIOK3	O14730	CASP10	Homo sapiens	Q92851-7	Pull Down	19557502
Intra	RIOK3	O14730	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	24807708
Intra	RIOK3	O14730	IRF3	Homo sapiens	Q14653	Anti Bait CoIP	24807708
Intra	RIOK3	O14730	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	24807708
Intra	RIOK3	O14730	CASP10	Homo sapiens	Q92851	Y2H	19557502
Intra	RIOK3	O14730	CASP10	Homo sapiens	Q92851	Anti Tag CoIP	21988832
Intra	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Y2H	25865883
Intra	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Confocal	25865883
Intra	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	25865883

Cross: Cross-species interaction Intra: Intraspecies interaction

RIOK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810949	RIOK3 Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P89916	SUDD Antibody (YA9260)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Cecum Carcinoma	Cecum Cancer Caecum Carcinoma Carcinoma Of Cecum Cecal Cancer Malignant Neoplasm Of Caecum Malignant Tumor Of The Cecum
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome
Cecum Adenocarcinoma	Cecal Adenocarcinoma Adenocarcinoma Of Cecum
Diverticulitis Of Colon	Colonic Diverticular Disease Diverticulitis, Colonic Diverticular Disease Of Colon
Diverticulitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11990	RIOK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21734	Riok3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28251	Riok3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RIOK3	VGNC	VGNC:53629
Mus musculus	RIOK3	MGD	MGI:1914128
Bos taurus	RIOK3	VGNC	VGNC:49977
Rattus norvegicus	RIOK3	RGD	RGD:1310833
Felis catus	RIOK3	VGNC	VGNC:64638
Macaca mulatta	RIOK3	VGNC	VGNC:104241
Others	RIOK3	NCBI