CASP10 - caspase 10 Gene

Homo sapiens

Also known as MCH4; ALPS2; FLICE2; FLICE-2

Gene ID: 843 | Gene type: protein coding

About CASP10

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,183,141-201,229,406 (from NCBI)

This gene has 15 transcripts (splice variants), 192 orthologues, 16 paralogues and is associated with 5 phenotypes. Broad expression in duodenum (RPKM 6.6), spleen (RPKM 5.9) and 23 other tissues.

Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active Enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by Caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric Cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

CASP10 Products(12)

mRNA	Protein	Name
NM_001230.5	NP_001221.2	caspase-10 isoform 3 preproprotein
XR_923043.3
NM_001206524.2	NP_001193453.1	caspase-10 isoform 6 preproprotein
XR_923044.3
XM_005246907.3	XP_005246964.1	caspase-10 isoform X1
NM_001306083.2	NP_001293012.1	caspase-10 isoform 7
XM_047446016.1	XP_047301972.1	caspase-10 isoform X2
NM_001206542.2	NP_001193471.1	caspase-10 isoform 5 preproprotein
NM_032976.4	NP_116758.1	caspase-10 isoform 4
XR_007082551.1
NM_032977.4	NP_116759.2	caspase-10 isoform 1 preproprotein
NM_032974.5	NP_116756.2	caspase-10 isoform 2 preproprotein

CASP10 Protein Structure

DED

Peptidase_C14

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

caspase-10

CASP-10	FADD-like ICE2
FAS-associated death domain protein interleukin-1B-converting enzyme 2	ICE-like apoptotic protease 4
apoptotic protease MCH-4	caspase 10 apoptosis-related cysteine peptidase
caspase 10, apoptosis-related cysteine protease	interleukin-1B-converting enzyme 2

Recombinant CASP10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7742	Caspase-10/CASP10 Protein, Human (His)	Q92851-4 (V220-R472)	≥95%

Related Diseases

Diseases

Alias

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Clubfoot

Congenital Clubfoot	Congenital Equinovarus
Congenital Talipes Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Cvid9	Immunodeficiency, Common Variable, 9, Formerly
Cvid9, Formerly	Autoimmune Lymphoproliferative Syndrome Type Iii
Common Variable Immunodeficiency 9	Autoimmune Lymphoproliferative Syndrome 3
Immunodeficiency, Common Variable, 9	Type 3 Autoimmune Lymphoproliferative Syndrome
Immunodeficiency, Variable, Common, Type 9

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

Autoimmune Lymphoproliferative Syndrome, Type Iia

Autoimmune Lymphoproliferative Syndrome, Type Ii	Autoimmune Lymphoproliferative Syndrome Type 2a
ALPS2A	Alps2
Autoimmune Lymphoproliferative Syndrome Type Iia	Autoimmune Lymphoproliferative Syndrome 2a

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b	Ceds
Alps2b	Caspase-8 Deficiency
Autoimmune Lymphoproliferative Syndrome, Type Iib	Alps With Recurrent Viral Infections
Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections	Caspase 8 Deficiency Syndrome
Autoimmune Lymphoproliferative Syndrome Type Iib	Caspase Eight Deficiency State
CASP8D

Gastric Cancer

Stomach Cancer	Stomach Carcinoma
Gastric Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01944	CASP10 Human Pre-designed siRNA Set A		/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.