NOTA-Asp2-αvβ6L 

NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC)^[1].

NOTA-Asp2-αvβ6L binds to integrin αvβ6 with high affinity, as indicated by a binding energy of -8.9 kcal/mol^[1].
NOTA-Asp2-αvβ6L (10⁻¹¹ to 10⁻⁴ M; 60 min) competitively binds to [¹⁸F]AlF-NODAGA-αvβ6 binding in 293T-β6 cells with an IC₅₀ of 239.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NOTA-Asp2-αvβ6L ([¹⁸F]AlF-Asp2-αvβ6L) (i.v.; single dose) exhibits favorable in vivo PD properties for PDAC imaging, including rapid tumor accumulation, high in vivo stability, fast renal clearance, and a peak tumor-to-kidney ratio of 0.79 at 120 minutes postinjection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1738.85

C₇₇H₁₁₅N₁₉O₂₇

3107808-75-0

Asp-Leu-Ala-Tyr-{d-Pro}-{Lys-N-Me}-Tyr-Arg-Gly-PEG2-Asp-Asp-NOTA (Lactam bridge: Asp1-Gly9)

DLAY-{d-Pro}-{Lys-N-Me}-YRG-PEG2-DD-NOTA (Lactam bridge: Asp1-Gly9)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang X, et al. Design, Synthesis, and Biological Evaluation of [¹⁸F]AlF-Labeled Integrin αvβ6-Targeting Tracers for Pancreatic Cancer Imaging. J Med Chem. 2025;68(13):14028-14040.  [Content Brief]