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Cat. No.: HY-P11596

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NOTA-Asp2-αvβ6L

NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC).

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CAS No.: 3107808-75-0
화학식: C₇₇H₁₁₅N₁₉O₂₇
분자량:1738.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-Asp2-αvβ6L Chemical Structure

CAS No.: 3107808-75-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

αvβ6

All Integrin Isoforms :

In Vitro

NOTA-Asp2-αvβ6L binds to integrin αvβ6 with high affinity, as indicated by a binding energy of -8.9 kcal/mol^[1].
NOTA-Asp2-αvβ6L (10⁻¹¹ to 10⁻⁴ M; 60 min) competitively binds to [¹⁸F]AlF-NODAGA-αvβ6 binding in 293T-β6 cells with an IC₅₀ of 239.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NOTA-Asp2-αvβ6L ([¹⁸F]AlF-Asp2-αvβ6L) (i.v.; single dose) exhibits favorable in vivo PD properties for PDAC imaging, including rapid tumor accumulation, high in vivo stability, fast renal clearance, and a peak tumor-to-kidney ratio of 0.79 at 120 minutes postinjection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3107808-75-0
분자량 1738.85
화학식 C₇₇H₁₁₅N₁₉O₂₇
Sequence

Asp-Leu-Ala-Tyr-{d-Pro}-{Lys-N-Me}-Tyr-Arg-Gly-PEG2-Asp-Asp-NOTA (Lactam bridge: Asp1-Gly9)
Sequence Shortening

DLAY-{d-Pro}-{Lys-N-Me}-YRG-PEG2-DD-NOTA (Lactam bridge: Asp1-Gly9)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Design, Synthesis, and Biological Evaluation of [¹⁸F]AlF-Labeled Integrin αvβ6-Targeting Tracers for Pancreatic Cancer Imaging. J Med Chem. 2025;68(13):14028-14040. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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