NOTA-Asp2-αvβ6L
NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC).
For research use only. We do not sell to patients.
- CAS No.: 3107808-75-0
- Formula: C77H115N19O27
- Molecular Weight:1738.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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αvβ6 |
NOTA-Asp2-αvβ6L binds to integrin αvβ6 with high affinity, as indicated by a binding energy of -8.9 kcal/mol[1].
NOTA-Asp2-αvβ6L (10−11 to 10−4 M; 60 min) competitively binds to [18F]AlF-NODAGA-αvβ6 binding in 293T-β6 cells with an IC50 of 239.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3107808-75-0
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Molecular Weight 1738.85
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Formula C77H115N19O27
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Sequence
Asp-Leu-Ala-Tyr-{d-Pro}-{Lys-N-Me}-Tyr-Arg-Gly-PEG2-Asp-Asp-NOTA (Lactam bridge: Asp1-Gly9)
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Sequence Shortening
DLAY-{d-Pro}-{Lys-N-Me}-YRG-PEG2-DD-NOTA (Lactam bridge: Asp1-Gly9)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOTA-Asp2-αvβ6L Related Classifications
HY-P11596 Related Classifications
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