RIPK1 - receptor interacting serine/threonine kinase 1 Gene

Also Known as RIP; RIP1; AIEFL; IMD57; RIP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8737

About RIPK1

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:3,063,967-3,115,187 (from NCBI)

This gene has 19 transcripts (splice variants), 198 orthologues, 23 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 7.8), colon (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as Necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

RIPK1 Products (15)

mRNA	Protein	Name
NM_003804.6	NP_003795.2	receptor-interacting serine/threonine-protein kinase 1 isoform 1
NM_001317061.3	NP_001303990.1	receptor-interacting serine/threonine-protein kinase 1 isoform 2
NM_001354930.2	NP_001341859.1	receptor-interacting serine/threonine-protein kinase 1 isoform 1
XM_047419445.1	XP_047275401.1	receptor-interacting serine/threonine-protein kinase 1 isoform X1
NM_001354934.2	NP_001341863.1	receptor-interacting serine/threonine-protein kinase 1 isoform 2
XM_006715237.4	XP_006715300.2	receptor-interacting serine/threonine-protein kinase 1 isoform X3
XM_017011405.2	XP_016866894.1	receptor-interacting serine/threonine-protein kinase 1 isoform X3
NM_001354932.2	NP_001341861.1	receptor-interacting serine/threonine-protein kinase 1 isoform 2
NM_001354931.2	NP_001341860.1	receptor-interacting serine/threonine-protein kinase 1 isoform 3
XM_017011403.2	XP_016866892.1	receptor-interacting serine/threonine-protein kinase 1 isoform X4
NM_001354933.2	NP_001341862.1	receptor-interacting serine/threonine-protein kinase 1 isoform 2
XM_017011404.3	XP_016866893.1	receptor-interacting serine/threonine-protein kinase 1 isoform X5
XM_047419447.1	XP_047275403.1	receptor-interacting serine/threonine-protein kinase 1 isoform X2
XM_047419446.1	XP_047275402.1	receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_047419448.1	XP_047275404.1	receptor-interacting serine/threonine-protein kinase 1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables death domain binding	IPI IPI: Inferred from physical interaction	8612133	GOA
enables death receptor binding	IPI IPI: Inferred from physical interaction	7538908	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22817896	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10356400	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29440439	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	15001576	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22817896	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8612133	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	30988283	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	22265414	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18450452	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	22817896	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	17389591	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	7538908	GOA
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	8612133	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	26020802	GOA
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in necroptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11101870	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17047155	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21525013	GOA
involved in peptidyl-serine autophosphorylation	IDA IDA: Inferred from direct assay	23473668	GOA
involved in peptidyl-serine autophosphorylation	IMP IMP: Inferred from mutant phenotype	31827280	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	8612133	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	8612133	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22173242	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21525013	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26020802	GOA
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	31827280	GOA
involved in positive regulation of interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	31827280	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	17047155	GOA
acts upstream of positive regulation of miRNA processing	IDA IDA: Inferred from direct assay	26020802	GOA
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	22028622	GOA
involved in positive regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	16611992	GOA
involved in positive regulation of programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	20550618	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17389591	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8612133	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	29440439	GOA
involved in protein catabolic process	IDA IDA: Inferred from direct assay	17389591	GOA
involved in regulation of ATP:ADP antiporter activity	IMP IMP: Inferred from mutant phenotype	16507998	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	20550618	GOA
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	10521396	GOA
involved in ripoptosome assembly	IMP IMP: Inferred from mutant phenotype	21737330	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	11101870	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16507998	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22817896	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	8612133	GOA
part of ripoptosome	IDA IDA: Inferred from direct assay	21737330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK1 Protein Structure

Pkinase

RHIM

Death

0
200
400
600
671 a.a.

Protein Preferred Names	Protein Names
receptor-interacting serine/threonine-protein kinase 1	cell death protein RIP receptor (TNFRSF)-interacting serine-threonine kinase 1 receptor-interacting protein 1 receptor-interacting protein kinase 1 serine/threonine-protein kinase RIP

RIPK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	RIPK1	Q13546	UL39	Human herpesvirus 1	U5TQE9	Anti Tag CoIP	26559832
Intra	RIPK1	Q13546	CSNK1A1	Homo sapiens	P48729	Anti Bait CoIP	18067272
Intra	RIPK1	Q13546	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	18067272
Cross	RIPK1	Q13546	P0DTD1-PRO_0000449629	SARS-CoV-2	P0DTD1-PRO_0000449629	Y2H Array	36217030
Cross	RIPK1	Q13546	P0DTD1-PRO_0000449629	SARS-CoV-2	P0DTD1-PRO_0000449629	Anti Bait CoIP	34663909
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	CD	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	26559832
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	19524512
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	19524513
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Fluorescence	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Comigration in SDS	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	GMS	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Anti Bait CoIP	37089942
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Anti Bait CoIP	19524512
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Protein Kinase Assay	19524513
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Pull Down	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	Solid State NMR	22817896
Intra	RIPK1	Q13546	RIPK3	Homo sapiens	Q9Y572	EM	22817896
Intra	RIPK1	Q13546	ANXA1	Homo sapiens	P04083	Anti Bait CoIP	21383699
Intra	RIPK1	Q13546	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	21810480
Intra	RIPK1	Q13546	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	RIPK1	Q13546	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	RIPK1	Q13546	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	RIPK1	Q13546	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	RIPK1	Q13546	TRAF3	Homo sapiens	Q13114	Y2H Array	32296183
Intra	RIPK1	Q13546	TRAF3	Homo sapiens	Q13114	CoIP	8612133
Intra	RIPK1	Q13546	TRAF3	Homo sapiens	Q13114	Y2H Prey Pooling	32296183
Intra	RIPK1	Q13546	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	RIPK1	Q13546	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	RIPK1	Q13546	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	RIPK1	Q13546	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	RIPK1	Q13546	FADD	Homo sapiens	Q13158	Y2H Prey Pooling	32296183
Intra	RIPK1	Q13546	FADD	Homo sapiens	Q13158	Y2H Array	32296183
Intra	RIPK1	Q13546	FADD	Homo sapiens	Q13158	Pull Down	32707033
Intra	RIPK1	Q13546	FADD	Homo sapiens	Q13158	Anti Bait CoIP	21525013
Intra	RIPK1	Q13546	FADD	Homo sapiens	Q13158	Anti Bait CoIP	21458669
Intra	RIPK1	Q13546	CASP10	Homo sapiens	Q92851	Pull Down	12884866
Intra	RIPK1	Q13546	BIRC3	Homo sapiens	Q13489	Anti Tag CoIP	21931591
Intra	RIPK1	Q13546	USP4	Homo sapiens	Q13107	Anti Tag CoIP	23313255
Intra	RIPK1	Q13546	CCDC50	Homo sapiens	Q8IVM0	Anti Tag CoIP	18029035
Intra	RIPK1	Q13546	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	21458669
Intra	RIPK1	Q13546	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	21383699
Intra	RIPK1	Q13546	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	14653779

Cross: Cross-species interaction Intra: Intraspecies interaction

RIPK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80313	RIP Antibody (YA091)	WB, FC	Human
HY-P810740	Cleaved-RIP (Asp324) Antibody (YA9983)	WB	Human, Mouse, Rat
HY-P81539	Phospho-RIP(S166) Antibody (YA1284)	WB, IHC-P, IHC-F, ICC/IF, IP	Mouse
HY-P84549	RIP Antibody (YA4246)	WB, ELISA	Human
HY-P84549A	RIP Antibody (YA4246)(PBS only)	WB, ELISA	Human
HY-P86619	RIP Antibody (YA6311)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Glycogen Storage Disease Iv	Gsd Iv Glycogen Branching Enzyme Deficiency Andersen Disease Amylopectinosis Glycogen Storage Disease Type Iv GSD4 Brancher Deficiency Glycogen Storage Disease, Type Iv Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gbe1 Deficiency Glycogenosis Iv Cirrhosis, Familial, With Deposition Of Abnormal Glycogen Glycogen Storage Disease Type 4 Glycogenosis 4 Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features Andersen'S Disease Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Brancher Deficiency Glycogenosis Branching-Transferase Deficiency Glycogenosis Deficiency Of 1,4-Alpha-Glucan Branching Enzyme Andersen-Tawil Syndrome Gsd 4 Andersen Cardiodysrhythmic Periodic Paralysis Lqt7 Long Qt Syndrome 7 Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Andersen Glycogenosis Branching Enzyme Deficiency Glycogenosis, Type Iv Gsd Type Iv Type Iv Glycogenosis Gbe Deficiency, Childhood Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Gsd Type 4, Childhood Neuromuscular Form Gsdiv, Childhood Neuromuscular Form Glycogen Storage Disease Type 4, Childhood Neuromuscular Form Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogenosis Type 4, Childhood Neuromuscular Form Glycogenosis Type Iv, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gbe Deficiency, Adult Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gsd Type 4, Adult Neuromuscular Form Gsdiv, Adult Neuromuscular Form Glycogen Storage Disease Type 4, Adult Neuromuscular Form Glycogen Storage Disease Type Iv, Adult Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Glycogenosis Type 4, Adult Neuromuscular Form Glycogenosis Type Iv, Adult Neuromuscular Form Gbe Deficiency, Congenital Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gsd Type 4, Congenital Neuromuscular Form Gsdiv, Congenital Neuromuscular Form Glycogen Storage Disease Type 4, Congenital Neuromuscular Form Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Glycogenosis Type 4, Congenital Neuromuscular Form Glycogenosis Type Iv, Congenital Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Type 4, Childhood Combined Hepatic And Myopathic Form Gsdiv, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Fatal Perinatal Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Gsd Type 4, Fatal Perinatal Neuromuscular Form Gsdiv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gbe Deficiency, Non Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gsd Type 4, Non Progressive Hepatic Form Gsdiv, Non Progressive Hepatic Form Glycogen Storage Disease Type 4, Non Progressive Hepatic Form Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Glycogenosis Type 4, Non Progressive Hepatic Form Glycogenosis Type Iv, Non Progressive Hepatic Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gbe Deficiency, Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gsd Type 4, Progressive Hepatic Form Gsdiv, Progressive Hepatic Form Glycogen Storage Disease Type 4, Progressive Hepatic Form Glycogen Storage Disease Type Iv, Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Glycogenosis Type 4, Progressive Hepatic Form Glycogenosis Type Iv, Progressive Hepatic Form Glycogen Storage Disease 4 Gsd-Iv Storage Disease, Glycogen, Type Iv
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Immunodeficiency 57 With Autoinflammation	Immunodeficiency 57 IMD57 Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections-Lymphopenia Syndrome
Inflammatory Bowel Disease 25, Autosomal Recessive	Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome IBD25 Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive Il10-Related Early-Onset Ibd Il10-Related Early-Onset Inflammatory Bowel Disease Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive Autosomal Recessive Early-Onset Inflammatory Bowel Disease Autosomal Recessive Early-Onset Ibd Early-Onset Autosomal Recessive Inflammatory Bowel Disease Bowel Disease, Inflammatory, Type 25, Autosomal Recessive
Autoinflammation With Episodic Fever And Lymphadenopathy	AIEFL Cleavage-Resistant Ripk1-Induced Autoinflammatory Syndrome Cria Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Lymphopenia	Lymphocytopenia
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Otulipenia Otulin-Related Autoinflammatory Syndrome AIPDS Oras Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome Autoinflammation, Panniculitis And Dermatosis Syndrome Otulin Deficiency
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114371	Eclitasertib	Inhibitor	99.80%	Phase 2
HY-148787	Oditrasertib	Inhibitor	99.84%	Phase 2
HY-148297	Ocadusertib	Inhibitor	99.57%	Phase 2
HY-152846	Flizasertib	Inhibitor	99.9%	Phase 2

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14622A	Necrostatin 2 racemate	Inhibitor	99.57%	Unkown
HY-134050	Apostatin-1	Inhibitor	99.64%	Unkown
HY-138779	ICCB-19 hydrochloride	Inhibitor	99.25%	Unkown
HY-14622	Necrostatin 2	Inhibitor	99.78%	Unkown
HY-N0546	Ligustroflavone	Inhibitor	99.90%	Unkown
HY-124546	Necrostatin-5	Inhibitor	99.40%	Unkown
HY-153598	LD4172	Degrader	98.32%	Unkown
HY-128348	PK68	Inhibitor	99.92%	Unkown
HY-18901	RIPK1-IN-4	Inhibitor	98.89%	Unkown
HY-161059	ZB-R-55	Inhibitor	99.39%	Unkown
HY-161060	Zharp1-211	Inhibitor	99.15%	Unkown
HY-157039	RIPK1-IN-17	Inhibitor	97.09%	Unkown
HY-14622B	Necrostatin 2 (S enantiomer)	Inhibitor	99.76%	Unkown
HY-157456	RIPK1-IN-19	Inhibitor	98.87%	Unkown
HY-120548	KBU2046		98.85%	Unkown
HY-151873	SZM679	Inhibitor	99.59%	Unkown
HY-148365	NecroIr1	Activator	98.53%	Unkown
HY-149258	KWCN-41	Inhibitor	99.83%	Unkown
HY-148366	NecroIr2	Activator	98.02%	Unkown
HY-132203	Necrostatin-34	Inhibitor	98.90%	Unkown
HY-175370	PROTAC RIPK1 Degrader-1	Degrader	99.66%	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-175007	RIPK1-IN-32	Inhibitor	/	Unkown
HY-173185	RIP1-IN-1	Inhibitor	/	Unkown
HY-153437	PB830	Inhibitor	/	Unkown
HY-143726	RIPK1-IN-8	Inhibitor	/	Unkown
HY-179323	RIPK1-IN-36	Inhibitor	/	Unkown
HY-179680	RIPK1-IN-38	Inhibitor	/	Unkown
HY-181596	WJH-C19	Inhibitor	98.65%	Unkown
HY-162237	RIPK1-IN-22	Inhibitor	/	Unkown
HY-181062	VWK147	Inhibitor	/	Unkown
HY-180806	RIPK1-IN-39	Inhibitor	/	Unkown
HY-149052	SZM-1209	Inhibitor	/	Unkown
HY-160216	RIPK1-IN-18	Inhibitor	/	Unkown
HY-W319332	Necrostatin-21	Inhibitor	/	Unkown
HY-179235	RIPK1-IN-37	Inhibitor	/	Unkown
HY-146758	RIPK1-IN-14	Inhibitor	/	Unkown
HY-178163	Zharp1-163	Inhibitor	/	Unkown
HY-153434	RIP1 kinase inhibitor 4	Inhibitor	/	Unkown
HY-169107	RIPK1-IN-25	Inhibitor	/	Unkown
HY-157963	RIPK1-IN-23	Inhibitor	/	Unkown
HY-173574	RIPK1-IN-31	Modulator	/	Unkown
HY-184001	LT-1339-553	Inhibitor	/	Unkown
HY-170232	RIPK1-IN-29	Inhibitor	/	Unkown
HY-178762S	RIPK1-IN-35	Inhibitor	/	Unkown
HY-144276	RIPK1-IN-11	Inhibitor	/	Unkown
HY-183564	RIPK1/RIPK3-PPI-IN-1	Inhibitor	/	Unkown
HY-184686	RIPK1-IN-42	Inhibitor	/	Unkown
HY-P10977	Tat-ASIC1a (1-20) (mouse, rat)	Inhibitor	/	Unkown
HY-161911	Necroptosis-IN-5	Inhibitor	/	Unkown
HY-178464	RIPK1-IN-34	Inhibitor	/	Unkown
HY-181944	RIPK1-IN-40	Inhibitor	/	Unkown
HY-175371	RIPK1-ligand-2	Inhibitor	/	Unkown
HY-183781	RIPK1-IN-41	Inhibitor	/	Unkown
HY-18899	Nec-3a	Inhibitor	/	Unkown
HY-175374	RIPK1 ligand-Linker Conjugate-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RIPK1	VGNC	VGNC:64640
Macaca mulatta	RIPK1	VGNC	VGNC:76695
Rattus norvegicus	RIPK1	RGD	RGD:1310158
Mus musculus	RIPK1	MGD	MGI:108212
Bos taurus	RIPK1	VGNC	VGNC:33981
Canis familiaris	RIPK1	VGNC	VGNC:45594
Others	RIPK1	NCBI