1. Apoptosis
  2. RIP kinase
  3. PK68

PK68 

Cat. No.: HY-128348
Handling Instructions

PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis.

For research use only. We do not sell to patients.

PK68 Chemical Structure

PK68 Chemical Structure

CAS No. : 2173556-69-7

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Description

PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1].

IC50 & Target

IC50: ~ 90 nM (RIPK1)[1]

Molecular Weight

424.52

Formula

C₂₂H₂₄N₄O₃S

CAS No.

2173556-69-7

SMILES

O=C(OC1CCCCC1)NC2=CC(C3=CC=C4N=C(NC(C)=O)SC4=C3)=CN=C2C

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PK68
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HY-128348
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