1. Apoptosis
  2. RIP kinase
  3. RIPK1-IN-4

RIPK1-IN-4 

Cat. No.: HY-18901
Handling Instructions

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase.

For research use only. We do not sell to patients.

RIPK1-IN-4 Chemical Structure

RIPK1-IN-4 Chemical Structure

CAS No. : 1481641-08-0

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Description

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].

IC50 & Target

IC50: 16 nM (RIP1) and 10 nM (ADP-Glo)[1]

Molecular Weight

401.46

Formula

C₂₃H₂₃N₅O₂

CAS No.

1481641-08-0

SMILES

CC(C)(C1=CC(NC(NC2=CC=C(C3=CC=CC4=C3C=CN=C4N)C=C2)=O)=NO1)C

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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RIPK1-IN-4
Cat. No.:
HY-18901
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