1481641-08-0
1481641-08-0
Chemical Structure
RIPK1-IN-4
- CAS No.: 1481641-08-0
- Formula:C23H23N5O2
- Molecular Weight:401.46
IUPAC Name: 1-(4-(1-aminoisoquinolin-5-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea
InChIKey: SLRYMOUSQMDJPH-UHFFFAOYSA-N
SMILES: CC(C)(C1=CC(NC(NC2=CC=C(C3=CC=CC4=C3C=CN=C4N)C=C2)=O)=NO1)C
Biological Activity: RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].
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RIPK1-IN-4 | 98.89% | RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase. | ||||||||||||||||||||
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References
Keywords
