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WEHI-345 Chemical Structure
|Product name: WEHI-345|
|Cat. No.: HY-18937|
WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
IC50 value: 0.13 μM
in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5.
in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line.
|M.Wt||401.46||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 32 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.4909 mL||12.4545 mL||24.9091 mL|
|5 mM||0.4982 mL||2.4909 mL||4.9818 mL|
|10 mM||0.2491 mL||1.2455 mL||2.4909 mL|
GSK(acute)481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.
GSK583 is a highly potent and selective inhibitor of RIP2 Kinase.
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-(alpha)-induced necroptosis with EC50 of 490 nM.
RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.