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Signaling Pathway




WEHI-345 Chemical Structure

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.


CAS No.: 1354825-58-3 Backordered

Size Price Stock Quantity
5 mg $350 Backordered
10 mg $500 Backordered
50 mg $1500 Backordered
100 mg $2100 Backordered

WEHI-345 analog

CAS No.: 1354825-62-9 In-stock

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Inquiry Information
Product name: WEHI-345
Cat. No.: HY-18937

WEHI-345 Data Sheet

  • Network Version


Related Compound Libraries

Biological Activity of WEHI-345

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
IC50 value: 0.13 μM
Target: RIPK2
in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5.
in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line.

Protocol (Extracted from published papers and Only for reference)


Chemical Information

M.Wt 401.46 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H23N7O
CAS No 1354825-58-3
Solvent & Solubility

DMSO: ≥ 30 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4909 mL 12.4545 mL 24.9091 mL
5 mM 0.4982 mL 2.4909 mL 4.9818 mL
10 mM 0.2491 mL 1.2455 mL 2.4909 mL

References on WEHI-345

Inhibitor Kit

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