RIPK1-IN-40
RIPK1-IN-40 (Compound 51) is a RIPK1 inhibitor and anti-necroptotic agent (with an EC50 of 0.07 μM against necroptosis). RIPK1-IN-40 binds to the kinase domain of RIPK1, forms hydrogen bond interactions with Met95, and establishes additional polar contacts with Asp156 to stabilize binding, thereby inhibiting necroptosis. RIPK1-IN-40 can be used for the research of colorectal cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C27H18F5N3O3S
- Masse moléculaire:559.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
RIPK1 |
In Vitro
RIPK1-IN-40 (24 h) potently inhibits TNF-induced necroptosis in HT-29 cells via favorable binding interactions with RIPK1 residues Met95 and Asp156, with an EC50 of 0.07 ± 0.01 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 559.51
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Formule C27H18F5N3O3S
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SMILES
O=C(C1CC(C1)=O)NC2=NC3=CC(F)=C(C4=CC=C(F)C(NC(CC5=CC=CC(C(F)(F)F)=C5)=O)=C4)C=C3S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RIPK1-IN-40 Related Classifications
HY-181944 Related Classifications
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