RIPK1-IN-40
RIPK1-IN-40 (Compound 51) is a RIPK1 inhibitor and anti-necroptotic agent (with an EC50 of 0.07 μM against necroptosis). RIPK1-IN-40 binds to the kinase domain of RIPK1, forms hydrogen bond interactions with Met95, and establishes additional polar contacts with Asp156 to stabilize binding, thereby inhibiting necroptosis. RIPK1-IN-40 can be used for the research of colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C27H18F5N3O3S
- Molecular Weight:559.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RIPK1 |
RIPK1-IN-40 (24 h) potently inhibits TNF-induced necroptosis in HT-29 cells via favorable binding interactions with RIPK1 residues Met95 and Asp156, with an EC50 of 0.07 ± 0.01 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 559.51
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Formula C27H18F5N3O3S
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SMILES
O=C(C1CC(C1)=O)NC2=NC3=CC(F)=C(C4=CC=C(F)C(NC(CC5=CC=CC(C(F)(F)F)=C5)=O)=C4)C=C3S2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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