CSNK1A1 - casein kinase 1 alpha 1 Gene

Also Known as CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1452

About CSNK1A1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,492,982-149,551,439 (from NCBI)

This gene has 17 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

CSNK1A1 Products (4)

mRNA	Protein	Name
NM_001025105.3	NP_001020276.1	casein kinase I isoform alpha isoform 1
NM_001271741.2	NP_001258670.1	casein kinase I isoform alpha isoform 3
NM_001271742.2	NP_001258671.1	casein kinase I isoform alpha isoform 4
NM_001892.6	NP_001883.4	casein kinase I isoform alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16511560	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	32645325	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18305108	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	11955436	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	25500533	GOA
involved in cellular response to nutrient	IDA IDA: Inferred from direct assay	22017875	GOA
involved in intermediate filament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23902688	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21331045	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	11955436	GOA
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	25500533	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	22017875	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19364825	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	11955436	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18305108	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	11955436	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
colocalizes with keratin filament	IDA IDA: Inferred from direct assay	23902688	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	18305108	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	18305108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1A1 Protein Structure

Pkinase

0
100
200
300
337 a.a.

Protein Preferred Names	Protein Names
casein kinase I isoform alpha	CKI-alpha

CSNK1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	Anti Bait CoIP	29789297
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	Anti Tag CoIP	35271311
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	Pull Down	32707033
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	Anti Tag CoIP	33961781
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	IF	29789297
Intra	CSNK1A1	P48729	FAM83G	Homo sapiens	A6ND36	TAP	23455922
Intra	CSNK1A1	P48729	MALT1	Homo sapiens	Q9UDY8	Anti Bait CoIP	19118383
Intra	CSNK1A1	P48729	FAM83C	Homo sapiens	Q9BQN1	IF	29789297
Intra	CSNK1A1	P48729	FAM83F	Homo sapiens	Q8NEG4	IF	29789297
Intra	CSNK1A1	P48729	FAM83F	Homo sapiens	Q8NEG4	Anti Tag CoIP	29789297
Intra	CSNK1A1	P48729	FAM83D	Homo sapiens	Q9H4H8	Anti Tag CoIP	29789297
Intra	CSNK1A1	P48729	FAM83D	Homo sapiens	Q9H4H8	Anti Tag CoIP	33961781
Intra	CSNK1A1	P48729	FAM83D	Homo sapiens	Q9H4H8	TAP	23455922
Intra	CSNK1A1	P48729	FAM83D	Homo sapiens	Q9H4H8	IF	29789297
Intra	CSNK1A1	P48729	FAM83D	Homo sapiens	Q9H4H8	Anti Tag CoIP	35271311
Intra	CSNK1A1	P48729	FAM83H	Homo sapiens	Q6ZRV2	Anti Tag CoIP	33961781
Intra	CSNK1A1	P48729	FAM83H	Homo sapiens	Q6ZRV2	TAP	23455922
Intra	CSNK1A1	P48729	FAM83H	Homo sapiens	Q6ZRV2	Pull Down	32707033
Intra	CSNK1A1	P48729	FAM83H	Homo sapiens	Q6ZRV2	Anti Tag CoIP	35271311
Intra	CSNK1A1	P48729	FAM83H	Homo sapiens	Q6ZRV2	Anti Bait CoIP	29789297
Intra	CSNK1A1	P48729	FAM83B	Homo sapiens	Q5T0W9	TAP	23455922
Intra	CSNK1A1	P48729	FAM83B	Homo sapiens	Q5T0W9	Pull Down	32707033
Intra	CSNK1A1	P48729	FAM83B	Homo sapiens	Q5T0W9	Anti Tag CoIP	35271311
Intra	CSNK1A1	P48729	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	CSNK1A1	P48729	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CSNK1A1	P48729	RIPK1	Homo sapiens	Q13546	Protein Kinase Assay	18067272
Intra	CSNK1A1	P48729	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	18067272
Intra	CSNK1A1	P48729	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	CSNK1A1	P48729	MDM2	Homo sapiens	Q00987	Pull Down	20708156
Intra	CSNK1A1	P48729	MDM4	Homo sapiens	O15151	Affinity Chrom	17110929
Intra	CSNK1A1	P48729	MDM4	Homo sapiens	O15151	Anti Tag CoIP	16511560
Intra	CSNK1A1	P48729	MDM4	Homo sapiens	O15151	Anti Tag CoIP	35271311
Intra	CSNK1A1	P48729	CARD11	Homo sapiens	Q9BXL7	Anti Bait CoIP	19118383

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSNK1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72872	CSNK1A1/Casein Kinase I alpha Protein, Human (Active, sf9, GST)	P48729-1 (M1-F337)	≥ 90%, as determined by reducing SDS-PAGE.

CSNK1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80585	Casein Kinase 1 alpha Antibody (YA564)	WB, IP	Human, Rat
HY-P80585A	Casein Kinase 1 alpha Antibody (YA564)(PBS only)	WB, IP	Human, Rat
HY-P85075	Casein Kinase 1 alpha Antibody (YA4767)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Enterobiasis	Oxyuriasis Pinworm Infection Enterobius Vermicularis Infection Threadworm Infection Oxyuris Vermicularis Infection Enterobiosis Pinworm Pinworm Disease Seatworm Infection Enterobiasis Threadworm Pinworm Infestation Seatworm
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145939	BAY-888	Inhibitor	98.27%	Unkown
HY-148491	CSNK1-IN-2	Inhibitor	99.22%	Unkown
HY-137340	WH-10417-099	Degrader	98.14%	Unkown
HY-148489	CSNK1-IN-1	Inhibitor	99.63%	Unkown
HY-RS03245	CSNK1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175600	MI-2-80	Degrader	/	Unkown
HY-RS03248	CSNK1G1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17153	Csnk1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21999	Csnk1g1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23603	Csnk1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28516	Csnk1g1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CSNK1A1	VGNC	VGNC:84290
Bos taurus	CSNK1A1	VGNC	VGNC:55205
Mus musculus	CSNK1A1	MGD	MGI:1934950
Felis catus	CSNK1A1	VGNC	VGNC:102183
Rattus norvegicus	CSNK1A1	RGD	RGD:71098
Others	CSNK1A1	NCBI