BAY-888
Based on 1 Customer Validation
BAY-888 is a selective CK1α/CSNK1A1 (casein kinase 1α) ATP-competitive inhibitor (IC50: 4 nM@10 μM ATP; 63 nM@1 mM ATP). BAY-888 blocks the negative regulation of p53 and other signaling pathways by CK1α, induces apoptosis and inhibits proliferation of tumor cells. BAY-888 has shown inhibitory efficacy against cancers such as acute myeloid leukemia (AML) in PRISM barcoded cell line screening and can mimic the effects of shRNA-mediated CK1α knockdown. BAY-888 is primarily used for the development of anticancer drugs for p53 wild-type tumors and for the study of the mechanisms of CK1α-related signaling pathways.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.27%
- CAS 番号: 2468783-75-5
- 分子式: C28H26FN5O2
- 分子量:483.54
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2468783-75-5
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性状 Solid
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分子量 483.54
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分子式 C28H26FN5O2
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Color Light brown to yellow
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SMILES
O=C1C2=C(NC(C3=CC=NC(NC([C@@H](C)C4=CC=C(F)C=C4)=O)=C3)=C2NC5=CC=CC=C5)CCN1C
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別名
BRD5846
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 50 mg/mL (103.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0681 mL | 10.3404 mL | 20.6808 mL | 51.7020 mL |
| 5 mM | 0.4136 mL | 2.0681 mL | 4.1362 mL | 10.3404 mL | |
| 10 mM | 0.2068 mL | 1.0340 mL | 2.0681 mL | 5.1702 mL | |
| 15 mM | 0.1379 mL | 0.6894 mL | 1.3787 mL | 3.4468 mL | |
| 20 mM | 0.1034 mL | 0.5170 mL | 1.0340 mL | 2.5851 mL | |
| 25 mM | 0.0827 mL | 0.4136 mL | 0.8272 mL | 2.0681 mL | |
| 30 mM | 0.0689 mL | 0.3447 mL | 0.6894 mL | 1.7234 mL | |
| 40 mM | 0.0517 mL | 0.2585 mL | 0.5170 mL | 1.2926 mL | |
| 50 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0340 mL | |
| 60 mM | 0.0345 mL | 0.1723 mL | 0.3447 mL | 0.8617 mL | |
| 80 mM | 0.0259 mL | 0.1293 mL | 0.2585 mL | 0.6463 mL | |
| 100 mM | 0.0207 mL | 0.1034 mL | 0.2068 mL | 0.5170 mL |
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