Casein Kinase 1 alpha Antibody (YA4767)
(Synonyms: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1)Casein Kinase 1 alpha Antibody (YA4767) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Casein Kinase 1 alpha.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
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| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 | 1:50-200 |
Product Details
Casein Kinase 1 alpha Antibody (YA4767) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Casein Kinase 1 alpha.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 39 kDa;
Purified recombinant fragment of Casein Kinase Iα expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Casein Kinase 1 alpha is a Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus speckle; Cytoplasm, cytoskeleton, cilium basal body; Cytoplasm, cytoskeleton, spindle
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Isoforms & Post-Translational Modification
P48729 has 3 isomers: P48729-1: 38915 Da (predicted); P48729-2: 41937 Da (predicted); P48729-3: 37567 Da (predicted).
Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation -
Subunit
Interacts with the Axin complex (PubMed:11955436). Interacts with TUT1, leading to TUT1 phosphorylation (PubMed:1409656).
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SwissProt ID
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Synonyms
CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1
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