CARD11 - caspase recruitment domain family member 11 Gene

Also Known as PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84433

About CARD11

Cytogenetic location: 7p22.2 Genomic coordinates (GRCh38): 7:2,906,142-3,043,867 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 133 phenotypes. Biased expression in lymph node (RPKM 19.0), spleen (RPKM 15.1) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell Apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

CARD11 Products (2)

mRNA	Protein	Name
NM_001324281.3	NP_001311210.1	caspase recruitment domain-containing protein 11
NM_032415.7	NP_115791.3	caspase recruitment domain-containing protein 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11278692	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12154360	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell costimulation	IDA IDA: Inferred from direct assay	17287217	GOA
involved in TORC1 signaling	IMP IMP: Inferred from mutant phenotype	28628108	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	28628108	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	24074955	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12154360	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12154360	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12154360	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	12154360	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	24074955	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CBM complex	IDA IDA: Inferred from direct assay	24074955	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12154360	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	12154360	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12154360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD11 Protein Structure

CARD

0
200
400
600
800
1000
1154 a.a.

Protein Preferred Names	Protein Names
caspase recruitment domain-containing protein 11	CARD-containing MAGUK protein 1

CARD11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CARD11	Q9BXL7	CSNK1A1	Homo sapiens	P48729-1	Anti Tag CoIP	19118383
Intra	CARD11	Q9BXL7	MALT1	Homo sapiens	Q9UDY8	Anti Tag CoIP	17948050
Intra	CARD11	Q9BXL7	MALT1	Homo sapiens	Q9UDY8	Anti Tag CoIP	22528498
Intra	CARD11	Q9BXL7	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	19118383
Intra	CARD11	Q9BXL7	CBLB	Homo sapiens	Q13191-1	Anti Tag CoIP	19815501
Cross	CARD11	Q9BXL7	Map4k1	Mus musculus	P70218	Anti Tag CoIP	19706536
Intra	CARD11	Q9BXL7	PRKCD	Homo sapiens	Q05655	Anti Bait CoIP	22528498
Intra	CARD11	Q9BXL7	PRKCD	Homo sapiens	Q05655	Anti Tag CoIP	22528498
Intra	CARD11	Q9BXL7	PRKCD	Homo sapiens	Q05655	Confocal	22528498
Intra	CARD11	Q9BXL7	PRKCD	Homo sapiens	Q05655	TAP	22528498
Intra	CARD11	Q9BXL7	BCL10	Homo sapiens	O95999	Anti Bait CoIP	19444310
Intra	CARD11	Q9BXL7	BCL10	Homo sapiens	O95999	Anti Tag CoIP	22528498

Cross: Cross-species interaction Intra: Intraspecies interaction

CARD11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82870	CARD11 Antibody (YA2615)	WB, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Immunodeficiency 11	Immunodeficiency 11a Severe Combined Immunodeficiency Due To Card11 Deficiency IMD11A Imd11 Card11 Immunodeficiency Scid Due To Card11 Deficiency Card11 Deficiency Immunodeficiency 11 A
Immunodeficiency 11b With Atopic Dermatitis	IMD11B Atopic Dermatitis, Elevated Ige, And Eosinophilia Immunodeficiency 11b
Splenomegaly
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Persistent Polyclonal B-Cell Lymphocytosis	PPBL Persistent Polyclonal B-Cell Lymphocytosis With Binucleated Lymphocytes Lymphocytosis, B-Cell, Polyclonal, Persistent
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Colon Squamous Cell Carcinoma	Colonic Epidermoid Carcinoma Squamous Cell Carcinoma Of Colon Squamous Cell Carcinoma Of The Colon
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Colorectal Adenocarcinoma	Adenocarcinoma Of Large Intestine
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
St2 Diffuse Large B-Cell Lymphoma	St2 Dlbcl Doid:0081068
Testicular Lymphoma	Malignant Lymphoma Of Testis Lymphoma Of The Testis
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Ezb Diffuse Large B-Cell Lymphoma	Ezb Dlbcl Doid:0081065
Immunodeficiency 58	IMD58 Severe Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Rltpr Deficiency
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Pityriasis Rubra Pilaris	PRP Devergie'S Disease Prp - [Pityriasis Rubra Pilaris]
Adult T-Cell Leukemia/Lymphoma	Adult T-Cell Leukemia Atll Adult T-Cell Leukaemia Adult T-Cell Leukaemia/Lymphoma Adult T-Cell Lymphoma T Cell Leukemia Lymphoma Adult Leukemia-Lymphoma, Adult T-Cell Leukemia, T-Cell Adult T-Cell Lymphoma/Leukemia
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142648	MLT-985	Inhibitor	99.49%	Unkown
HY-174371	INNO-220		98.60%	Unkown
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-182706	NSC 373981	Inhibitor	/	Unkown
HY-RS01916	CARD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17847	Card11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24315	Card11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CARD11	RGD	RGD:2323211
Macaca mulatta	CARD11	VGNC	VGNC:70568
Felis catus	CARD11	VGNC	VGNC:60364
Bos taurus	CARD11	VGNC	VGNC:26761
Mus musculus	CARD11	MGD	MGI:1916978
Canis familiaris	CARD11	VGNC	VGNC:38714
Others	CARD11	NCBI