PRKCD - protein kinase C delta Gene

Also Known as MAY1; PKCD; ALPS3; CVID9; nPKC-delta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5580

About PRKCD

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,161,209-53,192,717 (from NCBI)

This gene has 14 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate Apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

PRKCD Products (16)

mRNA	Protein	Name
XM_047448564.1	XP_047304520.1	protein kinase C delta type isoform X1
NM_001354679.2	NP_001341608.1	protein kinase C delta type isoform c
NM_001316327.2	NP_001303256.1	protein kinase C delta type isoform c
NM_001354680.2	NP_001341609.1	protein kinase C delta type isoform c
NM_212539.2	NP_997704.1	protein kinase C delta type isoform c
NM_001354676.2	NP_001341605.1	protein kinase C delta type isoform a
NM_006254.4	NP_006245.2	protein kinase C delta type isoform c
XR_007095706.1
NM_001354678.2	NP_001341607.1	protein kinase C delta type isoform b
NM_001316327.2	NP_001303256.1	protein kinase C delta type isoform c
NM_001354676.2	NP_001341605.1	protein kinase C delta type isoform a
NM_001354678.2	NP_001341607.1	protein kinase C delta type isoform b
NM_001354679.2	NP_001341608.1	protein kinase C delta type isoform c
NM_001354680.2	NP_001341609.1	protein kinase C delta type isoform c
NM_006254.4	NP_006245.2	protein kinase C delta type isoform c
NM_212539.2	NP_997704.1	protein kinase C delta type isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12391145	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	16611985	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	18556656	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16611985	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9139733	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	24008408	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10713049	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	17303575	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10770950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17938203	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	10713049	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	10770950	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	17303575	GOA
involved in cellular response to angiotensin	IDA IDA: Inferred from direct assay	18285462	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	10713049	GOA
involved in cellular response to hydroperoxide	IDA IDA: Inferred from direct assay	19059439	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	15282327	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	19279008	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15774464	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	10770950	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18285462	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	10770950	GOA
involved in positive regulation of ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	19059439	GOA
involved in positive regulation of glucosylceramide catabolic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of phospholipid scramblase activity	IMP IMP: Inferred from mutant phenotype	10770950	GOA
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	19059439	GOA
involved in positive regulation of sphingomyelin catabolic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	19801500	GOA
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	19059439	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10713049	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22554282	GOA
involved in regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	17303575	GOA
involved in termination of signal transduction	IMP IMP: Inferred from mutant phenotype	19279008	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10770950	GOA
located in endolysosome	IDA IDA: Inferred from direct assay	17303575	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15774464	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15632189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10770950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCD Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
676 a.a.

Protein Preferred Names	Protein Names
protein kinase C delta type	protein kinase C delta VIII tyrosine-protein kinase PRKCD

PRKCD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKCD	Q05655	GAP43	Homo sapiens	P17677	Anti Bait CoIP	9139733
Intra	PRKCD	Q05655	GAP43	Homo sapiens	P17677	Protein Kinase Assay	9139733
Intra	PRKCD	Q05655	TP53	Homo sapiens	P04637	Pull Down	16377624
Intra	PRKCD	Q05655	TP53	Homo sapiens	P04637	Protein Kinase Assay	16377624
Intra	PRKCD	Q05655	TP53	Homo sapiens	P04637	Anti Bait CoIP	16377624
Intra	PRKCD	Q05655	FYN	Homo sapiens	P06241	Protein Kinase Assay	10383400
Intra	PRKCD	Q05655	FYN	Homo sapiens	P06241	Anti Bait CoIP	12721299
Intra	PRKCD	Q05655	FYN	Homo sapiens	P06241	ELISA	10383400
Intra	PRKCD	Q05655	DIABLO	Homo sapiens	Q9NR28	Anti Bait CoIP	22465666
Intra	PRKCD	Q05655	TOP2A	Homo sapiens	P11388	Pull Down	16611985
Intra	PRKCD	Q05655	TOP2A	Homo sapiens	P11388	Anti Bait CoIP	16611985
Intra	PRKCD	Q05655	TOP2A	Homo sapiens	P11388	Anti Tag CoIP	16611985
Intra	PRKCD	Q05655	TOP2A	Homo sapiens	P11388	Protein Kinase Assay	16611985
Intra	PRKCD	Q05655	IL32	Homo sapiens	P24001-2	Anti Bait CoIP	23814099
Intra	PRKCD	Q05655	IL32	Homo sapiens	P24001-2	IF	24396867
Intra	PRKCD	Q05655	IL32	Homo sapiens	C6GKH1	IF	24996056
Intra	PRKCD	Q05655	IL32	Homo sapiens	C6GKH1	Anti Tag CoIP	24996056

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKCD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80433	PKC delta Antibody (YA128)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P82883	Phospho-PKC delta (Ser299) Antibody (YA2628)	WB, IHC-P	Human
HY-P82883A	Phospho-PKC delta (Ser299) Antibody (YA2628)(PBS only)	WB, IHC-P, IP	Human
HY-P86328	PKC delta Antibody (YA6020)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lymphoproliferative Syndrome 3	LPFS3 Cd70 Deficiency Combined Immunodeficiency Due To Cd70 Deficiency Cid Due To Cd70 Deficiency
Glioma
Diabetes Mellitus	Diabetes
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Craniometaphyseal Dysplasia, Autosomal Dominant	Craniometaphyseal Dysplasia CMDD Cmdj Cmd Autosomal Dominant Craniometaphyseal Dysplasia Craniometaphyseal Dysplasia, Jackson Type Craniometaphyseal Dysplasia Jackson Type Autosomal Recessive Craniometaphyseal Dysplasia Cmdr Dysplasia, Craniometaphyseal, Autosomal Dominant Craniometaphyseal Dysplasia, Autosomal Recessive Type
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Systemic Lupus Erythematosus 16	SLEB16 Autosomal Systemic Lupus Erythematosus Autosomal Sle Familial Sle Familial Systemic Lupus Erythematosus Lupus Erythematosus, Systemic, Type 16
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2	Catecholaminergic Polymorphic Ventricular Tachycardia 2 CPVT2 Vtsip Bidirectional Tachycardia Stress-Induced Polymorphic Ventricular Tachycardia Ventricular Tachycardia, Stress-Induced Polymorphic Cvpt2 Double Tachycardia Induced By Catecholamines Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Paroxysmal Ventricular Fibrillation Syncopal Paroxysmal Tachycardia Syncopal Tachyarythmia Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2 Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Multifocal Pvcs Multifocal Premature Ventricular Beats Paroxysmal Familial Ventricular Fibrillation
Spinocerebellar Ataxia 10	Spinocerebellar Ataxia Type 10 SCA10 Spinocerebellar Ataxia-10 Ataxia, Spinocerebellar, Type 10
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Autoimmune Lymphoproliferative Syndrome, Type Iii	ALPS3 Autoimmune Lymphoproliferative Syndrome Type 3 Cvid9 Immunodeficiency, Common Variable, 9, Formerly Cvid9, Formerly Autoimmune Lymphoproliferative Syndrome Type Iii Common Variable Immunodeficiency 9 Autoimmune Lymphoproliferative Syndrome 3 Immunodeficiency, Common Variable, 9 Type 3 Autoimmune Lymphoproliferative Syndrome Immunodeficiency, Variable, Common, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11122	PRKCD Human Pre-designed siRNA Set A		/	Unkown
HY-RS11123	Prkcd Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11124	Prkcd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKCD	VGNC	VGNC:33329
Canis familiaris	PRKCD	VGNC	VGNC:44979
Mus musculus	PRKCD	MGD	MGI:97598
Macaca mulatta	PRKCD	VGNC	VGNC:76411
Rattus norvegicus	PRKCD	RGD	RGD:67383
Felis catus	PRKCD	VGNC	VGNC:69058
Others	PRKCD	NCBI