2. Apoptosis
  3. RIP kinase Apoptosis
  4. RIPK1-IN-39

RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research.

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RIPK1-IN-39

RIPK1-IN-39 Chemical Structure

CAS No. : 3065634-42-3

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RIPK1-IN-39 Related Antibodies

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RIPK1 RIPK2 RIPK3

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Description

RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research[1].

IC50 & Target[1]

RIPK1

69.40 nM (IC50)

RIPK3

6946 nM (IC50)

Molecular Weight

525.60

Formula

C29H24FN5O2S
CAS No.
SMILES

O=C(C1CC1)NC2=NC3=C(S2)C=C(C4=CC=C5C(C(C(N[C@@H](C)C6=CC=C(F)C=C6)=O)=NC(C)=N5)=C4)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RIPK1-IN-39 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-393065634-42-3RIP kinaseApoptosisReceptor-interacting protein kinasesRIPKRIPK1-RIPK3-MLKL pathwayHT-22 cellsHT-29 cellsmiddle cerebral artery occlusionacute ischemic strokeInhibitorinhibitorinhibit

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