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RIPK1-IN-39

RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research.

For research use only. We do not sell to patients.

  • CAS No.: 3065634-42-3
  • Formula: C29H24FN5O2S
  • Molecular Weight:525.60
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • RIPK1-IN-39 Chemical Structure
    RIPK1-IN-39 Chemical Structure
CAS No.: 3065634-42-3
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All RIP kinase Isoforms

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100 mg

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  • RIPK1-IN-39 Chemical Structure
    RIPK1-IN-39 Chemical Structure
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  • RIPK1-IN-39