RIPK1-IN-23
RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM). RIPK1-IN-23 shows anti-inflammatory activities.
For research use only. We do not sell to patients.
- CAS No.: 3031534-16-1
- Formula: C27H22N6O3
- Molecular Weight:478.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RIPK1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | CC50 |
>100 μM
Compound: 19
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Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
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[PMID: 38309200] |
| HT-29 | EC50 |
1.7 nM
Compound: 19
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Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
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[PMID: 38309200] |
Chemical Information
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CAS No. 3031534-16-1
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Molecular Weight 478.50
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Formula C27H22N6O3
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SMILES
CN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RIPK1-IN-23 Related Classifications
HY-157963 Related Classifications
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