RIPK1-IN-23
RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM). RIPK1-IN-23 shows anti-inflammatory activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3031534-16-1
- 分子式: C27H22N6O3
- 分子量:478.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
RIPK1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | CC50 |
>100 μM
Compound: 19
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Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
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[PMID: 38309200] |
| HT-29 | EC50 |
1.7 nM
Compound: 19
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Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
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[PMID: 38309200] |
化学情報
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CAS 番号 3031534-16-1
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分子量 478.50
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分子式 C27H22N6O3
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SMILES
CN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RIPK1-IN-23 関連分類
HY-157963 関連分類
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