2. Immunology/Inflammation PROTAC
  3. Cyclic GMP-AMP Synthase PROTACs STING
  4. MS7829

MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits OTUB1 to cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research.

For research use only. We do not sell to patients.

MS7829

MS7829 Chemical Structure

CAS No. : 3060519-67-4

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MS7829 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits OTUB1 to cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research[1].

In Vitro

MS7829 (0-10 μM; 0-24 h) stabilizes cGAS and elevates downstream STING protein levels in HeLa cells in vitro in a concentration- and time-dependent manner, without affecting cGAS transcription[1].
MS7829 (5-10 μM; 24 h)-mediated cGAS stabilization and STING elevation in HeLa cells is dependent on specific binding to both cGAS and OTUB1[1].
MS7829 (5 μM; 24 h) activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in an OTUB1-dependent manner, increasing cGAMP production and downstream cytokine gene expression[1].
MS7829 (5 μM; days-2 weeks) potently suppresses HeLa cell proliferation and clonogenicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS7829 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa cells
Concentration: 5 μM
Incubation Time: 2 days (proliferation assay); 2 weeks (clonogenicity assay)
Result: Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.
Molecular Weight

910.95

Formula

C44H57Cl2N9O6S
CAS No.
SMILES

ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CC(NCCCCCCCCCNC(CCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS7829 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS78293060519-67-4MS 7829MS-7829Cyclic GMP-AMP SynthasePROTACsSTINGcGASStimulator of Interferon GenesTMEM173MITAERISMPYScGAMPHeLa cellsIRF3innate immune signalingcytokine gene expressioncell proliferationOTUB1clonogenicityInhibitorinhibitorinhibit

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