HSV-60mer sodium
Based on 1 Customer Validation
HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.11%
- Molecular Weight:36939.88
-
Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
HSV-60mer sodium (3 h) co-localizes with endogenous cytoplasmic IFI16 in PMA-treated THP-1 cells[1].
HSV-60mer sodium binds directly and cooperatively to the HINb and HINab domains of IFI16 in vitro, but does not bind to the HINa domain alone[1].
HSV-60mer sodium (6 h) requires IFI16 for its induced IFNβ mRNA induction in human monocytic THP-1 cells[1].
HSV-60mer sodium (6 h) requires IFNβ mRNA induction in murine macrophage RAW264.7 cells[1].
HSV-60mer sodium (18 h) requires IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium (2 μg/mL; 24 h) pre-treatment of murine macrophage RAW264.7 cells potently suppresses subsequent HSV-1 replication[1].
HSV-60mer sodium induces IFNβ independent of TLR (MyD88/TRIF) and Pol III pathways in murine macrophages and HEK293 cells[1].
HSV-60mer sodium (18 h) requires STING for its induced IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium directly binds to recombinant GST-tagged LSm14A protein in a cell-free GST pull-down assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 36939.88
-
Color White to off-white
-
SMILES
[HSV-60mer (sodium)]
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reinheit & Dokumentation
-
Data Sheet (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Unterholzner L, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11(11):997-1004. [Content Brief]
[2]. Li Y, et al. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109(29):11770-11775. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HSV-60mer sodium Related Classifications
HY-160222 Related Classifications
Powered by Bioz