2. Anti-infection Immunology/Inflammation NF-κB
  3. HSV STING IFNAR NF-κB
  4. HSV-60mer sodium

HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection.

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HSV-60mer sodium

HSV-60mer sodium Chemical Structure

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HSV-60mer sodium Related Antibodies

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Description

HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection[1][2].

In Vitro

HSV-60mer sodium (3 h) co-localizes with endogenous cytoplasmic IFI16 in PMA-treated THP-1 cells[1].
HSV-60mer sodium binds directly and cooperatively to the HINb and HINab domains of IFI16 in vitro, but does not bind to the HINa domain alone[1].
HSV-60mer sodium (6 h) requires IFI16 for its induced IFNβ mRNA induction in human monocytic THP-1 cells[1].
HSV-60mer sodium (6 h) requires IFNβ mRNA induction in murine macrophage RAW264.7 cells[1].
HSV-60mer sodium (18 h) requires IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium (2 μg/mL; 24 h) pre-treatment of murine macrophage RAW264.7 cells potently suppresses subsequent HSV-1 replication[1].
HSV-60mer sodium induces IFNβ independent of TLR (MyD88/TRIF) and Pol III pathways in murine macrophages and HEK293 cells[1].
HSV-60mer sodium (18 h) requires STING for its induced IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium directly binds to recombinant GST-tagged LSm14A protein in a cell-free GST pull-down assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSV-60mer sodium Related Antibodies
Molecular Weight

36939.88

Appearance

Solid

Color

White to off-white

SMILES

[HSV-60mer (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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HSV-60mer sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSV-60merHSVSTINGIFNARNF-κBHerpes simplex virusStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptor Nuclear factor-κBNuclear factor-kappaBHSV-1mouse embryonic fibroblastsTHP-1 cellsIFI16IRF3murine macrophagesLSm14ATBK1Inhibitorinhibitorinhibit

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