HSV-60mer sodium
Based on 1 Customer Validation
HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection.
For research use only. We do not sell to patients.
- Purity: 98.11%
- Molecular Weight:36939.88
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HSV-60mer sodium (3 h) co-localizes with endogenous cytoplasmic IFI16 in PMA-treated THP-1 cells[1].
HSV-60mer sodium binds directly and cooperatively to the HINb and HINab domains of IFI16 in vitro, but does not bind to the HINa domain alone[1].
HSV-60mer sodium (6 h) requires IFI16 for its induced IFNβ mRNA induction in human monocytic THP-1 cells[1].
HSV-60mer sodium (6 h) requires IFNβ mRNA induction in murine macrophage RAW264.7 cells[1].
HSV-60mer sodium (18 h) requires IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium (2 μg/mL; 24 h) pre-treatment of murine macrophage RAW264.7 cells potently suppresses subsequent HSV-1 replication[1].
HSV-60mer sodium induces IFNβ independent of TLR (MyD88/TRIF) and Pol III pathways in murine macrophages and HEK293 cells[1].
HSV-60mer sodium (18 h) requires STING for its induced IFNβ protein secretion from murine bone marrow-derived macrophages[1].
HSV-60mer sodium directly binds to recombinant GST-tagged LSm14A protein in a cell-free GST pull-down assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 36939.88
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Color White to off-white
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SMILES
[HSV-60mer (sodium)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Unterholzner L, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11(11):997-1004. [Content Brief]
[2]. Li Y, et al. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109(29):11770-11775. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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