RB1 - RB transcriptional corepressor 1 Gene

Also Known as RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5925

About RB1

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,303,751-48,481,890 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 169 phenotypes. Ubiquitous expression in lymph node (RPKM 18.0), thyroid (RPKM 16.4) and 25 other tissues.

Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood Cancer retinoblastoma (RB), bladder Cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

RB1 Products (5)

mRNA	Protein	Name
NM_000321.3	NP_000312.2	retinoblastoma-associated protein isoform 1
NM_001407165.1	NP_001394094.1	retinoblastoma-associated protein isoform 2
NM_001407166.1	NP_001394095.1	retinoblastoma-associated protein isoform 3
NM_001407167.1	NP_001394096.1	retinoblastoma-associated protein isoform 4
NM_001407168.1	NP_001394097.1	retinoblastoma-associated protein isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19223331	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	8245034	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8288605	GOA
enables importin-alpha family protein binding	IPI IPI: Inferred from physical interaction	12695505	GOA
enables kinase binding	IDA IDA: Inferred from direct assay	16286473	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	16360038	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	16360038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1331501	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	10944455	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Ras protein signal transduction	IEP IEP: Inferred from expression pattern	9054499	GOA
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	20551165	GOA
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	17540172	GOA
involved in maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	20551165	GOA
involved in myoblast differentiation	IMP IMP: Inferred from mutant phenotype	15541338	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10783144	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17540172	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25100735	GOA
involved in negative regulation of protein kinase activity	IPI IPI: Inferred from physical interaction	9858607	GOA
involved in positive regulation of mitotic metaphase/anaphase transition	IMP IMP: Inferred from mutant phenotype	20551165	GOA
acts upstream of or within positive regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	25100735	GOA
involved in protein localization to chromosome, centromeric region	IMP IMP: Inferred from mutant phenotype	20551165	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1531329	GOA
involved in regulation of lipid kinase activity	IDA IDA: Inferred from direct assay	16286473	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20551165	GOA
involved in sister chromatid biorientation	IMP IMP: Inferred from mutant phenotype	20551165	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	9448006	GOA
part of Rb-E2F complex	IDA IDA: Inferred from direct assay	8245034	GOA
part of Rb-E2F complex	IPI IPI: Inferred from physical interaction	16360038	GOA
part of chromatin lock complex	IPI IPI: Inferred from physical interaction	17540172	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	12037672	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	8245034	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1531329	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RB1 Protein Structure

DUF3452

RB_A

RB_B

Rb_C

0
200
400
600
800
928 a.a.

Protein Preferred Names	Protein Names
retinoblastoma-associated protein	prepro-retinoblastoma-associated protein

RB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RB1	P06400	PURA	Homo sapiens	Q00577	Anti Bait CoIP	7592647
Intra	RB1	P06400	PURA	Homo sapiens	Q00577	Pull Down	7592647
Intra	RB1	P06400	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	23602568
Intra	RB1	P06400	NEFM	Homo sapiens	P07197	Display Tech	20195357
Intra	RB1	P06400	CHEK2	Homo sapiens	O96017	Anti Bait CoIP	17380128
Cross	RB1	P06400	Smarca4	Mus musculus	Q3TKT4	Pull Down	7923370
Intra	RB1	P06400	SETD7	Homo sapiens	Q8WTS6	Methyltransferase Ass	21119616
Intra	RB1	P06400	E2F5	Homo sapiens	Q15329	ITC	12502741
Intra	RB1	P06400	E2F5	Homo sapiens	Q15329	Pull Down	16360038
Intra	RB1	P06400	KDM5A	Homo sapiens	P29375	Anti Bait CoIP	22615382
Intra	RB1	P06400	FOXO3	Homo sapiens	O43524	Pull Down	25609649
Cross	RB1	P06400	E7	Human papillomavirus	P06788	SLC	22898364
Cross	RB1	P06400	E7	Human papillomavirus	P06788	Competition Binding	20088881
Cross	RB1	P06400	Sirt1	Mus musculus	Q923E4	Deacetylase Assay	17620057
Cross	RB1	P06400	Cenpf	Mus musculus	Q155P7	Pull Down	14555653
Cross	RB1	P06400	P0C6X7-PRO_0000037321	Human SARS coronavirus	P0C6X7-PRO_0000037321	Pull Down	22301153
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Pull Down	10228159
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Pull Down	9468140
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	16766265
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	9468140
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Pull Down	9468139
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	CoIP	10779361
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	9468139
Intra	RB1	P06400	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	22615382
Intra	RB1	P06400	USP7	Homo sapiens	Q93009	Anti Bait CoIP	24823443
Intra	RB1	P06400	PPP1CA	Homo sapiens	P62136	CoIP	8384581
Intra	RB1	P06400	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	12434308
Intra	RB1	P06400	PPP1CA	Homo sapiens	P62136	Y2H	8384581
Intra	RB1	P06400	RAF1	Homo sapiens	P04049	Anti Bait CoIP	21139044
Intra	RB1	P06400	CDK2	Homo sapiens	P24941	Protein Kinase Assay	8756624
Intra	RB1	P06400	CDK2	Homo sapiens	P24941	Protein Kinase Assay	20871633
Intra	RB1	P06400	MDM2	Homo sapiens	Q00987	Pull Down	7791904
Intra	RB1	P06400	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	20871633
Intra	RB1	P06400	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20871633
Intra	RB1	P06400	CCNC	Homo sapiens	P24863	Anti Bait CoIP	15084261
Intra	RB1	P06400	MDM4	Homo sapiens	O15151	Anti Tag CoIP	16510145
Intra	RB1	P06400	GRB2	Homo sapiens	P62993	Y2H Array	25814554
Intra	RB1	P06400	E2F1	Homo sapiens	Q01094	Pull Down	11713253
Intra	RB1	P06400	E2F1	Homo sapiens	Q01094	Pull Down	16360038
Intra	RB1	P06400	E2F1	Homo sapiens	Q01094	Pull Down	16249186
Intra	RB1	P06400	E2F4	Homo sapiens	Q16254	Anti Tag CoIP	34591642
Intra	RB1	P06400	E2F4	Homo sapiens	Q16254	Pull Down	16360038
Intra	RB1	P06400	E2F4	Homo sapiens	Q16254	Anti Tag CoIP	34591612
Cross	RB1	P06400	lt_sv40	Simian virus 40	P03070	Pull Down	8551580
Cross	RB1	P06400	lt_sv40	Simian virus 40	P03070	Y2H	9697699
Intra	RB1	P06400	DYRK1B	Homo sapiens	Q9Y463	BiFC	23602568
Cross	RB1	P06400	ospF	Shigella flexneri	Q8VSP9	Pull Down	19017275
Cross	RB1	P06400	E7	Human papillomavirus	P06464	CoIP	2153075
Cross	RB1	P06400	E7	Human papillomavirus	P06464	CoIP	16061792
Cross	RB1	P06400	E7	Human papillomavirus	A0MPS7	CoIP	1331501
Intra	RB1	P06400	DGKZ	Homo sapiens	Q13574-2	Pull Down	16286473
Intra	RB1	P06400	DGKZ	Homo sapiens	Q13574-2	CoIP	16286473
Intra	RB1	P06400	E2F2	Homo sapiens	Q14209	Anti Bait CoIP	17380128
Intra	RB1	P06400	E2F2	Homo sapiens	Q14209	Anti Tag CoIP	17380128
Intra	RB1	P06400	E2F2	Homo sapiens	Q14209	ITC	12502741
Intra	RB1	P06400	E2F2	Homo sapiens	Q14209	Pull Down	16360038
Intra	RB1	P06400	MAPK14	Homo sapiens	Q16539	Protein Kinase Assay	20871633
Intra	RB1	P06400	MAPK14	Homo sapiens	Q16539	Protein Kinase Assay	17380128
Intra	RB1	P06400	RNF40	Homo sapiens	O75150	Anti Tag CoIP	10944455
Intra	RB1	P06400	RNF40	Homo sapiens	O75150	Y2H	10944455
Intra	RB1	P06400	RBBP8	Homo sapiens	Q99708	CoIP	10779361
Intra	RB1	P06400	E2F3	Homo sapiens	O00716	Anti Tag CoIP	34591612
Intra	RB1	P06400	E2F3	Homo sapiens	O00716	Anti Bait CoIP	19249677
Intra	RB1	P06400	E2F3	Homo sapiens	O00716	Anti Bait CoIP	17380128
Intra	RB1	P06400	E2F3	Homo sapiens	O00716	CoIP	10779361
Intra	RB1	P06400	PRMT2	Homo sapiens	P55345	Pull Down	16616919
Intra	RB1	P06400	NCOA6	Homo sapiens	Q14686	Y2H	14645241
Intra	RB1	P06400	NCOA6	Homo sapiens	Q14686	Pull Down	14645241
Intra	RB1	P06400	NCOA6	Homo sapiens	Q14686	Anti Bait CoIP	14645241
Cross	RB1	P06400	Psmd10	Mus musculus	Q9Z2X2	Pull Down	17292836
Cross	RB1	P06400	Cdk4	Mus musculus	P30285	Protein Kinase Assay	17045206
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Pull Down	10779361
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Competition Binding	20088881
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Y2H	12813456
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Fluorescence	20088881
Cross	RB1	P06400	E7	Human papillomavirus	P03129	CoIP	2153075
Cross	RB1	P06400	E7	Human papillomavirus	P03129	Comig Non-Denat Gel	20088881
Cross	RB1	P06400	E7	Human papillomavirus	P03129	CoIP	16061792
Cross	RB1	P06400	Hmga2	Mus musculus	P52927	Far-WB	16766265
Cross	RB1	P06400	Hmga2	Mus musculus	P52927	Pull Down	16766265
Cross	RB1	P06400	Hmga2	Mus musculus	P52927	Anti Tag CoIP	16766265
Intra	RB1	P06400	PA2G4	Homo sapiens	Q9UQ80	Pull Down	11268000
Intra	RB1	P06400	HBP1	Homo sapiens	O60381	Anti Bait CoIP	23859194
Cross	RB1	P06400	E7	Human papillomavirus	P06465	SLC	22898364
Cross	RB1	P06400	E7	Human papillomavirus	P06465	Pull Down	16249186
Intra	RB1	P06400	CHEK1	Homo sapiens	O14757	Pull Down	17380128
Intra	RB1	P06400	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	17380128
Cross	RB1	P06400	Q86500-PRO_0000041225	Rubella virus	Q86500-PRO_0000041225	Pull Down	9608663
Cross	RB1	P06400	e1a_ade05	Human adenovirus C	P03255	Anti Bait CoIP	12743606
Cross	RB1	P06400	e1a_ade05	Human adenovirus C	P03255	Anti Bait CoIP	19249677
Cross	RB1	P06400	e1a_ade05	Human adenovirus C	P03255	Competition Binding	1331501
Cross	RB1	P06400	e1a_ade05	Human adenovirus C	P03255	Pull Down	1331501
Cross	RB1	P06400	e1a_ade05	Human adenovirus C	P03255	CoIP	2162480
Cross	RB1	P06400	p03255-2	Human adenovirus C	P03255-2	Anti Bait CoIP	9881977
Cross	RB1	P06400	p03255-2	Human adenovirus C	P03255-2	Anti Bait CoIP	12743606

Cross: Cross-species interaction Intra: Intraspecies interaction

RB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80300	Rb Antibody (YA104)	WB, IHC-P, ICC/IF, IP, IF-Tissue	Human, Mouse
HY-P80300A	Rb Antibody (YA104) (PBS only)	WB, IHC-P, ICC/IF, IP, IF-Tissue	Human, Mouse
HY-P80476	Phospho-Rb (Ser807) Antibody (YA159)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P81301	Phospho-Rb (Thr356) Antibody (YA1029)	WB, IHC-P, IP	Human
HY-P81301A	Phospho-Rb (Ser780) Antibody (YA1030)	WB, IP	Human, Mouse
HY-P81301AA	Phospho-Rb (Ser780) Antibody (YA1030)(PBS only)	WB, IP	Human, Mouse
HY-P81301B	Phospho-Rb (Ser811) Antibody (YA1031)	WB	Human, Hamster
HY-P81301BA	Phospho-Rb (Ser811) Antibody (YA1031)(PBS only)	WB	Human, Hamster
HY-P81301C	Phospho-Rb (Ser608) Antibody (YA1032)	WB, IHC-P	Human
HY-P81301CA	Phospho-Rb (Ser608) Antibody (YA1032)(PBS only)	WB, IHC-P	Human, Rat
HY-P81301D	Phospho-Rb (Thr252) Antibody (YA1033)	WB, IHC-P	Human
HY-P81301DA	Phospho-Rb (Thr252) Antibody (YA1033)(PBS only)	WB, IHC-P	Human, Rat
HY-P85348	Rb Antibody (YA5040)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human
HY-P85348A	Rb Antibody (YA5040) (PBS only)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Lung Oat Cell Carcinoma	Oat Cell Carcinoma Carcinoma Oat Cell Carcinoma, Small Cell
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Colorectal Cancer, Hereditary Nonpolyposis, Type 4	HNPCC4 Hereditary Nonpolyposis Colorectal Cancer Type 4 Hereditary Non-Polyposis Colorectal Cancer 4 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Pituitary Tumors	Pituitary Tumor Pituitary Neoplasms
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Papilloma	Papillomatosis
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Liposarcoma	Lipomatous Cancer
Urinary Bladder Inverted Papilloma	Inverted Papilloma Of Urinary Bladder
Bilateral Retinoblastoma
Unilateral Retinoblastoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Suppressor Of Tumorigenicity 3	Cervical Carcinoma ST3 Tumor-Suppressor Gene, Hela Cell Type Tshl Cervical Carcinoma, Tumor-Suppressor Gene Involved In Ccts Cervix Carcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Tongue Carcinoma	Tongue Cancer Malignant Neoplasm Of Tongue Tongue Neoplasms Tongue Neoplasm
Gallbladder Adenoma
Inverted Papilloma	Inverted Papilloma, Squamous Cell Papilloma Inverted Papilloma, Inverted Inverted Squamous Cell Papilloma
Leiomyosarcoma	Leiomyosarcomas
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Leukocoria	Leucocoria
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Intraocular Retinoblastoma	Pediatric Intraocular Retinoblastoma
Rhabdomyosarcoma
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Anaplastic Astrocytoma	Grade Iii Astrocytoma Astrocytoma, Anaplastic Grade Iii Astrocytic Tumor
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Uterine Corpus Endometrial Carcinoma
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Oesophagostomiasis	Infection By Oesophagostomum Oesophagostomosis
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Anus Cancer	Anal Cancer Anal Carcinoma Malignant Anal Tumor Cancer Of The Anus Malignant Neoplasm Of Anus Anus Neoplasms
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Uterus Carcinoma In Situ
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cervix Uteri Carcinoma In Situ	Carcinoma In Situ Of Cervix Carcinoma In Situ Of Uterine Cervix Cervical Intraepithelial Neoplasia Carcinoma Of Cervix Stage 0 Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia Cervix Ca In Situ Cin Iii Cin Iii - Carcinoma In Situ Of Cervix Cin Iii - Severe Dyskaryosis Severe Dysplasia Of Cervix Severe Dysplasia Of The Cervix Uteri Squamous Intraepithelial Neoplasia, Grade Iii Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Sarcomatoid Transitional Cell Carcinoma	Transitional Cell Carcinoma, Sarcomatoid Transitional Spindle Cell Carcinoma Transitional Cell Carcinoma, Spindle Cell
Sensory System Disease
Vallecula Cancer	Malignant Tumor Of Vallecula
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-183118	CID-078		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0039	Ginsenoside Rb1		99.75%	Unkown
HY-N0904	Ginsenoside C-K	Inhibitor	99.93%	Unkown
HY-124962	D-NMAPPD		99.74%	Unkown
HY-159805	CDK2-IN-31	Inhibitor	98.22%	Unkown
HY-N7678	Gypenoside LXXV		99.79%	Unkown
HY-RS11713	RB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0039R	Ginsenoside Rb1 (Standard)		99.26%	Unkown
HY-D3376	6-Carboxy-H2DCFDA		/	Unkown
HY-N0904R	Ginsenoside C-K (Standard)	Inhibitor	/	Unkown
HY-N18026	Ginsenoside V		/	Unkown
HY-N18029	(24S)-Ginsenoside V		/	Unkown
HY-N18215	Ginsenoside mRb2		/	Unkown
HY-N18382	5,6-Didehydroginsenoside Rb1		/	Unkown
HY-N18670	Panax notoginseng extract		/	Unkown
HY-RS06683	IL12RB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11714	RB1CC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11754	RBM45 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174616	Human IL23R mRNA		/	Unkown
HY-174640	Human IL12RB1 mRNA		/	Unkown
HY-176853	Myt1-IN-6	Inhibitor	/	Unkown
HY-N8030	Pseudoginsenoside Rg3		/	Unkown
HY-RS16852	Rb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23293	Rb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990776	Vimekofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RB1	VGNC	VGNC:33768
Mus musculus	RB1	MGD	MGI:97874
Rattus norvegicus	RB1	RGD	RGD:3540
Macaca mulatta	RB1	VGNC	VGNC:76675
Felis catus	RB1	VGNC	VGNC:69254
Canis familiaris	RB1	VGNC	VGNC:45389
Others	RB1	NCBI