E2F4 - E2F transcription factor 4 Gene

Also Known as E2F-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1874

About E2F4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,192,155-67,198,918 (from NCBI)

This gene has 13 transcripts (splice variants), 253 orthologues and 7 paralogues. Ubiquitous expression in bone marrow (RPKM 45.6), placenta (RPKM 31.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human Cancer. [provided by RefSeq, Jul 2008]

E2F4 Products (1)

mRNA	Protein	Name
NM_001950.4	NP_001941.2	transcription factor E2F4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11418595	GOA
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	17062573	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11418595	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11418595	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10488129	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25100735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11418595	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16360038	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11418595	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	21454377	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17062573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F4 Protein Structure

E2F_TDP

0
100
200
300
413 a.a.

Protein Preferred Names	Protein Names
transcription factor E2F4	E2F transcription factor 4, p107/p130-binding

E2F4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	E2F4	Q16254	LIN9	Homo sapiens	Q5TKA1	Anti Bait CoIP	17159899
Intra	E2F4	Q16254	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	E2F4	Q16254	RB1	Homo sapiens	P06400	ITC	16360038
Intra	E2F4	Q16254	TFDP1	Homo sapiens	Q14186	ITC	16360038
Cross	E2F4	Q16254	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
Intra	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	22002537
Intra	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	20133863

Cross: Cross-species interaction Intra: Intraspecies interaction

E2F4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82983	E2F4 Antibody (YA2728)	WB, IHC-P	Human
HY-P82983A	E2F4 Antibody (YA2728)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Epilepsy, Idiopathic Generalized 3	EIG3 Idiopathic Generalized Epilepsy 3 Epilepsy, Idiopathic Generalized, Susceptibility To, 3 Epilepsy, Idiopathic Generalized Locus On Chromosome 9 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 9 Epilepsy, Idiopathic Generalized, Susceptibility To 3
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Alstrom Syndrome	ALMS Alström Syndrome Alss Alstrom-Hallgren Syndrome Alstroem Syndrome
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Ocular Cancer	Eye Neoplasm Eye Carcinoma Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Soft Palate Cancer	Malignant Tumor Of Soft Palate Malignant Tumor Of The Soft Palate Palate Cancer Soft Palate
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16667	HLM006474	Inhibitor	98.44%	Unkown
HY-RS04113	E2F4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18033	E2f4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24507	E2f4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	E2F4	MGD	MGI:103012
Rattus norvegicus	E2F4	RGD	RGD:2322129
Macaca mulatta	E2F4	VGNC	VGNC:72025
Felis catus	E2F4	VGNC	VGNC:61696
Bos taurus	E2F4	VGNC	VGNC:28288
Canis familiaris	E2F4	VGNC	VGNC:40166
Others	E2F4	NCBI