LIN9 - lin-9 DREAM MuvB core complex component Gene

Also Known as TGS; BARA; TGS1; TGS2; Lin-9; BARPsv

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 286826

About LIN9

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,231,149-226,309,767 (from NCBI)

This gene has 6 transcripts (splice variants) and 220 orthologues. Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues.

Summary

This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of Other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

LIN9 Products (9)

mRNA Protein Name
NM_001270409.1 NP_001257338.1 protein lin-9 homolog isoform 2
NM_001270410.2 NP_001257339.1 protein lin-9 homolog isoform 3
NM_001366237.1 NP_001353166.1 protein lin-9 homolog isoform 4
NM_001366238.1 NP_001353167.1 protein lin-9 homolog isoform 5
NM_001366239.1 NP_001353168.1 protein lin-9 homolog isoform 6
NM_001366240.1 NP_001353169.1 protein lin-9 homolog isoform 7
NM_001366241.1 NP_001353170.1 protein lin-9 homolog isoform 3
NM_001366245.2 NP_001353174.1 protein lin-9 homolog isoform 8
NM_173083.3 NP_775106.2 protein lin-9 homolog isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17159899 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN9 Protein Structure

DIRP

DIRP: DIRP (143 - 247)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 558 a.a.
Protein Preferred Names Protein Names

protein lin-9 homolog

  • TUDOR gene similar protein

LIN9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIN9 Q5TKA1 MYBL2 Homo sapiens P10244
Anti Bait CoIP
17531812
Intra
LIN9 Q5TKA1 MYBL2 Homo sapiens P10244
Anti Bait CoIP
17159899
Intra
LIN9 Q5TKA1 MYBL2 Homo sapiens P10244
Anti Tag CoIP
33961781
Intra
LIN9 Q5TKA1 E2F4 Homo sapiens Q16254
Anti Tag CoIP
33961781
Intra
LIN9 Q5TKA1 E2F4 Homo sapiens Q16254
Anti Bait CoIP
17531812
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Distal Muscular Dystrophy With Anterior Tibial Onset

  • Dmat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168083 Dot1L-IN-9 Inhibitor / Unkown
HY-RS07679 LIN9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LIN9 VGNC VGNC:30898
Canis familiaris LIN9 VGNC VGNC:42687
Macaca mulatta LIN9 VGNC VGNC:74166
Mus musculus LIN9 MGD MGI:1919818
Rattus norvegicus LIN9 RGD RGD:1591104
Felis catus LIN9 VGNC VGNC:63235
Others LIN9 NCBI