MYBL2 - MYB proto-oncogene like 2 Gene

Also Known as BMYB; B-MYB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4605

About MYBL2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,667,114-43,716,482 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 6 paralogues. Biased expression in bone marrow (RPKM 29.8), lymph node (RPKM 25.5) and 11 other tissues.

Summary

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

MYBL2 Products (2)

mRNA Protein Name
NM_001278610.2 NP_001265539.1 myb-related protein B isoform 2
NM_002466.4 NP_002457.1 myb-related protein B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10770937 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10770937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17159899 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10770937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYBL2 Protein Structure

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (34 - 94)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (136 - 178)

Cmyb_C

Cmyb_C: C-myb, C-terminal (451 - 605)

  • 0
  • 200
  • 400
  • 600
  • 700 a.a.
Protein Preferred Names Protein Names

myb-related protein B

  • myb-like protein 2

MYBL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYBL2 P10244 LIN9 Homo sapiens Q5TKA1
Anti Tag CoIP
17159899
Cross: Cross-species interaction Intra: Intraspecies interaction

MYBL2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810165 B-Myb Antibody (YA9509) WB, ICC/IF, IF-Tissue, IP human
HY-P811105 MYBL2 Antibody WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Paraneoplastic Cerebellar Degeneration

  • Pcd

  • Paraneoplastic Cerebellar Ataxia

  • Rapidely Progressive Cerebellar Syndrome

  • Subacute Cerebellar Degeneration
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Advanced Sleep Phase Syndrome, Familial, 3

  • Advanced Sleep Phase Syndrome 3

  • FASPS3

  • Familial Advanced Sleep Phase Syndrome 3

  • Sleep Phase Syndrome, Advanced, Familial, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08872 MYBL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20059 Mybl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26563 Mybl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYBL2 VGNC VGNC:68372
Rattus norvegicus MYBL2 RGD RGD:1308474
Bos taurus MYBL2 VGNC VGNC:31779
Mus musculus MYBL2 MGD MGI:101785
Macaca mulatta MYBL2 VGNC VGNC:75092
Canis familiaris MYBL2 VGNC VGNC:43521
Others MYBL2 NCBI