PRMT2 - protein arginine methyltransferase 2 Gene

Also Known as HRMT1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3275

About PRMT2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,635,674-46,665,124 (from NCBI)

This gene has 15 transcripts (splice variants), 159 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 11.6), spleen (RPKM 8.9) and 25 other tissues.

Summary

Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of Androgen Receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRMT2 Products (8)

mRNA Protein Name
NM_001242864.3 NP_001229793.1 protein arginine N-methyltransferase 2 isoform 2
NM_001242865.3 NP_001229794.1 protein arginine N-methyltransferase 2 isoform 3
NM_001242866.3 NP_001229795.1 protein arginine N-methyltransferase 2 isoform 4
NM_001286676.2 NP_001273605.1 protein arginine N-methyltransferase 2 isoform 5
NM_001286677.2 NP_001273606.1 protein arginine N-methyltransferase 2 isoform 6
NM_001286678.2 NP_001273607.1 protein arginine N-methyltransferase 2 isoform 7
NM_001535.5 NP_001526.2 protein arginine N-methyltransferase 2 isoform 1
NM_206962.4 NP_996845.1 protein arginine N-methyltransferase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
19405910 GOA
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
17587566 GOA
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
17587566 GOA
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
12039952 GOA
enables nuclear progesterone receptor binding IPI
IPI: Inferred from physical interaction
12039952 GOA
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
12039952 GOA
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
12039952 GOA
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
12039952 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11513728 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12039952 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12039952 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16648481 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16648481 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12039952 GOA
involved in positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16648481 GOA
involved in regulation of androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
17587566 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11513728 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17587566 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11513728 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT2 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (37 - 84)

PRMT5

PRMT5: PRMT5 arginine-N-methyltransferase (133 - 397)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 2

  • HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1

PRMT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRMT2 P55345 SHANK3 Homo sapiens Q9BYB0
Y2H Pooling
21653829
Intra
PRMT2 P55345 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
33961781
Intra
PRMT2 P55345 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
28514442
Intra
PRMT2 P55345 RBM12 Homo sapiens Q9NTZ6
Validated Y2H
26871637
Intra
PRMT2 P55345 RBM12 Homo sapiens Q9NTZ6
Y2H Prey Pooling
26871637
Intra
PRMT2 P55345 RBM12 Homo sapiens Q9NTZ6
Y2H Array
26871637
Intra
PRMT2 P55345 HTT Homo sapiens P42858
Anti Tag CoIP
28514442
Intra
PRMT2 P55345 HTT Homo sapiens P42858
Y2H
17500595
Intra
PRMT2 P55345 HTT Homo sapiens P42858
Anti Tag CoIP
33961781
Intra
PRMT2 P55345 RB1 Homo sapiens P06400
Anti Bait CoIP
16616919
Intra
PRMT2 P55345 CBLB Homo sapiens Q13191
Y2H Prey Pooling
26871637
Intra
PRMT2 P55345 CBLB Homo sapiens Q13191
Validated Y2H
26871637
Intra
PRMT2 P55345 CBLB Homo sapiens Q13191
Y2H Array
26871637
Intra
PRMT2 P55345 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11170 PRMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19732 Prmt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26228 Prmt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRMT2 MGD MGI:1316652
Bos taurus PRMT2 VGNC VGNC:33348
Felis catus PRMT2 VGNC VGNC:67651
Rattus norvegicus PRMT2 RGD RGD:1565519
Canis familiaris PRMT2 VGNC VGNC:44996
Macaca mulatta PRMT2 VGNC VGNC:76359
Others PRMT2 NCBI