2. Gene
  3. CBLB - Cbl proto-oncogene B Gene

CBLB - Cbl proto-oncogene B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Cbl-b; RNF56; Nbla00127

Gene ID: 868 | Gene type: protein coding

About CBLB

Cytogenetic location: 3q13.11 Genomic coordinates (GRCh38): 3:105,655,461-105,869,449 (from NCBI)

This gene has 17 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating Enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in Antifungal host defense and that its inhibition leads to increased Fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including Cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]

CBLB Products(21)

mRNA Protein Name
NM_001321786.1 NP_001308715.1 E3 ubiquitin-protein ligase CBL-B isoform a
NM_001321788.2 NP_001308717.1 E3 ubiquitin-protein ligase CBL-B isoform b
NM_001321789.1 NP_001308718.1 E3 ubiquitin-protein ligase CBL-B isoform c
NM_001321790.2 NP_001308719.1 E3 ubiquitin-protein ligase CBL-B isoform d
NM_001321791.2 NP_001308720.1 E3 ubiquitin-protein ligase CBL-B isoform e
NM_001321793.2 NP_001308722.1 E3 ubiquitin-protein ligase CBL-B isoform e
NM_001321794.2 NP_001308723.1 E3 ubiquitin-protein ligase CBL-B isoform f
NM_001321795.2 NP_001308724.1 E3 ubiquitin-protein ligase CBL-B isoform f
NM_001321796.2 NP_001308725.1 E3 ubiquitin-protein ligase CBL-B isoform g
NM_001321797.2 NP_001308726.1 E3 ubiquitin-protein ligase CBL-B isoform h
NM_001321798.2 NP_001308727.1 E3 ubiquitin-protein ligase CBL-B isoform h
NM_001321799.2 NP_001308728.1 E3 ubiquitin-protein ligase CBL-B isoform i
NM_001321806.2 NP_001308735.1 E3 ubiquitin-protein ligase CBL-B isoform j
NM_001321807.2 NP_001308736.1 E3 ubiquitin-protein ligase CBL-B isoform j
NM_001321808.2 NP_001308737.1 E3 ubiquitin-protein ligase CBL-B isoform k
NM_001321811.2 NP_001308740.1 E3 ubiquitin-protein ligase CBL-B isoform l
NM_001321813.1 NP_001308742.1 E3 ubiquitin-protein ligase CBL-B isoform l
NM_001321816.2 NP_001308745.1 E3 ubiquitin-protein ligase CBL-B isoform m
NM_001321820.2 NP_001308749.1 E3 ubiquitin-protein ligase CBL-B isoform n
NM_001321822.2 NP_001308751.1 E3 ubiquitin-protein ligase CBL-B isoform o
NM_170662.5 NP_733762.2 E3 ubiquitin-protein ligase CBL-B isoform b

CBLB Protein Structure

Cbl_N

Cbl_N: CBL proto-oncogene N-terminal domain 1 (39 - 168)

Cbl_N2

Cbl_N2: CBL proto-oncogene N-terminus, EF hand-like domain (171 - 254)

Cbl_N3

Cbl_N3: CBL proto-oncogene N-terminus, SH2-like domain (256 - 341)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (372 - 416)

UBA

UBA: UBA/TS-N domain (934 - 964)

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  • 982 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL-B

Cas-Br-M (murine) ecotropic retroviral transforming sequence b

Recombinant CBLB Proteins

Cat. No. Product Name Accession Purity
HY-P78728 CBLB/RNF56 Protein, Human (HEK293, His) Q13191 (A39-F426) ≥95%
HY-P78921 CBLB/RNF56 Protein, Human (Biotinylated, HEK293, His-Avi) Q13191 (A39-F426) ≥95%

Related Diseases

Diseases Alias
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136339 Cbl-b-IN-1 Inhibitor 99.68% Unkown
HY-141432 NX-1607 Inhibitor 99.42% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.61% Unkown
HY-155477 Cbl-b-IN-15 Inhibitor / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156765 Cbl-b-IN-9 Inhibitor / Unkown
HY-156766 Cbl-b-IN-10 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-156769 Cbl-b-IN-13 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-RS01997 CBLB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CBLB VGNC VGNC:60421
Macaca mulatta CBLB VGNC VGNC:70555
Bos taurus CBLB VGNC VGNC:26809
Mus musculus CBLB MGD MGI:2146430
Rattus norvegicus CBLB RGD RGD:620535
Canis familiaris CBLB VGNC VGNC:38759