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CBLB - Cbl proto-oncogene B Gene

Also Known as Cbl-b; RNF56; Nbla00127

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 868

About CBLB

Cytogenetic location: 3q13.11 Genomic coordinates (GRCh38): 3:105,655,461-105,869,449 (from NCBI)

This gene has 17 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in Antifungal host defense and that its inhibition leads to increased Fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including Cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]

CBLB Products (21)

mRNA	Protein	Name
NM_001321786.1	NP_001308715.1	E3 ubiquitin-protein ligase CBL-B isoform a
NM_001321788.2	NP_001308717.1	E3 ubiquitin-protein ligase CBL-B isoform b
NM_001321789.1	NP_001308718.1	E3 ubiquitin-protein ligase CBL-B isoform c
NM_001321790.2	NP_001308719.1	E3 ubiquitin-protein ligase CBL-B isoform d
NM_001321791.2	NP_001308720.1	E3 ubiquitin-protein ligase CBL-B isoform e
NM_001321793.2	NP_001308722.1	E3 ubiquitin-protein ligase CBL-B isoform e
NM_001321794.2	NP_001308723.1	E3 ubiquitin-protein ligase CBL-B isoform f
NM_001321795.2	NP_001308724.1	E3 ubiquitin-protein ligase CBL-B isoform f
NM_001321796.2	NP_001308725.1	E3 ubiquitin-protein ligase CBL-B isoform g
NM_001321797.2	NP_001308726.1	E3 ubiquitin-protein ligase CBL-B isoform h
NM_001321798.2	NP_001308727.1	E3 ubiquitin-protein ligase CBL-B isoform h
NM_001321799.2	NP_001308728.1	E3 ubiquitin-protein ligase CBL-B isoform i
NM_001321806.2	NP_001308735.1	E3 ubiquitin-protein ligase CBL-B isoform j
NM_001321807.2	NP_001308736.1	E3 ubiquitin-protein ligase CBL-B isoform j
NM_001321808.2	NP_001308737.1	E3 ubiquitin-protein ligase CBL-B isoform k
NM_001321811.2	NP_001308740.1	E3 ubiquitin-protein ligase CBL-B isoform l
NM_001321813.1	NP_001308742.1	E3 ubiquitin-protein ligase CBL-B isoform l
NM_001321816.2	NP_001308745.1	E3 ubiquitin-protein ligase CBL-B isoform m
NM_001321820.2	NP_001308749.1	E3 ubiquitin-protein ligase CBL-B isoform n
NM_001321822.2	NP_001308751.1	E3 ubiquitin-protein ligase CBL-B isoform o
NM_170662.5	NP_733762.2	E3 ubiquitin-protein ligase CBL-B isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10022120	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBLB Protein Structure

Cbl_N

Cbl_N2

Cbl_N3

zf-C3HC4_3

UBA

0
200
400
600
800
982 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase CBL-B	Cas-Br-M (murine) ecotropic retroviral transforming sequence b

CBLB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CBLB	Q13191	NF2	Homo sapiens	P35240-4	Y2H Array	32814053
Intra	CBLB	Q13191	NF2	Homo sapiens	P35240-4	Y2H Pooling	32814053
Intra	CBLB	Q13191	NF2	Homo sapiens	P35240-4	Validated Y2H	32814053
Intra	CBLB	Q13191	DNAJB6	Homo sapiens	O75190	Y2H Array	32814053
Intra	CBLB	Q13191	DNAJB6	Homo sapiens	O75190	Validated Y2H	32814053
Intra	CBLB	Q13191	DNAJB6	Homo sapiens	O75190	Y2H Pooling	32814053
Intra	CBLB	Q13191	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	CBLB	Q13191	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	CBLB	Q13191	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	CBLB	Q13191	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	25416956
Intra	CBLB	Q13191	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	CBLB	Q13191	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	25416956
Intra	CBLB	Q13191	UBASH3B	Homo sapiens	Q8TF42	Y2H Prey Pooling	25416956
Intra	CBLB	Q13191	PTK6	Homo sapiens	Q13882	Validated Y2H	32296183
Intra	CBLB	Q13191	VAV3	Homo sapiens	Q9UKW4	Validated Y2H	32296183
Intra	CBLB	Q13191	CD2AP	Homo sapiens	Q9Y5K6	NMR	23663663
Intra	CBLB	Q13191	CD2AP	Homo sapiens	Q9Y5K6	X-Ray Diffraction	17020880
Intra	CBLB	Q13191	CD2AP	Homo sapiens	Q9Y5K6	Pull Down	17020880
Intra	CBLB	Q13191	CD2AP	Homo sapiens	Q9Y5K6	Anti Bait CoIP	17020880
Intra	CBLB	Q13191	CD2AP	Homo sapiens	Q9Y5K6	ITC	23663663
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	NMR	19268472
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	Y2H	12177062
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	SAXS	23663663
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	ELISA	12829691
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	12177062
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	ITC	19268472
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	Validated Y2H	32296183
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	12177062
Intra	CBLB	Q13191	SH3KBP1	Homo sapiens	Q96B97	ITC	23663663
Intra	CBLB	Q13191	ASAP1	Homo sapiens	Q9ULH1	Pull Down	17255943
Intra	CBLB	Q13191	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	CBLB	Q13191	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	CBLB	Q13191	NCK1	Homo sapiens	P16333	Anti Tag CoIP	25218436
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	MAPPIT	31467278
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	Y2H Array	31467278
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	SLC	31467278
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	Lumier	32814053
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	BRET	37398436
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	BRET	29997244
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	Lumier	29997244
Intra	CBLB	Q13191	GRB2	Homo sapiens	P62993	Y2H	21900206
Intra	CBLB	Q13191	LRRK2	Homo sapiens	Q5S007	Validated Y2H	32814053
Intra	CBLB	Q13191	LRRK2	Homo sapiens	Q5S007	Y2H Pooling	32814053
Intra	CBLB	Q13191	LRRK2	Homo sapiens	Q5S007	Y2H Array	32814053
Intra	CBLB	Q13191	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927
Intra	CBLB	Q13191	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	CBLB	Q13191	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	CBLB	Q13191	NCK2	Homo sapiens	O43639	Y2H Pooling	16189514
Intra	CBLB	Q13191	GORASP2	Homo sapiens	Q9H8Y8	Y2H Pooling	16189514
Intra	CBLB	Q13191	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	CBLB	Q13191	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	CBLB	Q13191	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	CBLB	Q13191	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	CBLB	Q13191	CRK	Homo sapiens	P46108	Y2H Array	25814554
Intra	CBLB	Q13191	CRK	Homo sapiens	P46108	Validated Y2H	25814554
Intra	CBLB	Q13191	CRKL	Homo sapiens	P46109	Y2H Array	25814554
Intra	CBLB	Q13191	CRKL	Homo sapiens	P46109	CoIP	10022120

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CBLB Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P78728	CBLB/RNF56 Protein, Human (HEK293, His)	Q13191-1 (A39-F426)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-141432	NX-1607	Inhibitor	99.87%	Unkown
HY-136339	Cbl-b-IN-1	Inhibitor	99.66%	Unkown
HY-155815	MS9715		99.48%	Unkown
HY-155120	Cbl-b-IN-5	Inhibitor	99.05%	Unkown
HY-156766	Cbl-b-IN-10	Inhibitor	98.85%	Unkown
HY-155477	Cbl-b-IN-15	Inhibitor	99.78%	Unkown
HY-156765	Cbl-b-IN-9	Inhibitor	98.55%	Unkown
HY-161977	Cbl-b-IN-26	Inhibitor	99.81%	Unkown
HY-156769	Cbl-b-IN-13	Inhibitor	98.46%	Unkown
HY-141431	Cbl-b-IN-2	Inhibitor	/	Unkown
HY-156768	Cbl-b-IN-12	Inhibitor	/	Unkown
HY-156762	Cbl-b-IN-6	Inhibitor	/	Unkown
HY-156763	Cbl-b-IN-7	Inhibitor	/	Unkown
HY-156764	Cbl-b-IN-8	Inhibitor	/	Unkown
HY-156767	Cbl-b-IN-11	Inhibitor	/	Unkown
HY-158171	Cbl-b-IN-17	Inhibitor	/	Unkown
HY-158173	Cbl-b-IN-19	Inhibitor	/	Unkown
HY-159608	PROTAC Cbl-b-IN-1	Degrader	/	Unkown
HY-163194	Cbl-b-IN-16	Inhibitor	/	Unkown
HY-164133	SM00465	Inhibitor	/	Unkown
HY-169005	Cbl-b-IN-27	Inhibitor	/	Unkown
HY-173311	Cbl-b-IN-28		/	Unkown
HY-179575	Cbl-b-IN-29		/	Unkown
HY-179617	Cbl-b-IN-30	Inhibitor	/	Unkown
HY-183293	Cbl-b-IN-32	Inhibitor	/	Unkown
HY-183997	Cbl-b-IN-33		/	Unkown
HY-184236	Cbl-b-IN-34	Inhibitor	/	Unkown
HY-P11479	Cbl-b-IN-31	Inhibitor	/	Unkown
HY-P11481	FITC-Acp-RpYTPEP-NH2	Ligand	/	Unkown
HY-RS01997	CBLB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08508	MMAB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-141432G	NX-1607 (GMP)	Inhibitor	/	Unkown
HY-RS17948	Cblb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24419	Cblb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CBLB	VGNC	VGNC:60421
Macaca mulatta	CBLB	VGNC	VGNC:70555
Bos taurus	CBLB	VGNC	VGNC:26809
Mus musculus	CBLB	MGD	MGI:2146430
Rattus norvegicus	CBLB	RGD	RGD:620535
Canis familiaris	CBLB	VGNC	VGNC:38759
Others	CBLB	NCBI