GLRX3 - glutaredoxin 3 Gene

Also Known as GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10539

About GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 Products (3)

mRNA Protein Name
NM_001199868.2 NP_001186797.1 glutaredoxin-3 isoform 1
NM_001321980.2 NP_001308909.1 glutaredoxin-3 isoform 2
NM_006541.5 NP_006532.2 glutaredoxin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10636891 GOA
Biological Process GO Annotation Evidence References Source
involved in [2Fe-2S] cluster assembly IDA
IDA: Inferred from direct assay
27519415 GOA
involved in cell redox homeostasis IDA
IDA: Inferred from direct assay
27519415 GOA
involved in intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
27519415 GOA
involved in iron-sulfur cluster assembly IDA
IDA: Inferred from direct assay
27519415 GOA
involved in protein maturation by iron-sulfur cluster transfer IDA
IDA: Inferred from direct assay
27519415 GOA
Cellular Component GO Annotation Evidence References Source
part of iron-sulfur cluster assembly complex IPI
IPI: Inferred from physical interaction
22309771 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLRX3 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (21 - 114)

Glutaredoxin

Glutaredoxin: Glutaredoxin (147 - 210)

Glutaredoxin

Glutaredoxin: Glutaredoxin (248 - 312)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

glutaredoxin-3

  • PKC-interacting cousin of thioredoxin

GLRX3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLRX3 O76003 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
GLRX3 O76003 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
MAPPIT
25416956
Intra
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 ADAMTSL3 Homo sapiens P82987
Validated Y2H
32296183
Intra
GLRX3 O76003 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra
GLRX3 O76003 LCE2D Homo sapiens Q5TA82
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra
GLRX3 O76003 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
GLRX3 O76003 RECK Homo sapiens Q6P9E2
Validated Y2H
32296183
Intra
GLRX3 O76003 TMEM25 Homo sapiens Q86YD3
Validated Y2H
25416956
Intra
GLRX3 O76003 OLFM3 Homo sapiens Q96PB7
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 OLFM3 Homo sapiens Q96PB7
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
Intra
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Array
25416956
Intra
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 IL10 Homo sapiens P22301
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra
GLRX3 O76003 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRT38 Homo sapiens O76015
Validated Y2H
25416956
Intra
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Anti Tag CoIP
33961781
Intra
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Anti Tag CoIP
28514442
Intra
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
Intra
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Y2H Array
25416956
Intra
GLRX3 O76003 METAP1 Homo sapiens P53582
Validated Y2H
32296183
Intra
GLRX3 O76003 RGS20 Homo sapiens O76081
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
GLRX3 O76003 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra
GLRX3 O76003 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra
GLRX3 O76003 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-4 Homo sapiens Q6L8H1
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-3 Homo sapiens Q6L8H2
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-3 Homo sapiens Q6L8H2
Y2H Array
32296183
Intra
GLRX3 O76003 CDC20B Homo sapiens Q86Y33-5
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-5 Homo sapiens Q9BYR2
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-11 Homo sapiens Q6L8G4
Validated Y2H
32296183
Intra
GLRX3 O76003 BOLA3 Homo sapiens Q53S33
Validated Y2H
32296183
Intra
GLRX3 O76003 IRX6 Homo sapiens P78412
Validated Y2H
32296183
Intra
GLRX3 O76003 STRA6 Homo sapiens Q9BX79-6
Validated Y2H
32296183
Intra
GLRX3 O76003 KLHDC9 Homo sapiens Q8NEP7
Validated Y2H
32296183
Intra
GLRX3 O76003 CA9 Homo sapiens Q16790
Validated Y2H
32296183
Intra
GLRX3 O76003 CERCAM Homo sapiens Q5T4B2
Validated Y2H
32296183
Intra
GLRX3 O76003 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81-1
NMR
26302480
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81-1
GMS
26302480
Intra
GLRX3 O76003 BOLA2 Homo sapiens Q9H3K6
Anti Tag CoIP
33961781
Intra
GLRX3 O76003 BOLA2 Homo sapiens Q9H3K6
Anti Tag CoIP
27519415
Intra
GLRX3 O76003 HEPH Homo sapiens Q9BQS7-3
Validated Y2H
32296183
Intra
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
32296183
Intra
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Y2H Array
25416956
Intra
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
25416956
Intra
GLRX3 O76003 ZNF124 Homo sapiens Q15973
Validated Y2H
32296183
Intra
GLRX3 O76003 ZNF148 Homo sapiens Q9UQR1
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 SMARCC1 Homo sapiens Q92922
Validated Y2H
32296183
Intra
GLRX3 O76003 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 PFDN5 Homo sapiens Q99471
Y2H Array
25416956
Intra
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 TRAF1 Homo sapiens Q13077
BFG-2H
27107012
Intra
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Validated Y2H
27107012
Intra
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Y2H
10636891
Intra
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Pull Down
10636891
Intra
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Imaging
10636891
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
25416956
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
32296183
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
25416956
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Pooling
16189514
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Anti Tag CoIP
33961781
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H
21516116
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
31515488
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
BiFC
25416956
Intra
GLRX3 O76003 NTF4 Homo sapiens P34130
Validated Y2H
32296183
Intra
GLRX3 O76003 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
GLRX3 O76003 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
Intra
GLRX3 O76003 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Validated Y2H
32296183
Intra
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Validated Y2H
25416956
Intra
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Y2H Array
25416956
Intra
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Y2H Array
25416956
Intra
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
25416956
Intra
GLRX3 O76003 SOX7 Homo sapiens Q9BT81
Validated Y2H
25416956
Intra
GLRX3 O76003 SOX7 Homo sapiens Q9BT81
Y2H Array
25416956
Intra
GLRX3 O76003 TCL1B Homo sapiens O95988
Validated Y2H
32296183
Intra
GLRX3 O76003 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Pooling
16189514
Intra
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
25416956
Intra
GLRX3 O76003 PLSCR1 Homo sapiens O15162
Y2H Array
25416956
Intra
GLRX3 O76003 ZNF426 Homo sapiens Q9BUY5
Y2H Array
25416956
Intra
GLRX3 O76003 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
25416956
Intra
GLRX3 O76003 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 CBLB Homo sapiens Q13191
Validated Y2H
25416956
Intra
GLRX3 O76003 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
GLRX3 O76003 COL8A1 Homo sapiens P27658
Validated Y2H
32296183
Intra
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Array
31515488
Intra
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Array
25416956
Intra
GLRX3 O76003 GRN Homo sapiens P28799
Y2H
21516116
Intra
GLRX3 O76003 GRN Homo sapiens P28799
Validated Y2H
25416956
Intra
GLRX3 O76003 PCSK5 Homo sapiens Q92824
Validated Y2H
25416956
Intra
GLRX3 O76003 FAM118A Homo sapiens Q9NWS6
Y2H Array
25416956
Intra
GLRX3 O76003 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
Intra
GLRX3 O76003 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
Intra
GLRX3 O76003 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

  • Mrx12

  • Mrx35

  • X-Linked Mental Retardation 12

  • X-Linked Mental Retardation 35
Transvestism

  • Dual-Role Transvestism

  • Fetishistic Transvestism

  • Cross Dresser

  • Transvestic Fetishism
Friedreich Ataxia

  • Friedreich Ataxia 1

  • FRDA

  • Friedreich Ataxia With Retained Reflexes

  • Frda1

  • Fa

  • Friedreich'S Ataxia

  • Hereditary Spinal Ataxia

  • Fa1

  • Friedreich'S Tabes

  • Hereditary Spinal Sclerosis

  • Spinocerebellar Ataxia, Friedreich

  • Friedreich Spinocerebellar Ataxia

  • Friedrich'S Ataxia
Transposition Of The Great Arteries, Dextro-Looped

  • Transposition Of The Great Arteries

  • DTGA1

  • Dextro-Looped Transposition Of The Great Arteries

  • DTGA

  • Congenitally Uncorrected Transposition Of The Great Arteries

  • Congenitally Uncorrected Transposition Of The Great Vessels

  • D-Tga

  • Isolated Ventriculoarterial Discordance

  • Ventriculoarterial Discordance With Atrioventricular Concordance

  • Dextro-Transposition Of The Great Arteries

  • Transposition Of The Great Vessels

  • Great Vessels Transposition

  • Transposition Of The Great Arteries, Dextro-Looped 1

  • Arteries, Great, Transposition, Dextro-Looped

  • Ventriculoarterial Discordance, Isolated

  • D-Transposition Of The Great Arteries

  • Complete Transposition

  • Tga

  • Tgv

  • Transposition Of Great Vessels

  • Transposition Of The Great Arteries Dextro-Looped 1

  • Dextro-Looped Transposition Of The Great Arteries 1

  • Discordant Ventriculoarterial Connection

  • Complete Transposition Of Great Vessels

  • Great Vessels Complete Transposition

  • Total Great Vessel Transposition

  • Transposition Of Great Arteries

  • Complete Tga - [Transposition Of The Great Arteries]

  • Tga - [Transposition Of Great Arteries]

  • Tgv - [Transposition Of Great Vessels]

  • Transposition Of Great Vessels Nos

  • Transposed Vessels Nos
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GLRX3 MGD MGI:1353653
Macaca mulatta GLRX3 VGNC VGNC:103820
Rattus norvegicus GLRX3 RGD RGD:69414
Canis familiaris GLRX3 VGNC VGNC:41275
Bos taurus GLRX3 VGNC VGNC:29417
Others GLRX3 NCBI