TMEM25 - transmembrane protein 25 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84866

About TMEM25

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,531,192-118,547,286 (from NCBI)

This gene has 30 transcripts (splice variants), 194 orthologues and 16 paralogues. Ubiquitous expression in duodenum (RPKM 15.5), small intestine (RPKM 11.2) and 24 other tissues.

Summary

Predicted to be involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Predicted to be located in late endosome and lysosome. [provided by Alliance of Genome Resources, Apr 2022]

TMEM25 Products (8)

mRNA Protein Name
NM_001144034.2 NP_001137506.1 transmembrane protein 25 isoform 2 precursor
NM_001144035.2 NP_001137507.1 transmembrane protein 25 isoform 2 precursor
NM_001144036.2 NP_001137508.1 transmembrane protein 25 isoform 3 precursor
NM_001144037.2 NP_001137509.1 transmembrane protein 25 isoform 4 precursor
NM_001144038.2 NP_001137510.1 transmembrane protein 25 isoform 5 precursor
NM_001318755.2 NP_001305684.1 transmembrane protein 25 isoform 6 precursor
NM_001318757.2 NP_001305686.1 transmembrane protein 25 isoform 7 precursor
NM_032780.4 NP_116169.2 transmembrane protein 25 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM25 Protein Structure

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (28 - 116)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

transmembrane protein 25

  • 0610039J01Rik

TMEM25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM25 Q86YD3 GLRX3 Homo sapiens O76003
Y2H Array
29892012
Intra
TMEM25 Q86YD3 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
TMEM25 Q86YD3 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMEM25 Proteins

Cat. No. Product Name Accession Purity
HY-P77245 TMEM25 Protein, Human (HEK293, His) Q86YD3-2/AAH51841.1(E27-P224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14709 TMEM25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19823 Tmem25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26319 Tmem25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM25 VGNC VGNC:47555
Bos taurus TMEM25 VGNC VGNC:36058
Mus musculus TMEM25 MGD MGI:1918937
Macaca mulatta TMEM25 VGNC VGNC:79553
Felis catus TMEM25 VGNC VGNC:66329
Rattus norvegicus TMEM25 RGD RGD:1596132
Others TMEM25 NCBI