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PCSK5 - proprotein convertase subtilisin/kexin type 5 Gene

Also Known as PC5; PC6; PC6A; SPC6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5125

About PCSK5

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:75,889,809-76,362,975 (from NCBI)

This gene has 7 transcripts (splice variants), 271 orthologues and 9 paralogues. Broad expression in small intestine (RPKM 6.4), duodenum (RPKM 5.8) and 20 other tissues.

Summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several Integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

PCSK5 Products (3)

mRNA	Protein	Name
NM_001190482.2	NP_001177411.1	proprotein convertase subtilisin/kexin type 5 isoform PC6B preproprotein
NM_001372043.1	NP_001358972.1	proprotein convertase subtilisin/kexin type 5 isoform 3 precursor
NM_006200.6	NP_006191.2	proprotein convertase subtilisin/kexin type 5 isoform PC6A preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	EXP EXP: Inferred from Experiment	16109723	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	15606899	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	8901832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	18519639	GOA
involved in embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	18519639	GOA
involved in embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	18519639	GOA
involved in kidney development	IMP IMP: Inferred from mutant phenotype	18519639	GOA
involved in peptide biosynthetic process	IDA IDA: Inferred from direct assay	8901832	GOA
involved in peptide hormone processing	IDA IDA: Inferred from direct assay	8901832	GOA
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	15606899	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	8901832	GOA
involved in renin secretion into blood stream	IEP IEP: Inferred from expression pattern	8901832	GOA
involved in signal peptide processing	IDA IDA: Inferred from direct assay	16912035	GOA
involved in viral life cycle	IEP IEP: Inferred from expression pattern	8940009	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCSK5 Protein Structure

Peptidase_S8

P_proprotein

GF_recep_IV

0
300
600
900
1200
1500
1860 a.a.

Protein Preferred Names	Protein Names
proprotein convertase subtilisin/kexin type 5	prohormone convertase 5

PCSK5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PCSK5	Q92824	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	PCSK5	Q92824	LCE3C	Homo sapiens	Q5T5A8	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	LCE3C	Homo sapiens	Q5T5A8	Validated Y2H	25416956
Intra	PCSK5	Q92824	LCE3C	Homo sapiens	Q5T5A8	Y2H Array	25416956
Intra	PCSK5	Q92824	NUFIP2	Homo sapiens	Q7Z417	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	PCSK5	Q92824	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	25416956
Intra	PCSK5	Q92824	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	PCSK5	Q92824	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	PCSK5	Q92824	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	PCSK5	Q92824	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PCSK5	Q92824	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

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Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10174	PCSK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PCSK5	VGNC	VGNC:102961
Canis familiaris	PCSK5	VGNC	VGNC:44324
Rattus norvegicus	PCSK5	RGD	RGD:620326
Macaca mulatta	PCSK5	VGNC	VGNC:75787
Bos taurus	PCSK5	VGNC	VGNC:56979
Mus musculus	PCSK5	MGD	MGI:97515
Others	PCSK5	NCBI