NUFIP2 - nuclear FMR1 interacting protein 2 Gene

Also Known as PIG1; NUFP2; 82-FIP; FIP-82; 182-FIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57532

About NUFIP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,255,839-29,294,148 (from NCBI)

This gene has 2 transcripts (splice variants) and 134 orthologues. Ubiquitous expression in bone marrow (RPKM 15.1), placenta (RPKM 12.6) and 25 other tissues.

Summary

Enables RNA binding activity. Located in cytoplasmic stress granule; cytosol; and nuclear body. Part of polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]

NUFIP2 Products (1)

mRNA Protein Name
NM_020772.3 NP_065823.1 FMR1-interacting protein NUFIP2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
12837692 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12837692 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12837692 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
26184334 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12837692 GOA
located in ribosome IDA
IDA: Inferred from direct assay
12837692 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUFIP2 Protein Structure

NUFIP2

NUFIP2: Nuclear fragile X mental retardation-interacting protein 2 (89 - 688)

  • 0
  • 200
  • 400
  • 600
  • 695 a.a.
Protein Preferred Names Protein Names

FMR1-interacting protein NUFIP2

nuclear fragile X mental retardation-interacting protein 2

  • 82 kDa FMRP-interacting protein

NUFIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUFIP2 Q7Z417 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-5 Homo sapiens P60370
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
NUFIP2 Q7Z417 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 LCE1B Homo sapiens Q5T7P3
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 LCE1B Homo sapiens Q5T7P3
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
NUFIP2 Q7Z417 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
NUFIP2 Q7Z417 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
NUFIP2 Q7Z417 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
NUFIP2 Q7Z417 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
NUFIP2 Q7Z417 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
NUFIP2 Q7Z417 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 G3BP2 Homo sapiens Q9UN86-2
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 G3BP2 Homo sapiens Q9UN86-2
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 G3BP2 Homo sapiens Q9UN86-2
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP1-5 Homo sapiens Q9BYS1
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-5 Homo sapiens Q9BYR2
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 ESM1 Homo sapiens Q9NQ30
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 ESM1 Homo sapiens Q9NQ30
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 ESM1 Homo sapiens Q9NQ30
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 PEAR1 Homo sapiens Q5VY43
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 PEAR1 Homo sapiens Q5VY43
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 AMOT Homo sapiens A2BDD9
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 AMOT Homo sapiens A2BDD9
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 COMP Homo sapiens P49747
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 COMP Homo sapiens P49747
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 LGALS13 Homo sapiens Q9UHV8
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
NUFIP2 Q7Z417 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
NUFIP2 Q7Z417 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
NUFIP2 Q7Z417 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
NUFIP2 Q7Z417 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
NUFIP2 Q7Z417 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
NUFIP2 Q7Z417 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
NUFIP2 Q7Z417 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
NUFIP2 Q7Z417 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
NUFIP2 Q7Z417 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
NUFIP2 Q7Z417 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 EFEMP2 Homo sapiens O95967
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 GRN Homo sapiens P28799
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 GRN Homo sapiens P28799
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
25416956
Intra
NUFIP2 Q7Z417 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
25416956
Intra
NUFIP2 Q7Z417 PCSK5 Homo sapiens Q92824
Validated Y2H
25416956
Intra
NUFIP2 Q7Z417 PCSK5 Homo sapiens Q92824
Y2H Array
25416956
Intra
NUFIP2 Q7Z417 RGS19 Homo sapiens P49795
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 RGS19 Homo sapiens P49795
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 FUCA2 Homo sapiens Q9BTY2
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 FUCA2 Homo sapiens Q9BTY2
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 FUCA2 Homo sapiens Q9BTY2
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 MEGF11 Homo sapiens A6BM72
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 MEGF11 Homo sapiens A6BM72
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 FBLN5 Homo sapiens Q9UBX5
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 FBLN5 Homo sapiens Q9UBX5
Y2H Prey Pooling
32296183
Intra
NUFIP2 Q7Z417 FBLN5 Homo sapiens Q9UBX5
Validated Y2H
32296183
Intra
NUFIP2 Q7Z417 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
NUFIP2 Q7Z417 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09678 NUFIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NUFIP2 VGNC VGNC:44040
Bos taurus NUFIP2 VGNC VGNC:32346
Macaca mulatta NUFIP2 VGNC VGNC:75422
Felis catus NUFIP2 VGNC VGNC:99314
Mus musculus NUFIP2 MGD MGI:1915814
Rattus norvegicus NUFIP2 RGD RGD:1596719
Others NUFIP2 NCBI