PEAR1 - platelet endothelial aggregation receptor 1 Gene

Also Known as JEDI; MEGF12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375033

About PEAR1

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,893,718-156,916,429 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 1 paralogue. Broad expression in fat (RPKM 9.8), placenta (RPKM 6.3) and 24 other tissues.

Summary

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

PEAR1 Products (3)

mRNA Protein Name
NM_001080471.3 NP_001073940.1 platelet endothelial aggregation receptor 1 isoform 1 precursor
NM_001353682.2 NP_001340611.1 platelet endothelial aggregation receptor 1 isoform 2
NM_001353683.2 NP_001340612.1 platelet endothelial aggregation receptor 1 isoform 2

PEAR1 Protein Structure

hEGF

hEGF: Human growth factor-like EGF (119 - 131)

hEGF

hEGF: Human growth factor-like EGF (290 - 302)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (319 - 358)

hEGF

hEGF: Human growth factor-like EGF (423 - 434)

hEGF

hEGF: Human growth factor-like EGF (552 - 563)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (622 - 665)

hEGF

hEGF: Human growth factor-like EGF (679 - 691)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1037 a.a.
Protein Preferred Names Protein Names

platelet endothelial aggregation receptor 1

  • multiple EGF-like domains protein 12

PEAR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PEAR1 Q5VY43 KRTAP4-5 Homo sapiens Q9BYR2
Validated Y2H
32296183
Intra
PEAR1 Q5VY43 NUFIP2 Homo sapiens Q7Z417
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aspirin Allergy

  • Acetylsalicylic Acid Allergy

  • Asa Allergy
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10312 PEAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18541 Pear1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25023 Pear1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PEAR1 MGD MGI:1920432
Felis catus PEAR1 VGNC VGNC:64108
Rattus norvegicus PEAR1 RGD RGD:1305653
Canis familiaris PEAR1 VGNC VGNC:44408
Macaca mulatta PEAR1 VGNC VGNC:106468
Bos taurus PEAR1 VGNC VGNC:32734
Others PEAR1 NCBI