MEGF11 - multiple EGF like domains 11 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84465

About MEGF11

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,895,299-66,253,750 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 198 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues.

Summary

Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MEGF11 Products (9)

mRNA Protein Name
NM_001385028.1 NP_001371957.1 multiple epidermal growth factor-like domains protein 11 isoform 1 precursor
NM_001385029.1 NP_001371958.1 multiple epidermal growth factor-like domains protein 11 isoform 3 precursor
NM_001385030.1 NP_001371959.1 multiple epidermal growth factor-like domains protein 11 isoform 4
NM_001385031.1 NP_001371960.1 multiple epidermal growth factor-like domains protein 11 isoform 5
NM_001385032.1 NP_001371961.1 multiple epidermal growth factor-like domains protein 11 isoform 6
NM_001385033.1 NP_001371962.1 multiple epidermal growth factor-like domains protein 11 isoform 7 precursor
NM_001387150.1 NP_001374079.1 multiple epidermal growth factor-like domains protein 11 isoform 2 precursor
NM_001387151.1 NP_001374080.1 multiple epidermal growth factor-like domains protein 11 isoform 8 precursor
NM_032445.3 NP_115821.2 multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEGF11 Protein Structure

hEGF

hEGF: Human growth factor-like EGF (203 - 215)

hEGF

hEGF: Human growth factor-like EGF (247 - 258)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (275 - 320)

hEGF

hEGF: Human growth factor-like EGF (333 - 344)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (362 - 407)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (450 - 493)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (579 - 619)

hEGF

hEGF: Human growth factor-like EGF (639 - 650)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (667 - 703)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (753 - 790)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (796 - 824)

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  • 1044 a.a.
Protein Preferred Names Protein Names

multiple epidermal growth factor-like domains protein 11

  • multiple EGF-like domains protein 11

MEGF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MEGF11 A6BM72 NUFIP2 Homo sapiens Q7Z417
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

  • EMARDD

  • Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant

  • Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome

  • Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia

  • Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Folic Acid Deficiency Anemia

  • Folate Deficiency Anaemia

  • Folic Acid Deficiency Anaemia

  • Folate Deficiency Anemia

  • Folate-Deficiency Anaemia

  • Folate-Deficiency Anemia

  • Folate-Deficient Megaloblastic Anaemia

  • Megaloblastic Anemia Due To Folate Deficiency

  • Anaemia Of Folate Deficiency

  • Folate Or Folic Acid Deficiency Anaemia Nos

  • Folic Acid Deficiency Anaemia Nos

  • Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency

  • Dietary Folic Acid Deficiency Anaemia

  • Dietary Folate Deficiency Anaemia

  • Folate Deficiency Anaemia Due To Dietary Causes

  • Goat'S Milk Anaemia

  • Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement

  • Megaloblastic Anaemia Due To Increased Requirements Of Folate

  • Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders

  • Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate

  • Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08315 MEGF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MEGF11 MGD MGI:1920951
Felis catus MEGF11 VGNC VGNC:80915
Macaca mulatta MEGF11 VGNC VGNC:84376
Bos taurus MEGF11 VGNC VGNC:55123
Rattus norvegicus MEGF11 RGD RGD:1582797
Canis familiaris MEGF11 VGNC VGNC:59120
Others MEGF11 NCBI