MEGF11 - multiple EGF like domains 11 Gene

Homo sapiens

Gene ID: 84465 | Gene type: protein coding

About MEGF11

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,895,299-66,253,750 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 198 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues.

Summary

Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MEGF11 Products(9)

mRNA	Protein	Name
NM_001385028.1	NP_001371957.1	multiple epidermal growth factor-like domains protein 11 isoform 1 precursor
NM_001385029.1	NP_001371958.1	multiple epidermal growth factor-like domains protein 11 isoform 3 precursor
NM_001385030.1	NP_001371959.1	multiple epidermal growth factor-like domains protein 11 isoform 4
NM_001385031.1	NP_001371960.1	multiple epidermal growth factor-like domains protein 11 isoform 5
NM_001385032.1	NP_001371961.1	multiple epidermal growth factor-like domains protein 11 isoform 6
NM_001385033.1	NP_001371962.1	multiple epidermal growth factor-like domains protein 11 isoform 7 precursor
NM_001387150.1	NP_001374079.1	multiple epidermal growth factor-like domains protein 11 isoform 2 precursor
NM_001387151.1	NP_001374080.1	multiple epidermal growth factor-like domains protein 11 isoform 8 precursor
NM_032445.3	NP_115821.2	multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

MEGF11 Protein Structure

hEGF

Laminin_EGF

hEGF

Laminin_EGF

hEGF

Laminin_EGF

0
200
400
600
800
1044 a.a.

Protein Preferred Names

Protein Names

multiple epidermal growth factor-like domains protein 11

multiple EGF-like domains protein 11

Related Diseases

Diseases

Alias

Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

EMARDD	Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant
Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome	Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia
Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia

Folic Acid Deficiency Anemia

Folate Deficiency Anaemia	Folic Acid Deficiency Anaemia
Folate Deficiency Anemia	Folate-Deficiency Anaemia
Folate-Deficiency Anemia	Folate-Deficient Megaloblastic Anaemia
Megaloblastic Anemia Due To Folate Deficiency	Anaemia Of Folate Deficiency
Folate Or Folic Acid Deficiency Anaemia Nos	Folic Acid Deficiency Anaemia Nos
Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency	Dietary Folic Acid Deficiency Anaemia
Dietary Folate Deficiency Anaemia	Folate Deficiency Anaemia Due To Dietary Causes
Goat'S Milk Anaemia	Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement
Megaloblastic Anaemia Due To Increased Requirements Of Folate	Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders
Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate	Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08315	MEGF11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MEGF11	MGD	MGI:1920951
Felis catus	MEGF11	VGNC	VGNC:80915
Macaca mulatta	MEGF11	VGNC	VGNC:84376
Bos taurus	MEGF11	VGNC	VGNC:55123
Rattus norvegicus	MEGF11	RGD	RGD:1582797
Canis familiaris	MEGF11	VGNC	VGNC:59120

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