FUCA2 - alpha-L-fucosidase 2 Gene

Also Known as dJ20N2.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2519

About FUCA2

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:143,494,812-143,511,720 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 24.8), colon (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric Cancer cells. [provided by RefSeq, Aug 2010]

FUCA2 Products (1)

mRNA Protein Name
NM_032020.5 NP_114409.2 plasma alpha-L-fucosidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-L-fucosidase activity IDA
IDA: Inferred from direct assay
19666478 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in fucose metabolic process IDA
IDA: Inferred from direct assay
19666478 GOA
involved in glycoside catabolic process IDA
IDA: Inferred from direct assay
19666478 GOA
involved in regulation of entry of bacterium into host cell IMP
IMP: Inferred from mutant phenotype
19666478 GOA
involved in response to bacterium IMP
IMP: Inferred from mutant phenotype
19666478 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19666478 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUCA2 Protein Structure

Alpha_L_fucos

Alpha_L_fucos: Alpha-L-fucosidase (21 - 369)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

plasma alpha-L-fucosidase

  • I+/--L-fucosidase 2

FUCA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FUCA2 Q9BTY2 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
FUCA2 Q9BTY2 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
FUCA2 Q9BTY2 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
FUCA2 Q9BTY2 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
FUCA2 Q9BTY2 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
FUCA2 Q9BTY2 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fucosidosis

  • Alpha-L-Fucosidase Deficiency

  • Fucosidase Deficiency Disease

  • A-Fucosidase Deficiency

  • Alpha Fucosidase Deficiency

  • Lysosomal Storage Disease Caused By Defective Alpha-L-Fucosidase With Accumulation Of Fucose In The Tissues

  • Alpha-Fucosidase Deficiency

  • Fucosidase Deficiency

  • FUCA1D
Laryngotracheitis
Angiokeratoma

  • Angiokeratoma Of Skin

  • Cutaneous Angiokeratoma

  • Skin Angiokeratoma
Skin Hemangioma

  • Angioma Of The Skin

  • Angiomatous Naevus Of Skin

  • Hemangioma Of Skin
Scheie Syndrome

  • Mucopolysaccharidosis Type Is

  • Alpha-L-Iduronidase Deficiency

  • Mucopolysaccharidosis Type I

  • Mucopolysaccharidosis I

  • Hurler-Scheie Syndrome

  • Mucopolysaccharidosis Type 1

  • Mucopolysaccharidosis Is

  • Mucopolysaccharidosis Type 1s

  • Mucopolysaccharidosis Type V

  • Hurler Syndrome

  • Idua Deficiency

  • Mps I

  • MPS1S

  • Mps1-S

  • Mucopolysaccharidosis Type V, Formerly

  • Mps V, Formerly

  • Mps5, Formerly

  • Lipochondrodystrophy

  • Mpsis

  • Mucopolysaccharidosis, Type I

  • Iduronidase Deficiency Disease

  • Mps I - Hurler Syndrome

  • Mucopolysaccharidosis, Mps-I

  • Mucopolysaccharidosis, Type 1

  • Attenuated Mps I

  • Mps 1

  • Scheie Syndrome Formerly Known As Mucopolysaccharidosis Type V)

  • Severe Mps I

  • Mps I H

  • Mps I H-S

  • Mps I S

  • Mps1

  • Mpsi

  • Mucopolysaccharidosis 1s

  • Mps Is

  • Mps-Is

  • Mps V

  • Mucopolysaccharidosis V

  • Pfaundler-Hurler Syndrome

  • L-Iduronidase Deficiency

  • Dysostosis Multiplex

  • Dysostosis Multiplex Syndrome

  • Gargoylism

  • Mps1 - [Mucopolysaccharidosis Type 1]
Hurler Syndrome

  • Mucopolysaccharidosis Ih

  • Mucopolysaccharidosis Type Ih

  • Mps1-H

  • MPS1H

  • Hurler Disease

  • Mpsih

  • Mucopolysaccharidosis Type 1h

  • Alpha-L-Iduronidase Deficiency

  • Dysostosis Multiplex

  • Dysostosis Multiplex Syndrome

  • Gargoylism

  • Hurler Disease Mps Type 1h

  • Hurler-Pfaundler Syndrome

  • L-Iduronidase Deficiency, Hurler Type

  • Mucopolysaccharidosis Type I Severe Form

  • Mucopolysaccharidosis 1h

  • Hurler'S Syndrome

  • Mps Ih

  • Mps-Ih

  • Pfaundler-Hurler Syndrome

  • Mucopolysaccharidosis I
Hurler-Scheie Syndrome

  • Mucopolysaccharidosis Type Ih/S

  • Mucopolysaccharidosis Ih/S

  • MPS1H/S

  • Mpsih/S

  • Mucopolysaccharidosis Type 1h/S

  • Mps1-Hs

  • Alpha-L-Iduronidase Deficiency

  • Mucopolysaccharidosis I

  • Mucopolysaccharidosis 1h/S

  • Mps-Ih/S
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05144 FUCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FUCA2 RGD RGD:1303053
Macaca mulatta FUCA2 VGNC VGNC:72827
Mus musculus FUCA2 MGD MGI:1914098
Bos taurus FUCA2 VGNC VGNC:29141
Felis catus FUCA2 VGNC VGNC:62388
Canis familiaris FUCA2 VGNC VGNC:53717
Others FUCA2 NCBI