FHL5 - four and a half LIM domains 5 Gene

Homo sapiens

Also known as ACT; FHL-5; dJ393D12.2; 1700027G07Rik

Gene ID: 9457 | Gene type: protein coding

About FHL5

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,562,574-96,618,626 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.0), fat (RPKM 12.3) and 18 other tissues.

Summary

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

FHL5 Products(4)

mRNA	Protein	Name
NM_001170807.3	NP_001164278.1	four and a half LIM domains protein 5
NM_001322466.2	NP_001309395.1	four and a half LIM domains protein 5
NM_001322467.1	NP_001309396.1	four and a half LIM domains protein 5
NM_020482.6	NP_065228.4	four and a half LIM domains protein 5

FHL5 Protein Structure

LIM

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

four and a half LIM domains protein 5

LIM protein ACT

Related Diseases

Diseases

Alias

Migraine Without Aura

Common Migraine	Migraine With Or Without Aura, Susceptibility To
Migraine Without Aura, Susceptibility To	Acute Migraine Without Aura

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04937	FHL5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FHL5	VGNC	VGNC:62267
Rattus norvegicus	FHL5	RGD	RGD:1307056
Canis familiaris	FHL5	VGNC	VGNC:40874
Mus musculus	FHL5	MGD	MGI:1913192
Bos taurus	FHL5	VGNC	VGNC:29002
Macaca mulatta	FHL5	VGNC	VGNC:72521
Others	FHL5	NCBI