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FHL5 - four and a half LIM domains 5 Gene

Also Known as ACT; FHL-5; dJ393D12.2; 1700027G07Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9457

About FHL5

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,562,574-96,618,626 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.0), fat (RPKM 12.3) and 18 other tissues.

Summary

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

FHL5 Products (4)

mRNA	Protein	Name
NM_001170807.3	NP_001164278.1	four and a half LIM domains protein 5
NM_001322466.2	NP_001309395.1	four and a half LIM domains protein 5
NM_001322467.1	NP_001309396.1	four and a half LIM domains protein 5
NM_020482.6	NP_065228.4	four and a half LIM domains protein 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHL5 Protein Structure

LIM

0
100
200
284 a.a.

Protein Preferred Names	Protein Names
four and a half LIM domains protein 5	LIM protein ACT

FHL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FHL5	Q5TD97	ZNF131	Homo sapiens	P52739-2	Anti Tag CoIP	28514442
Intra	FHL5	Q5TD97	ZNF564	Homo sapiens	Q8TBZ8	Validated Y2H	32296183
Intra	FHL5	Q5TD97	KIR2DL4	Homo sapiens	Q99706	Validated Y2H	32296183
Intra	FHL5	Q5TD97	HDX	Homo sapiens	Q7Z353	Validated Y2H	32296183
Intra	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	FHL5	Q5TD97	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	FHL5	Q5TD97	IP6K3	Homo sapiens	Q96PC2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	FHL5	Q5TD97	SHFL	Homo sapiens	Q9NUL5-4	Validated Y2H	32296183
Intra	FHL5	Q5TD97	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	FHL5	Q5TD97	CDC20B	Homo sapiens	Q86Y33-5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	FHL5	Q5TD97	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	FHL5	Q5TD97	ZNF613	Homo sapiens	Q6PF04	Validated Y2H	32296183
Intra	FHL5	Q5TD97	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
Intra	FHL5	Q5TD97	BBC3	Homo sapiens	Q96PG8	Validated Y2H	32296183
Intra	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	FHL5	Q5TD97	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	FHL5	Q5TD97	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	FHL5	Q5TD97	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Cross	FHL5	Q5TD97	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	FHL5	Q5TD97	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	FHL5	Q5TD97	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	FHL5	Q5TD97	PLEKHA2	Homo sapiens	Q9HB19	Validated Y2H	32296183
Intra	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	FHL5	Q5TD97	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	FHL5	Q5TD97	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF251	Homo sapiens	Q9BRH9	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF440	Homo sapiens	Q8IYI8	Validated Y2H	32296183
Intra	FHL5	Q5TD97	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	FHL5	Q5TD97	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	FHL5	Q5TD97	DNAL4	Homo sapiens	O96015	Y2H Pooling	16189514
Intra	FHL5	Q5TD97	DNAL4	Homo sapiens	O96015	Y2H	21516116
Intra	FHL5	Q5TD97	RAB3IL1	Homo sapiens	Q8TBN0	Validated Y2H	32296183
Intra	FHL5	Q5TD97	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ATOSB	Homo sapiens	Q7L5A3	Y2H	21516116
Intra	FHL5	Q5TD97	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
Intra	FHL5	Q5TD97	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183
Intra	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Anti Tag CoIP	33961781
Intra	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Anti Tag CoIP	28514442
Intra	FHL5	Q5TD97	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	FHL5	Q5TD97	NPDC1	Homo sapiens	Q9NQX5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	HEY2	Homo sapiens	Q9UBP5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
Intra	FHL5	Q5TD97	CTSZ	Homo sapiens	Q9UBR2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	ADAMTSL5	Homo sapiens	Q6ZMM2	Validated Y2H	32296183
Intra	FHL5	Q5TD97	RAB26	Homo sapiens	Q9ULW5	Validated Y2H	32296183
Intra	FHL5	Q5TD97	RAB26	Homo sapiens	Q9ULW5	Y2H Prey Pooling	32296183
Intra	FHL5	Q5TD97	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FHL5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810001	FHL-5 Antibody (YA9345)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Migraine Without Aura	Common Migraine Migraine With Or Without Aura, Susceptibility To Migraine Without Aura, Susceptibility To Acute Migraine Without Aura
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04937	FHL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13990	STXBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18613	Fhl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25099	Fhl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FHL5	VGNC	VGNC:62267
Rattus norvegicus	FHL5	RGD	RGD:1307056
Canis familiaris	FHL5	VGNC	VGNC:40874
Mus musculus	FHL5	MGD	MGI:1913192
Bos taurus	FHL5	VGNC	VGNC:29002
Macaca mulatta	FHL5	VGNC	VGNC:72521
Others	FHL5	NCBI