country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DNAL4 - dynein axonemal light chain 4 Gene

Also Known as MRMV3; PIG27

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10126

About DNAL4

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,778,508-38,794,143 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 25.2), thyroid (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

DNAL4 Products (1)

mRNA	Protein	Name
NM_005740.3	NP_005731.1	dynein axonemal light chain 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAL4 Protein Structure

Dynein_light

0
100
105 a.a.

Protein Preferred Names	Protein Names
dynein axonemal light chain 4	dynein light chain, outer arm 4

DNAL4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAL4	O96015	NUDT22	Homo sapiens	Q9BRQ3	Validated Y2H	32296183
Intra	DNAL4	O96015	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	DNAL4	O96015	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	DNAL4	O96015	NFATC2IP	Homo sapiens	Q8NCF5-2	Y2H Prey Pooling	32296183
Intra	DNAL4	O96015	NFATC2IP	Homo sapiens	Q8NCF5-2	Validated Y2H	32296183
Intra	DNAL4	O96015	NFATC2IP	Homo sapiens	Q8NCF5-2	Y2H Array	32296183
Intra	DNAL4	O96015	DYNLL1	Homo sapiens	P63167	Validated Y2H	32296183
Intra	DNAL4	O96015	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	33961781
Intra	DNAL4	O96015	CAMK2D	Homo sapiens	Q13557	Y2H Array	25416956
Intra	DNAL4	O96015	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	33961781
Intra	DNAL4	O96015	CAMK2D	Homo sapiens	Q13557	Y2H Array	31515488
Intra	DNAL4	O96015	CAMK2D	Homo sapiens	Q13557	Validated Y2H	25416956
Intra	DNAL4	O96015	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	DNAL4	O96015	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Y2H Pooling	16189514
Intra	DNAL4	O96015	FHL5	Homo sapiens	Q5TD97	Y2H Array	31515488
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	31515488
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Y2H Prey Pooling	25416956
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	25416956
Intra	DNAL4	O96015	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	25416956
Intra	DNAL4	O96015	DYNLL2	Homo sapiens	Q96FJ2	Anti Tag CoIP	33961781
Intra	DNAL4	O96015	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	DNAL4	O96015	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	DNAL4	O96015	GNA14	Homo sapiens	O95837	Validated Y2H	25416956
Intra	DNAL4	O96015	GNA14	Homo sapiens	O95837	Y2H Array	25416956
Intra	DNAL4	O96015	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	DNAL4	O96015	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	DNAL4	O96015	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mirror Movements 3	MRMV3 Mirror Movements, Type 3
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1
Expressive Language Disorder	Developmental Expressive Language Disorder
Necrotizing Ulcerative Gingivitis	Acute Necrotizing Ulcerative Gingivitis Anug Vincent Angina Vincent'S Disease Acute Necrotising Ulcerative Gingivitis Acute Necrotising Ulcerative Gingivostomatitis Acute Necrotizing Ulcerative Gingivostomatitis Acute Ulceromembranous Gingivitis Angina - Vincents Early Acute Necrotising Gingivitis Trench Mouth Vincent'S Angina Vincent'S Angina - Pharyngitis Vincent'S Infection, Any Site Acute Membranous Gingivitis Fusospirillary Gingivitis Fusospirillosis Phagedenic Gingivitis Vincent'S Gingivitis Vincent'S Infection Vincent'S Stomatitis Gingivitis, Necrotizing Ulcerative
Suppurative Otitis Media	Otitis Media With Effusion - Purulent Purulent Otitis Media Otitis Media, Suppurative
Klippel-Feil Syndrome	Cervical Vertebral Fusion Congenital Dystrophia Brevicollis Cervical Fusion Syndrome Klippel-Feil Deformity Autosomal Dominant Klippel-Feil Syndrome Congenital Synostosis Of Cervical Vertebrae Klippel-Feil And Turner Syndrome Klippel-Feil Deformity, Deafness And Facial Asymmetry Klippel Feil Syndrome Cervical Vertebral Fusion Syndrome Dystrophia Brevicollis Congenita Fusion Of Cervical Vertebrae Kfs Klippel-Feil Sequence Vertebral Cervical Fusion Syndrome Klippel-Feil Syndrome, Autosomal Dominant Klippel-Feil Malformation Isolated Klippel-Feil Syndrome
Dandy-Walker Syndrome	Dandy-Walker Malformation DWS Atresia Of Foramina Of Magendie And Luschka Dandy-Walker Complex Dandy-Walker Cyst Dandy-Walker Deformity Dandy Walker Cyst Dw Complex Dandy-Walker Syndrome Or Malformation Dandy-Walker Variant Mega Cisterna Magna Dwm Hydrocephalus, Internal, Dandy-Walker Type Hydrocephalus, Noncommunicating, Dandy-Walker Type Luschka-Magendie Foramina Atresia Isolated Dandy-Walker Malformation Mega-Cisterna Magna Dandy Walker Variant Atresia Of Foramen Of Luschka Atresia Of Foramen Of Magendie Congenital Blockage Of Foramen Magendie
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03892	DNAL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAL4	VGNC	VGNC:71945
Rattus norvegicus	DNAL4	RGD	RGD:1309099
Bos taurus	DNAL4	VGNC	VGNC:56196
Mus musculus	DNAL4	MGD	MGI:1859217
Felis catus	DNAL4	VGNC	VGNC:82472
Canis familiaris	DNAL4	VGNC	VGNC:40022
Others	DNAL4	NCBI