2. Gene
  3. CAMK2D - calcium/calmodulin dependent protein kinase II delta Gene

CAMK2D - calcium/calmodulin dependent protein kinase II delta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAMKD

Gene ID: 817 | Gene type: protein coding

About CAMK2D

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:113,451,032-113,761,738 (from NCBI)

This gene has 38 transcripts (splice variants), 99 orthologues and 22 paralogues. Ubiquitous expression in heart (RPKM 23.1), brain (RPKM 14.9) and 24 other tissues.

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the Enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

CAMK2D Products(48)

mRNA Protein Name
NM_001221.4 NP_001212.2 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3
NM_001321566.2 NP_001308495.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6
NM_001321567.2 NP_001308496.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7
NM_001321568.2 NP_001308497.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8
NM_001321569.2 NP_001308498.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9
NM_001321570.2 NP_001308499.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 10
NM_001321571.2 NP_001308500.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 11
NM_001321572.2 NP_001308501.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 12
NM_001321573.2 NP_001308502.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 13
NM_001321574.2 NP_001308503.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 14
NM_001321575.2 NP_001308504.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 15
NM_001321576.2 NP_001308505.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 16
NM_001321577.2 NP_001308506.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 17
NM_001321578.2 NP_001308507.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321579.2 NP_001308508.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 19
NM_001321580.2 NP_001308509.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 20
NM_001321581.2 NP_001308510.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 21
NM_001321582.2 NP_001308511.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 22
NM_001321583.2 NP_001308512.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 23
NM_001321584.2 NP_001308513.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 24
NM_001321585.2 NP_001308514.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321586.2 NP_001308515.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 25
NM_001321587.2 NP_001308516.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 26
NM_001321588.2 NP_001308517.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 27
NM_001321589.2 NP_001308518.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_001321590.2 NP_001308519.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 28
NM_001321591.2 NP_001308520.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 29
NM_001321592.2 NP_001308521.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 30
NM_001396964.1 NP_001383893.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 31
NM_001396965.1 NP_001383894.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 32
NM_001396966.1 NP_001383895.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 33
NM_001396967.1 NP_001383896.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 34
NM_001399855.1 NP_001386784.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 35
NM_001399856.1 NP_001386785.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 36
NM_001399857.1 NP_001386786.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 37
NM_001399858.1 NP_001386787.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 38
NM_001399859.1 NP_001386788.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 39
NM_001399860.1 NP_001386789.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 40
NM_001399861.1 NP_001386790.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 41
NM_001399862.1 NP_001386791.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 42
NM_001399863.1 NP_001386792.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 43
NM_001399864.1 NP_001386793.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 44
NM_001399865.1 NP_001386794.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 45 precursor
NM_172114.2 NP_742112.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_172115.3 NP_742113.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172127.3 NP_742125.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172128.3 NP_742126.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2
NM_172129.2 NP_742127.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4

CAMK2D Protein Structure

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (346 - 473)

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  • 499 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit delta

CaM kinase II delta subunit

Related Diseases

Diseases Alias
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1dd

Dilated Cardiomyopathy 1dd

CMD1DD

Cardiomyopathy, Dilated 1dd

Cardiomyopathy, Dilated, Type 1dd
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124638 MNK inhibitor 9 Inhibitor / Unkown
HY-RS01858 CAMK2D Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CAMK2D MGD MGI:1341265
Macaca mulatta CAMK2D VGNC VGNC:100206
Bos taurus CAMK2D VGNC VGNC:53692
Rattus norvegicus CAMK2D RGD RGD:2263
Felis catus CAMK2D VGNC VGNC:60333
Canis familiaris CAMK2D VGNC VGNC:57416
Others CAMK2D NCBI