CAMK2D - calcium/calmodulin dependent protein kinase II delta Gene

Also Known as CAMKD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 817

About CAMK2D

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:113,451,032-113,761,738 (from NCBI)

This gene has 38 transcripts (splice variants), 99 orthologues and 22 paralogues. Ubiquitous expression in heart (RPKM 23.1), brain (RPKM 14.9) and 24 other tissues.

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

CAMK2D Products (48)

mRNA Protein Name
NM_001221.4 NP_001212.2 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3
NM_001321566.2 NP_001308495.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6
NM_001321567.2 NP_001308496.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7
NM_001321568.2 NP_001308497.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8
NM_001321569.2 NP_001308498.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9
NM_001321570.2 NP_001308499.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 10
NM_001321571.2 NP_001308500.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 11
NM_001321572.2 NP_001308501.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 12
NM_001321573.2 NP_001308502.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 13
NM_001321574.2 NP_001308503.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 14
NM_001321575.2 NP_001308504.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 15
NM_001321576.2 NP_001308505.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 16
NM_001321577.2 NP_001308506.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 17
NM_001321578.2 NP_001308507.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321579.2 NP_001308508.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 19
NM_001321580.2 NP_001308509.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 20
NM_001321581.2 NP_001308510.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 21
NM_001321582.2 NP_001308511.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 22
NM_001321583.2 NP_001308512.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 23
NM_001321584.2 NP_001308513.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 24
NM_001321585.2 NP_001308514.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor
NM_001321586.2 NP_001308515.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 25
NM_001321587.2 NP_001308516.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 26
NM_001321588.2 NP_001308517.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 27
NM_001321589.2 NP_001308518.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_001321590.2 NP_001308519.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 28
NM_001321591.2 NP_001308520.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 29
NM_001321592.2 NP_001308521.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 30
NM_001396964.1 NP_001383893.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 31
NM_001396965.1 NP_001383894.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 32
NM_001396966.1 NP_001383895.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 33
NM_001396967.1 NP_001383896.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 34
NM_001399855.1 NP_001386784.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 35
NM_001399856.1 NP_001386785.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 36
NM_001399857.1 NP_001386786.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 37
NM_001399858.1 NP_001386787.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 38
NM_001399859.1 NP_001386788.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 39
NM_001399860.1 NP_001386789.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 40
NM_001399861.1 NP_001386790.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 41
NM_001399862.1 NP_001386791.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 42
NM_001399863.1 NP_001386792.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 43
NM_001399864.1 NP_001386793.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 44
NM_001399865.1 NP_001386794.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 45 precursor
NM_172114.2 NP_742112.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5
NM_172115.3 NP_742113.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172127.3 NP_742125.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1
NM_172128.3 NP_742126.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2
NM_172129.2 NP_742127.1 calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
22514276 GOA
enables calmodulin binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20668654 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22514276 GOA
enables sodium channel inhibitor activity IDA
IDA: Inferred from direct assay
22514276 GOA
enables titin binding IPI
IPI: Inferred from physical interaction
23283722 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
22514276 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
22514276 GOA
involved in negative regulation of sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
22514276 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
22514276 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
22514276 GOA
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
17179159 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
22514276 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17179159 GOA
involved in regulation of cellular localization IMP
IMP: Inferred from mutant phenotype
17179159 GOA
involved in regulation of membrane depolarization IDA
IDA: Inferred from direct assay
22514276 GOA
involved in regulation of relaxation of cardiac muscle IDA
IDA: Inferred from direct assay
23283722 GOA
Cellular Component GO Annotation Evidence References Source
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: Inferred from direct assay
20668654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2D Protein Structure

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (346 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type II subunit delta

  • CaM kinase II delta subunit

CAMK2D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAMK2D Q13557 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
25416956
Intra
CAMK2D Q13557 EPHA10 Homo sapiens Q5JZY3-3
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 CAMK2B Homo sapiens Q13554
Anti Tag CoIP
33961781
Intra
CAMK2D Q13557 CAMK2B Homo sapiens Q13554
Pull Down
32707033
Intra
CAMK2D Q13557 CAMK2G Homo sapiens Q13555
Anti Tag CoIP
33961781
Intra
CAMK2D Q13557 CAMK2G Homo sapiens Q13555
Pull Down
32707033
Intra
CAMK2D Q13557 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
33961781
Intra
CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Y2H Array
31515488
Intra
CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
Intra
CAMK2D Q13557 CAMK2D Homo sapiens Q13557
Y2H Array
25416956
Intra
CAMK2D Q13557 CAMK2D Homo sapiens Q13557
X-Ray Diffraction
20668654
Intra
CAMK2D Q13557 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
CAMK2D Q13557 TNPO2 Homo sapiens O14787
Validated Y2H
25416956
Intra
CAMK2D Q13557 TNPO2 Homo sapiens O14787
Y2H Array
25416956
Intra
CAMK2D Q13557 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
25416956
Intra
CAMK2D Q13557 MRPL11 Homo sapiens Q9Y3B7
Y2H Array
31515488
Intra
CAMK2D Q13557 FKBP1B Homo sapiens P68106
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 SCN5A Homo sapiens Q14524
Protein Kinase Assay
22514276
Intra
CAMK2D Q13557 SCN5A Homo sapiens Q14524
Anti Bait CoIP
22514276
Intra
CAMK2D Q13557 MOAP1 Homo sapiens Q96BY2
Y2H Array
25416956
Intra
CAMK2D Q13557 MOAP1 Homo sapiens Q96BY2
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 FXR2 Homo sapiens P51116
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra
CAMK2D Q13557 DNAL4 Homo sapiens O96015
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra
CAMK2D Q13557 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Array
31515488
Intra
CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Prey Pooling
25416956
Intra
CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Validated Y2H
25416956
Intra
CAMK2D Q13557 TTC5 Homo sapiens Q8N0Z6
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CAMK2D Antibodies

Cat. No. Product Name Application Reactivity
HY-P82592 CaMKII delta Antibody (YA2337) WB Human, Rat
HY-P82592A CaMKII delta Antibody (YA2337)(PBS only) WB Human, Rat
HY-P84930 CaMKII Antibody (YA4627) WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue Human, Mouse, Rat, Monkey, Pig
HY-P86066 Phospho-CaMKIIβ/γ/δ Antibody (YA5758) IHC-P, ICC/IF Human, Rat, Mouse

Related Diseases

Diseases Alias
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1dd

  • Dilated Cardiomyopathy 1dd

  • CMD1DD

  • Cardiomyopathy, Dilated 1dd

  • Cardiomyopathy, Dilated, Type 1dd
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124638 MNK inhibitor 9 Inhibitor 99.38% Unkown
HY-RS29514 Camk2d Mouse Pre-designed siRNA Set A / Unkown
HY-E70797 Biotin-CaMK2δ CAMK2D Recombinant Human Active Protein Kinase / Unkown
HY-RS01858 CAMK2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CAMK2D MGD MGI:1341265
Macaca mulatta CAMK2D VGNC VGNC:100206
Bos taurus CAMK2D VGNC VGNC:53692
Rattus norvegicus CAMK2D RGD RGD:2263
Felis catus CAMK2D VGNC VGNC:60333
Canis familiaris CAMK2D VGNC VGNC:57416
Others CAMK2D NCBI