TTC5 - tetratricopeptide repeat domain 5 Gene

Homo sapiens

Also known as Strap; NEDCAFD

Gene ID: 91875 | Gene type: protein coding

About TTC5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,286,227-20,305,951 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTC5 Products(1)

mRNA	Protein	Name
NM_138376.3	NP_612385.2	tetratricopeptide repeat protein 5

TTC5 Protein Structure

TPR_11

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

tetratricopeptide repeat protein 5

TPR repeat protein 5

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Cerebral Atrophy And Variable Facial Dysmorphism

NEDCAFD

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Pseudobulbar Palsy

Pseudobulbar Paralysis

Tubulinopathy

Tubulinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15216	TTC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TTC5	RGD	RGD:1311284
Canis familiaris	TTC5	VGNC	VGNC:47960
Mus musculus	TTC5	MGD	MGI:2683584
Felis catus	TTC5	VGNC	VGNC:66674
Bos taurus	TTC5	VGNC	VGNC:36479
Macaca mulatta	TTC5	VGNC	VGNC:79190