CAMK2B - calcium/calmodulin dependent protein kinase II beta Gene

Also Known as CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 816

About CAMK2B

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,217,154-44,326,013 (from NCBI)

This gene has 49 transcripts (splice variants), 255 orthologues, 22 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues.

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with Calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CAMK2B Products (9)

mRNA	Protein	Name
NM_001220.5	NP_001211.3	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1
NM_001293170.2	NP_001280099.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172078.3	NP_742075.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2
NM_172079.3	NP_742076.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3
NM_172080.3	NP_742077.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4
NM_172081.3	NP_742078.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5
NM_172082.3	NP_742079.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6
NM_172083.3	NP_742080.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7
NM_172084.3	NP_742081.1	calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	31930741	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20668654	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18817731	GOA
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	29100089	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcium- and calmodulin-dependent protein kinase complex	IDA IDA: Inferred from direct assay	20668654	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2B Protein Structure

Pkinase

CaMKII_AD

0
200
400
600
666 a.a.

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase type II subunit beta	CaM kinase II beta subunit

CAMK2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAMK2B	Q13554	b3kwq7_human	Homo sapiens	B3KWQ7	Y2H Array	25416956
Intra	CAMK2B	Q13554	b3kwq7_human	Homo sapiens	B3KWQ7	Validated Y2H	25416956
Intra	CAMK2B	Q13554	b3kwq7_human	Homo sapiens	B3KWQ7	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	KRTAP10-11	Homo sapiens	P60412	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	25416956
Intra	CAMK2B	Q13554	SPRYD7	Homo sapiens	Q5W111	Validated Y2H	25416956
Intra	CAMK2B	Q13554	SPRYD7	Homo sapiens	Q5W111	Y2H Array	25416956
Intra	CAMK2B	Q13554	FAM171A2	Homo sapiens	Q8N0U1	Y2H Array	25416956
Intra	CAMK2B	Q13554	FAM171A2	Homo sapiens	Q8N0U1	Validated Y2H	25416956
Intra	CAMK2B	Q13554	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	25416956
Intra	CAMK2B	Q13554	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	AP5B1	Homo sapiens	Q2VPB7	Validated Y2H	25416956
Intra	CAMK2B	Q13554	CAMK2B	Homo sapiens	Q13554	Solution Sedimentation	20668654
Intra	CAMK2B	Q13554	AP5B1	Homo sapiens	Q2VPB7	Y2H Array	25416956
Intra	CAMK2B	Q13554	CAMK2A	Homo sapiens	Q9UQM7	Anti Tag CoIP	29426014
Intra	CAMK2B	Q13554	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	CAMK2B	Q13554	CAMK2D	Homo sapiens	Q13557	Pull Down	32707033
Intra	CAMK2B	Q13554	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	29426014
Intra	CAMK2B	Q13554	CAMK2D	Homo sapiens	Q13557	Solution Sedimentation	20668654
Intra	CAMK2B	Q13554	RPL11	Homo sapiens	P62913	Validated Y2H	25416956
Intra	CAMK2B	Q13554	RPL11	Homo sapiens	P62913	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	POP5	Homo sapiens	Q969H6	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	MED18	Homo sapiens	Q9BUE0	Y2H Array	25416956
Intra	CAMK2B	Q13554	MED18	Homo sapiens	Q9BUE0	Validated Y2H	25416956
Intra	CAMK2B	Q13554	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	CAMK2B	Q13554	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	25416956
Intra	CAMK2B	Q13554	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	CAMK2B	Q13554	RBFOX2	Homo sapiens	O43251	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	RBFOX2	Homo sapiens	O43251	Validated Y2H	25416956
Intra	CAMK2B	Q13554	RAP2B	Homo sapiens	P61225	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	RAP2B	Homo sapiens	P61225	Validated Y2H	25416956
Intra	CAMK2B	Q13554	MAD2L2	Homo sapiens	Q9UI95	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	SEMA4G	Homo sapiens	Q9NTN9-3	Y2H Prey Pooling	25416956
Intra	CAMK2B	Q13554	ACOT7	Homo sapiens	O00154	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76762	CaMKII beta/CAMK2B Protein, Human (Active, sf9, His-GST)	Q13554-3 (M1-Q503)	≥ 80%, as determined by reducing SDS-PAGE.

CAMK2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810546	Phospho-CaMKII (Thr286) Antibody (YA9815)	WB	Human, Mouse, Rat
HY-P82599	CaMKII beta Antibody (YA2344)	WB	Mouse
HY-P82599A	CaMKII beta Antibody (YA2344)(PBS only)	WB	Mouse
HY-P84930	CaMKII Antibody (YA4627)	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat, Monkey, Pig
HY-P86066	Phospho-CaMKIIβ/γ/δ Antibody (YA5758)	IHC-P, ICC/IF	Human, Rat, Mouse
HY-P86423	CaMKII beta Antibody (YA6115)	WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 54	Mental Retardation, Autosomal Dominant 54 MRD54 Autosomal Dominant Intellectual Developmental Disorder 54 Autosomal Dominant Mental Retardation 54
Autosomal Dominant Non-Syndromic Intellectual Disability
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Anterior Segment Dysgenesis 5	Anterior Segment Dysgenesis 5, Multiple Subtypes ASGD5 Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01857	CAMK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20531	Camk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27040	Camk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAMK2B	VGNC	VGNC:26722
Rattus norvegicus	CAMK2B	RGD	RGD:2262
Macaca mulatta	CAMK2B	VGNC	VGNC:70524
Mus musculus	CAMK2B	MGD	MGI:88257
Felis catus	CAMK2B	VGNC	VGNC:60332
Others	CAMK2B	NCBI